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Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients

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Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients. / Kriegsmann, Katharina; Baertsch, Marc-Andrea; Awwad, Mohamed H S; Merz, Maximilian; Hose, Dirk; Seckinger, Anja; Jauch, Anna; Becker, Natalia; Benner, Axel; Raab, Marc S; Hillengass, Jens; Bertsch, Uta; Dürig, Jan; Salwender, Hans Jürgen; Hänel, Mathias; Fenk, Roland; Munder, Markus; Weisel, Katja; Müller-Tidow, Carsten; Goldschmidt, Hartmut; Hundemer, Michael.

in: BLOOD CANCER J, Jahrgang 9, Nr. 2, 29.01.2019, S. 13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kriegsmann, K, Baertsch, M-A, Awwad, MHS, Merz, M, Hose, D, Seckinger, A, Jauch, A, Becker, N, Benner, A, Raab, MS, Hillengass, J, Bertsch, U, Dürig, J, Salwender, HJ, Hänel, M, Fenk, R, Munder, M, Weisel, K, Müller-Tidow, C, Goldschmidt, H & Hundemer, M 2019, 'Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients', BLOOD CANCER J, Jg. 9, Nr. 2, S. 13. https://doi.org/10.1038/s41408-019-0174-z

APA

Kriegsmann, K., Baertsch, M-A., Awwad, M. H. S., Merz, M., Hose, D., Seckinger, A., Jauch, A., Becker, N., Benner, A., Raab, M. S., Hillengass, J., Bertsch, U., Dürig, J., Salwender, H. J., Hänel, M., Fenk, R., Munder, M., Weisel, K., Müller-Tidow, C., ... Hundemer, M. (2019). Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients. BLOOD CANCER J, 9(2), 13. https://doi.org/10.1038/s41408-019-0174-z

Vancouver

Kriegsmann K, Baertsch M-A, Awwad MHS, Merz M, Hose D, Seckinger A et al. Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients. BLOOD CANCER J. 2019 Jan 29;9(2):13. https://doi.org/10.1038/s41408-019-0174-z

Bibtex

@article{080409d4dfa64f4da935554735e0226e,
title = "Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients",
abstract = "Immunomodulatory drugs (IMIDs) are very effective in the treatment of multiple myeloma (MM). The description of their cereblon-mediated mechanism of action was a hallmark in MM research. Although the importance of IMID-induced degradation of cereblon-binding proteins is well described in vitro, the prognostic value of their expression levels in MM cells is less clear. Based on recently published data showing somewhat conflicting RNA levels, we analyzed the association between the levels of the Ikaros family zinc finger protein 1 (IKZF1), IKZF3, and karyopherin subunit alpha 2 (KPNA2) proteins measured by flow cytometry and prognostic parameters in 214 newly diagnosed MM patients who were randomized in the GMMG HD6 trial. No statistically significant associations between the expression levels and age, gender, light chain type, International Staging System (ISS) stage or cytogenetic high- and normal risk groups could be identified. Hyperdiploid MM cells expressed significantly higher levels of IKZF1, IKZF3 and KPNA2 than nonhyperdiploid cells. In contrast, translocation t(11;14) was associated with significantly lower expression levels. In conclusion, the observed overexpression of cereblon-binding proteins in MM cells with gain of chromosomes 5, 9, 11, 15, and 19 is consistent with the previously proposed positive regulation of MYC by IKZF1 and IKZF3, as well as MYC activation in hyperdiploid MM cells.",
keywords = "Journal Article",
author = "Katharina Kriegsmann and Marc-Andrea Baertsch and Awwad, {Mohamed H S} and Maximilian Merz and Dirk Hose and Anja Seckinger and Anna Jauch and Natalia Becker and Axel Benner and Raab, {Marc S} and Jens Hillengass and Uta Bertsch and Jan D{\"u}rig and Salwender, {Hans J{\"u}rgen} and Mathias H{\"a}nel and Roland Fenk and Markus Munder and Katja Weisel and Carsten M{\"u}ller-Tidow and Hartmut Goldschmidt and Michael Hundemer",
year = "2019",
month = jan,
day = "29",
doi = "10.1038/s41408-019-0174-z",
language = "English",
volume = "9",
pages = "13",
journal = "BLOOD CANCER J",
issn = "2044-5385",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients

AU - Kriegsmann, Katharina

AU - Baertsch, Marc-Andrea

AU - Awwad, Mohamed H S

AU - Merz, Maximilian

AU - Hose, Dirk

AU - Seckinger, Anja

AU - Jauch, Anna

AU - Becker, Natalia

AU - Benner, Axel

AU - Raab, Marc S

AU - Hillengass, Jens

AU - Bertsch, Uta

AU - Dürig, Jan

AU - Salwender, Hans Jürgen

AU - Hänel, Mathias

AU - Fenk, Roland

AU - Munder, Markus

AU - Weisel, Katja

AU - Müller-Tidow, Carsten

AU - Goldschmidt, Hartmut

AU - Hundemer, Michael

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Immunomodulatory drugs (IMIDs) are very effective in the treatment of multiple myeloma (MM). The description of their cereblon-mediated mechanism of action was a hallmark in MM research. Although the importance of IMID-induced degradation of cereblon-binding proteins is well described in vitro, the prognostic value of their expression levels in MM cells is less clear. Based on recently published data showing somewhat conflicting RNA levels, we analyzed the association between the levels of the Ikaros family zinc finger protein 1 (IKZF1), IKZF3, and karyopherin subunit alpha 2 (KPNA2) proteins measured by flow cytometry and prognostic parameters in 214 newly diagnosed MM patients who were randomized in the GMMG HD6 trial. No statistically significant associations between the expression levels and age, gender, light chain type, International Staging System (ISS) stage or cytogenetic high- and normal risk groups could be identified. Hyperdiploid MM cells expressed significantly higher levels of IKZF1, IKZF3 and KPNA2 than nonhyperdiploid cells. In contrast, translocation t(11;14) was associated with significantly lower expression levels. In conclusion, the observed overexpression of cereblon-binding proteins in MM cells with gain of chromosomes 5, 9, 11, 15, and 19 is consistent with the previously proposed positive regulation of MYC by IKZF1 and IKZF3, as well as MYC activation in hyperdiploid MM cells.

AB - Immunomodulatory drugs (IMIDs) are very effective in the treatment of multiple myeloma (MM). The description of their cereblon-mediated mechanism of action was a hallmark in MM research. Although the importance of IMID-induced degradation of cereblon-binding proteins is well described in vitro, the prognostic value of their expression levels in MM cells is less clear. Based on recently published data showing somewhat conflicting RNA levels, we analyzed the association between the levels of the Ikaros family zinc finger protein 1 (IKZF1), IKZF3, and karyopherin subunit alpha 2 (KPNA2) proteins measured by flow cytometry and prognostic parameters in 214 newly diagnosed MM patients who were randomized in the GMMG HD6 trial. No statistically significant associations between the expression levels and age, gender, light chain type, International Staging System (ISS) stage or cytogenetic high- and normal risk groups could be identified. Hyperdiploid MM cells expressed significantly higher levels of IKZF1, IKZF3 and KPNA2 than nonhyperdiploid cells. In contrast, translocation t(11;14) was associated with significantly lower expression levels. In conclusion, the observed overexpression of cereblon-binding proteins in MM cells with gain of chromosomes 5, 9, 11, 15, and 19 is consistent with the previously proposed positive regulation of MYC by IKZF1 and IKZF3, as well as MYC activation in hyperdiploid MM cells.

KW - Journal Article

U2 - 10.1038/s41408-019-0174-z

DO - 10.1038/s41408-019-0174-z

M3 - SCORING: Journal article

C2 - 30696815

VL - 9

SP - 13

JO - BLOOD CANCER J

JF - BLOOD CANCER J

SN - 2044-5385

IS - 2

ER -