Central insulin modulates food valuation via mesolimbic pathways

Lena J Tiedemann; Sebastian M Schmid; Judith Hettel; Katrin Giesen; Paul Francke; Christian Büchel; Stefanie Brassen

doi:10.1038/ncomms16052

Central insulin modulates food valuation via mesolimbic pathways

Standard

Central insulin modulates food valuation via mesolimbic pathways. / Tiedemann, Lena J; Schmid, Sebastian M; Hettel, Judith; Giesen, Katrin; Francke, Paul ; Büchel, Christian ; Brassen, Stefanie.

in: NAT COMMUN, Jahrgang 8, 18.07.2017, S. 16052.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tiedemann, LJ, Schmid, SM, Hettel, J, Giesen, K, Francke, P , Büchel, C & Brassen, S 2017, 'Central insulin modulates food valuation via mesolimbic pathways', NAT COMMUN, Jg. 8, S. 16052. https://doi.org/10.1038/ncomms16052

APA

Tiedemann, L. J., Schmid, S. M., Hettel, J., Giesen, K., Francke, P., Büchel, C., & Brassen, S. (2017). Central insulin modulates food valuation via mesolimbic pathways. NAT COMMUN, 8, 16052. https://doi.org/10.1038/ncomms16052

Vancouver

Tiedemann LJ, Schmid SM, Hettel J, Giesen K, Francke P , Büchel C et al. Central insulin modulates food valuation via mesolimbic pathways. NAT COMMUN. 2017 Jul 18;8:16052. https://doi.org/10.1038/ncomms16052

Bibtex

@article{be2046a8ba66400baf4537d792acc939,

title = "Central insulin modulates food valuation via mesolimbic pathways",

abstract = "Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures and attractiveness of non-food items (control) after receiving INI or placebo. We report that INI reduces ratings of food palatability and value signals in mesolimbic regions in individuals with normal insulin sensitivity. Connectivity analyses reveal insulinergic inhibition of forward projections from the ventral tegmentum to the nucleus accumbens. Importantly, the strength of this modulation predicts decrease of palatability ratings, directly linking neural findings to behaviour. In insulin-resistant participants however, we observe reduced food values and aberrant central insulin action. These data demonstrate how central insulin modulates the cross-talk between homeostatic and non-homeostatic feeding systems, suggesting that dysfunctions of these neural interactions may promote metabolic disorders.",

keywords = "Journal Article",

author = "Tiedemann, {Lena J} and Schmid, {Sebastian M} and Judith Hettel and Katrin Giesen and Paul Francke and Christian B{\"u}chel and Stefanie Brassen",

year = "2017",

month = jul,

day = "18",

doi = "10.1038/ncomms16052",

language = "English",

volume = "8",

pages = "16052",

journal = "NAT COMMUN",

issn = "2041-1723",

publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Central insulin modulates food valuation via mesolimbic pathways

AU - Tiedemann, Lena J

AU - Schmid, Sebastian M

AU - Hettel, Judith

AU - Giesen, Katrin

AU - Francke, Paul

AU - Büchel, Christian

AU - Brassen, Stefanie

PY - 2017/7/18

Y1 - 2017/7/18

N2 - Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures and attractiveness of non-food items (control) after receiving INI or placebo. We report that INI reduces ratings of food palatability and value signals in mesolimbic regions in individuals with normal insulin sensitivity. Connectivity analyses reveal insulinergic inhibition of forward projections from the ventral tegmentum to the nucleus accumbens. Importantly, the strength of this modulation predicts decrease of palatability ratings, directly linking neural findings to behaviour. In insulin-resistant participants however, we observe reduced food values and aberrant central insulin action. These data demonstrate how central insulin modulates the cross-talk between homeostatic and non-homeostatic feeding systems, suggesting that dysfunctions of these neural interactions may promote metabolic disorders.

AB - Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures and attractiveness of non-food items (control) after receiving INI or placebo. We report that INI reduces ratings of food palatability and value signals in mesolimbic regions in individuals with normal insulin sensitivity. Connectivity analyses reveal insulinergic inhibition of forward projections from the ventral tegmentum to the nucleus accumbens. Importantly, the strength of this modulation predicts decrease of palatability ratings, directly linking neural findings to behaviour. In insulin-resistant participants however, we observe reduced food values and aberrant central insulin action. These data demonstrate how central insulin modulates the cross-talk between homeostatic and non-homeostatic feeding systems, suggesting that dysfunctions of these neural interactions may promote metabolic disorders.

KW - Journal Article

U2 - 10.1038/ncomms16052

DO - 10.1038/ncomms16052

M3 - SCORING: Journal article

C2 - 28719580

VL - 8

SP - 16052

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -