Cellulose Nanofiber-Reinforced Chitosan Hydrogel Composites for Intervertebral Disc Tissue Repair
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Cellulose Nanofiber-Reinforced Chitosan Hydrogel Composites for Intervertebral Disc Tissue Repair. / Doench, Ingo; Ahn Tran, Tuan; David, Laurent; Montembault, Alexandra; Viguier, Eric; Gorzelanny, Christian; Sudre, Guillaume; Cachon, Thibaut; Louback-Mohamed, Malika; Horbelt, Niels; Peniche-Covas, Carlos; Osorio-Madrazo, Anayancy.
in: BIOMIMETICS-BASEL, Jahrgang 4, Nr. 1, 20.02.2019.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cellulose Nanofiber-Reinforced Chitosan Hydrogel Composites for Intervertebral Disc Tissue Repair
AU - Doench, Ingo
AU - Ahn Tran, Tuan
AU - David, Laurent
AU - Montembault, Alexandra
AU - Viguier, Eric
AU - Gorzelanny, Christian
AU - Sudre, Guillaume
AU - Cachon, Thibaut
AU - Louback-Mohamed, Malika
AU - Horbelt, Niels
AU - Peniche-Covas, Carlos
AU - Osorio-Madrazo, Anayancy
PY - 2019/2/20
Y1 - 2019/2/20
N2 - The development of non-cellularized composites of chitosan (CHI) hydrogels, filled with cellulose nanofibers (CNFs) of the type nanofibrillated cellulose, was proposed for the repair and regeneration of the intervertebral disc (IVD) annulus fibrosus (AF) tissue. With the achievement of CNF-filled CHI hydrogels, biomaterial-based implants were designed to restore damaged/degenerated discs. The structural, mechanical and biological properties of the developed hydrogel composites were investigated. The neutralization of weakly acidic aqueous CNF/CHI viscous suspensions in NaOH yielded composites of physical hydrogels in which the cellulose nanofibers reinforced the CHI matrix, as investigated by means of microtensile testing under controlled humidity. We assessed the suitability of the achieved biomaterials for intervertebral disc tissue engineering in ex vivo experiments using spine pig models. Cellulose nanofiber-filled chitosan hydrogels can be used as implants in AF tissue defects to restore IVD biomechanics and constitute contention patches against disc nucleus protrusion while serving as support for IVD regeneration.
AB - The development of non-cellularized composites of chitosan (CHI) hydrogels, filled with cellulose nanofibers (CNFs) of the type nanofibrillated cellulose, was proposed for the repair and regeneration of the intervertebral disc (IVD) annulus fibrosus (AF) tissue. With the achievement of CNF-filled CHI hydrogels, biomaterial-based implants were designed to restore damaged/degenerated discs. The structural, mechanical and biological properties of the developed hydrogel composites were investigated. The neutralization of weakly acidic aqueous CNF/CHI viscous suspensions in NaOH yielded composites of physical hydrogels in which the cellulose nanofibers reinforced the CHI matrix, as investigated by means of microtensile testing under controlled humidity. We assessed the suitability of the achieved biomaterials for intervertebral disc tissue engineering in ex vivo experiments using spine pig models. Cellulose nanofiber-filled chitosan hydrogels can be used as implants in AF tissue defects to restore IVD biomechanics and constitute contention patches against disc nucleus protrusion while serving as support for IVD regeneration.
U2 - 10.3390/biomimetics4010019
DO - 10.3390/biomimetics4010019
M3 - SCORING: Journal article
C2 - 31105204
VL - 4
JO - BIOMIMETICS-BASEL
JF - BIOMIMETICS-BASEL
SN - 2313-7673
IS - 1
ER -
