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Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT)

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Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT). / Schetelig, Johannes; de Wreede, Liesbeth C; Andersen, Niels S; Moreno, Carol; van Gelder, Michel; Vitek, Antonin; Karas, Michal; Michallet, Mauricette; Machaczka, Maciej; Gramatzki, Martin; Beelen, Dietrich; Finke, Jürgen; Delgado, Julio; Volin, Liisa; Passweg, Jakob; Dreger, Peter; Schaap, Nicolaas; Wagner, Eva; Henseler, Anja; van Biezen, Anja; Bornhäuser, Martin; Iacobelli, Simona; Putter, Hein; Schönland, Stefan O; Kröger, Nicolaus; CLL subcommittee, Chronic Malignancies Working Party.

in: BRIT J HAEMATOL, Jahrgang 178, Nr. 4, 08.2017, S. 521-533.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schetelig, J, de Wreede, LC, Andersen, NS, Moreno, C, van Gelder, M, Vitek, A, Karas, M, Michallet, M, Machaczka, M, Gramatzki, M, Beelen, D, Finke, J, Delgado, J, Volin, L, Passweg, J, Dreger, P, Schaap, N, Wagner, E, Henseler, A, van Biezen, A, Bornhäuser, M, Iacobelli, S, Putter, H, Schönland, SO, Kröger, N & CLL subcommittee, Chronic Malignancies Working Party 2017, 'Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT)', BRIT J HAEMATOL, Jg. 178, Nr. 4, S. 521-533. https://doi.org/10.1111/bjh.14791

APA

Schetelig, J., de Wreede, L. C., Andersen, N. S., Moreno, C., van Gelder, M., Vitek, A., Karas, M., Michallet, M., Machaczka, M., Gramatzki, M., Beelen, D., Finke, J., Delgado, J., Volin, L., Passweg, J., Dreger, P., Schaap, N., Wagner, E., Henseler, A., ... CLL subcommittee, Chronic Malignancies Working Party (2017). Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT). BRIT J HAEMATOL, 178(4), 521-533. https://doi.org/10.1111/bjh.14791

Vancouver

Schetelig J, de Wreede LC, Andersen NS, Moreno C, van Gelder M, Vitek A et al. Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT). BRIT J HAEMATOL. 2017 Aug;178(4):521-533. https://doi.org/10.1111/bjh.14791

Bibtex

@article{6d043b15e0da46ac9faa5b319a75db5f,
title = "Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT)",
abstract = "The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown. We therefore analysed the impact of procedure- and centre-related factors on 5-year event-free survival (EFS) in a large retrospective study. Data of 684 CLL patients who received a first alloHCT between 2000 and 2011 were analysed by multivariable Cox proportional hazards models with a frailty component to investigate unexplained centre heterogeneity. Five-year EFS of the whole cohort was 37% (95% confidence interval [CI], 34-42%). Larger numbers of CLL alloHCTs (hazard ratio [HR] 0·96, P = 0·002), certification of quality management (HR 0·7, P = 0·045) and a higher gross national income per capita (HR 0·4, P = 0·04) improved EFS. In vivo T-cell depletion (TCD) with alemtuzumab compared to no TCD (HR 1·5, P = 0·03), and a female donor compared to a male donor for a male patient (HR 1·4, P = 0·02) had a negative impact on EFS, but not non-myeloablative versus more intensive conditioning. After correcting for patient-, procedure- and centre-characteristics, significant variation in centre outcomes persisted. In conclusion, further research on the impact of centre and procedural characteristics is warranted. Non-myeloablative conditioning appears to be the preferable approach for patients with CLL.",
keywords = "Journal Article",
author = "Johannes Schetelig and {de Wreede}, {Liesbeth C} and Andersen, {Niels S} and Carol Moreno and {van Gelder}, Michel and Antonin Vitek and Michal Karas and Mauricette Michallet and Maciej Machaczka and Martin Gramatzki and Dietrich Beelen and J{\"u}rgen Finke and Julio Delgado and Liisa Volin and Jakob Passweg and Peter Dreger and Nicolaas Schaap and Eva Wagner and Anja Henseler and {van Biezen}, Anja and Martin Bornh{\"a}user and Simona Iacobelli and Hein Putter and Sch{\"o}nland, {Stefan O} and Nicolaus Kr{\"o}ger and {CLL subcommittee, Chronic Malignancies Working Party}",
note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",
year = "2017",
month = aug,
doi = "10.1111/bjh.14791",
language = "English",
volume = "178",
pages = "521--533",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT)

