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Cerebral blood flow predicts lesion growth in acute stroke patients.

Standard

Cerebral blood flow predicts lesion growth in acute stroke patients. / Fiehler, Jens; von Bezold, Michael; Kucinski, Thomas; Knab, René; Eckert, Bernd; Wittkugel, Oliver; Zeumer, Hermann; Röther, Joachim.

in: STROKE, Jahrgang 33, Nr. 10, 10, 2002, S. 2421-2425.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fiehler, J, von Bezold, M, Kucinski, T, Knab, R, Eckert, B, Wittkugel, O, Zeumer, H & Röther, J 2002, 'Cerebral blood flow predicts lesion growth in acute stroke patients.', STROKE, Jg. 33, Nr. 10, 10, S. 2421-2425. <http://www.ncbi.nlm.nih.gov/pubmed/12364732?dopt=Citation>

APA

Fiehler, J., von Bezold, M., Kucinski, T., Knab, R., Eckert, B., Wittkugel, O., Zeumer, H., & Röther, J. (2002). Cerebral blood flow predicts lesion growth in acute stroke patients. STROKE, 33(10), 2421-2425. [10]. http://www.ncbi.nlm.nih.gov/pubmed/12364732?dopt=Citation

Vancouver

Fiehler J, von Bezold M, Kucinski T, Knab R, Eckert B, Wittkugel O et al. Cerebral blood flow predicts lesion growth in acute stroke patients. STROKE. 2002;33(10):2421-2425. 10.

Bibtex

@article{6690a9fd15a848e2bce559453f4df0bf,
title = "Cerebral blood flow predicts lesion growth in acute stroke patients.",
abstract = "BACKGROUND AND PURPOSE: We sought to study the role of MRI-derived cerebral blood flow (CBF) measurements for the prediction of lesion development in acute stroke patients. METHODS: Thirty-two patients were treated with tissue plasminogen activator. Diffusion-weighted (DWI) and perfusion-weighted MRI, T2-weighted imaging, and MR angiography were performed before treatment (2.8+/-0.9 hours after symptom onset) and on follow-up (days 1 and 7). CBF thresholds (12 and 22 mL/100 g per minute) were applied to bolus tracking MRI maps to determine predictive cutoff levels. RESULTS: In 21 patients (group A), the terminal lesion volume (T2-weighted imaging) was larger than the initial DWI lesion volume (89+/-93 versus 21+/-38 mL). In 11 patients (group B), the terminal lesion volume was smaller than the initial DWI lesion volume (7+/-27 versus 15+/-29 mL). The initial DWI lesion volume did not differ between both groups. The presence of a tissue volume > or =50 mL with a CBF value or =50 mL with a CBF value <or =12 mL/100 g per minute predicts further lesion growth in hyperacute stroke patients. MRI-derived CBF values, with all their present limitations, are valuable in early estimation of prognosis of stroke patients.",
author = "Jens Fiehler and {von Bezold}, Michael and Thomas Kucinski and Ren{\'e} Knab and Bernd Eckert and Oliver Wittkugel and Hermann Zeumer and Joachim R{\"o}ther",
year = "2002",
language = "Deutsch",
volume = "33",
pages = "2421--2425",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - Cerebral blood flow predicts lesion growth in acute stroke patients.

AU - Fiehler, Jens

AU - von Bezold, Michael

AU - Kucinski, Thomas

AU - Knab, René

AU - Eckert, Bernd

AU - Wittkugel, Oliver

AU - Zeumer, Hermann

AU - Röther, Joachim

PY - 2002

Y1 - 2002

N2 - BACKGROUND AND PURPOSE: We sought to study the role of MRI-derived cerebral blood flow (CBF) measurements for the prediction of lesion development in acute stroke patients. METHODS: Thirty-two patients were treated with tissue plasminogen activator. Diffusion-weighted (DWI) and perfusion-weighted MRI, T2-weighted imaging, and MR angiography were performed before treatment (2.8+/-0.9 hours after symptom onset) and on follow-up (days 1 and 7). CBF thresholds (12 and 22 mL/100 g per minute) were applied to bolus tracking MRI maps to determine predictive cutoff levels. RESULTS: In 21 patients (group A), the terminal lesion volume (T2-weighted imaging) was larger than the initial DWI lesion volume (89+/-93 versus 21+/-38 mL). In 11 patients (group B), the terminal lesion volume was smaller than the initial DWI lesion volume (7+/-27 versus 15+/-29 mL). The initial DWI lesion volume did not differ between both groups. The presence of a tissue volume > or =50 mL with a CBF value or =50 mL with a CBF value <or =12 mL/100 g per minute predicts further lesion growth in hyperacute stroke patients. MRI-derived CBF values, with all their present limitations, are valuable in early estimation of prognosis of stroke patients.

AB - BACKGROUND AND PURPOSE: We sought to study the role of MRI-derived cerebral blood flow (CBF) measurements for the prediction of lesion development in acute stroke patients. METHODS: Thirty-two patients were treated with tissue plasminogen activator. Diffusion-weighted (DWI) and perfusion-weighted MRI, T2-weighted imaging, and MR angiography were performed before treatment (2.8+/-0.9 hours after symptom onset) and on follow-up (days 1 and 7). CBF thresholds (12 and 22 mL/100 g per minute) were applied to bolus tracking MRI maps to determine predictive cutoff levels. RESULTS: In 21 patients (group A), the terminal lesion volume (T2-weighted imaging) was larger than the initial DWI lesion volume (89+/-93 versus 21+/-38 mL). In 11 patients (group B), the terminal lesion volume was smaller than the initial DWI lesion volume (7+/-27 versus 15+/-29 mL). The initial DWI lesion volume did not differ between both groups. The presence of a tissue volume > or =50 mL with a CBF value or =50 mL with a CBF value <or =12 mL/100 g per minute predicts further lesion growth in hyperacute stroke patients. MRI-derived CBF values, with all their present limitations, are valuable in early estimation of prognosis of stroke patients.

M3 - SCORING: Zeitschriftenaufsatz

VL - 33

SP - 2421

EP - 2425

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 10

M1 - 10

ER -