Cerebral metastases in non-seminomatous germ cell tumour patients undergoing primary high-dose chemotherapy.
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Cerebral metastases in non-seminomatous germ cell tumour patients undergoing primary high-dose chemotherapy. / Oechsle, Karin; Kollmannsberger, C; Honecker, Friedemann; Boehlke, I; Bokemeyer, Carsten.
in: EUR J CANCER, Jahrgang 44, Nr. 12, 12, 2008, S. 1663-1669.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Cerebral metastases in non-seminomatous germ cell tumour patients undergoing primary high-dose chemotherapy.
AU - Oechsle, Karin
AU - Kollmannsberger, C
AU - Honecker, Friedemann
AU - Boehlke, I
AU - Bokemeyer, Carsten
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Retrospective analysis of characteristics and outcome of germ cell tumour (GCT) patients with cerebral metastases (CM) undergoing high-dose chemotherapy (HD-CTX) or relapsing with CM. PATIENTS AND METHODS: Patients initially presenting with CM (N=50 pts) or at first relapse (n=19 pts) after primary HD-CTX (434 pts) were analysed. RESULTS: Patients with primary CM (N=50) had elevated ss-human chorion gonadotropin (ss-HCG) in 88% and lung metastases in 90%. Eighty six percent responded to HD-CTX and 40% underwent CNS radiotherapy. Forty four percent achieved long-term survival after primary and 16% after salvage treatment (60% in total). All patients relapsing with CM (n=19) presented initially with ss-HCG-elevation and pulmonary metastases. Treatment consisted of CTX in 78%, irradiation in 90% and surgery in 63%. Twenty six percent achieved long-term survival. CONCLUSION: An interdisciplinary approach of HD-CTX, radiotherapy and surgery leads to long-term survival in 60% of patients with CM at initial diagnosis and 26% relapsing with CM.
AB - BACKGROUND: Retrospective analysis of characteristics and outcome of germ cell tumour (GCT) patients with cerebral metastases (CM) undergoing high-dose chemotherapy (HD-CTX) or relapsing with CM. PATIENTS AND METHODS: Patients initially presenting with CM (N=50 pts) or at first relapse (n=19 pts) after primary HD-CTX (434 pts) were analysed. RESULTS: Patients with primary CM (N=50) had elevated ss-human chorion gonadotropin (ss-HCG) in 88% and lung metastases in 90%. Eighty six percent responded to HD-CTX and 40% underwent CNS radiotherapy. Forty four percent achieved long-term survival after primary and 16% after salvage treatment (60% in total). All patients relapsing with CM (n=19) presented initially with ss-HCG-elevation and pulmonary metastases. Treatment consisted of CTX in 78%, irradiation in 90% and surgery in 63%. Twenty six percent achieved long-term survival. CONCLUSION: An interdisciplinary approach of HD-CTX, radiotherapy and surgery leads to long-term survival in 60% of patients with CM at initial diagnosis and 26% relapsing with CM.
M3 - SCORING: Zeitschriftenaufsatz
VL - 44
SP - 1663
EP - 1669
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 12
M1 - 12
ER -