AU - Schetelig, Johannes

AU - de Wreede, Liesbeth C

AU - Andersen, Niels S

AU - Moreno, Carol

AU - van Gelder, Michel

AU - Vitek, Antonin

AU - Karas, Michal

AU - Michallet, Mauricette

AU - Machaczka, Maciej

AU - Gramatzki, Martin

AU - Beelen, Dietrich

AU - Finke, Jürgen

AU - Delgado, Julio

AU - Volin, Liisa

AU - Passweg, Jakob

AU - Dreger, Peter

AU - Schaap, Nicolaas

AU - Wagner, Eva

AU - Henseler, Anja

AU - van Biezen, Anja

AU - Bornhäuser, Martin

AU - Iacobelli, Simona

AU - Putter, Hein

AU - Schönland, Stefan O

AU - Kröger, Nicolaus

AU - CLL subcommittee, Chronic Malignancies Working Party

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2017/8

Y1 - 2017/8

N2 - The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown. We therefore analysed the impact of procedure- and centre-related factors on 5-year event-free survival (EFS) in a large retrospective study. Data of 684 CLL patients who received a first alloHCT between 2000 and 2011 were analysed by multivariable Cox proportional hazards models with a frailty component to investigate unexplained centre heterogeneity. Five-year EFS of the whole cohort was 37% (95% confidence interval [CI], 34-42%). Larger numbers of CLL alloHCTs (hazard ratio [HR] 0·96, P = 0·002), certification of quality management (HR 0·7, P = 0·045) and a higher gross national income per capita (HR 0·4, P = 0·04) improved EFS. In vivo T-cell depletion (TCD) with alemtuzumab compared to no TCD (HR 1·5, P = 0·03), and a female donor compared to a male donor for a male patient (HR 1·4, P = 0·02) had a negative impact on EFS, but not non-myeloablative versus more intensive conditioning. After correcting for patient-, procedure- and centre-characteristics, significant variation in centre outcomes persisted. In conclusion, further research on the impact of centre and procedural characteristics is warranted. Non-myeloablative conditioning appears to be the preferable approach for patients with CLL.

AB - The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown. We therefore analysed the impact of procedure- and centre-related factors on 5-year event-free survival (EFS) in a large retrospective study. Data of 684 CLL patients who received a first alloHCT between 2000 and 2011 were analysed by multivariable Cox proportional hazards models with a frailty component to investigate unexplained centre heterogeneity. Five-year EFS of the whole cohort was 37% (95% confidence interval [CI], 34-42%). Larger numbers of CLL alloHCTs (hazard ratio [HR] 0·96, P = 0·002), certification of quality management (HR 0·7, P = 0·045) and a higher gross national income per capita (HR 0·4, P = 0·04) improved EFS. In vivo T-cell depletion (TCD) with alemtuzumab compared to no TCD (HR 1·5, P = 0·03), and a female donor compared to a male donor for a male patient (HR 1·4, P = 0·02) had a negative impact on EFS, but not non-myeloablative versus more intensive conditioning. After correcting for patient-, procedure- and centre-characteristics, significant variation in centre outcomes persisted. In conclusion, further research on the impact of centre and procedural characteristics is warranted. Non-myeloablative conditioning appears to be the preferable approach for patients with CLL.

KW - Journal Article

U2 - 10.1111/bjh.14791

DO - 10.1111/bjh.14791

M3 - SCORING: Journal article

C2 - 28589551

VL - 178

SP - 521

EP - 533

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 4

ER -