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Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Standard

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. / Thiele, Swantje; Stanelle-Bertram, Stephanie; Beck, Sebastian; Kouassi, Nancy Mounogou; Zickler, Martin; Müller, Martin; Tuku, Berfin; Resa-Infante, Patricia; van Riel, Debby; Alawi, Malik; Günther, Thomas; Rother, Franziska; Hügel, Stefanie; Reimering, Susanne; McHardy, Alice; Grundhoff, Adam; Brune, Wolfram; Osterhaus, Albert; Bader, Michael; Hartmann, Enno; Gabriel, Gülsah.

in: CELL REP, Jahrgang 31, Nr. 3, 107549, 21.04.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Thiele, S, Stanelle-Bertram, S, Beck, S, Kouassi, NM, Zickler, M, Müller, M, Tuku, B, Resa-Infante, P, van Riel, D, Alawi, M, Günther, T, Rother, F, Hügel, S, Reimering, S, McHardy, A, Grundhoff, A, Brune, W, Osterhaus, A, Bader, M, Hartmann, E & Gabriel, G 2020, 'Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection', CELL REP, Jg. 31, Nr. 3, 107549. https://doi.org/10.1016/j.celrep.2020.107549

APA

Thiele, S., Stanelle-Bertram, S., Beck, S., Kouassi, N. M., Zickler, M., Müller, M., Tuku, B., Resa-Infante, P., van Riel, D., Alawi, M., Günther, T., Rother, F., Hügel, S., Reimering, S., McHardy, A., Grundhoff, A., Brune, W., Osterhaus, A., Bader, M., ... Gabriel, G. (2020). Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. CELL REP, 31(3), [107549]. https://doi.org/10.1016/j.celrep.2020.107549

Vancouver

Thiele S, Stanelle-Bertram S, Beck S, Kouassi NM, Zickler M, Müller M et al. Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. CELL REP. 2020 Apr 21;31(3). 107549. https://doi.org/10.1016/j.celrep.2020.107549

Bibtex

@article{b1e972404a504445b096c1b7a4f54bbf,
title = "Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection",
abstract = "Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor in the mammalian respiratory tract. Importin-α3 promoter activity is regulated by TNF-α-induced NF-κB in a concentration-dependent manner. High-level TNF-α-inducing highly pathogenic avian influenza A viruses (HPAIVs) isolated from fatal human cases harboring human-type polymerase signatures (PB2 627K, 701N) significantly downregulate importin-α3 mRNA expression in primary lung cells. Importin-α3 depletion is restored upon back-mutating the HPAIV polymerase into an avian-type signature (PB2 627E, 701D) that can no longer induce high TNF-α levels. Importin-α3-deficient mice show reduced NF-κB-activated antiviral gene expression and increased influenza lethality. Thus, importin-α3 plays a key role in antiviral immunity against influenza. Lifting the bottleneck in importin-α3 availability in the lung might provide a new strategy to combat respiratory virus infections.",
author = "Swantje Thiele and Stephanie Stanelle-Bertram and Sebastian Beck and Kouassi, {Nancy Mounogou} and Martin Zickler and Martin M{\"u}ller and Berfin Tuku and Patricia Resa-Infante and {van Riel}, Debby and Malik Alawi and Thomas G{\"u}nther and Franziska Rother and Stefanie H{\"u}gel and Susanne Reimering and Alice McHardy and Adam Grundhoff and Wolfram Brune and Albert Osterhaus and Michael Bader and Enno Hartmann and G{\"u}lsah Gabriel",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = apr,
day = "21",
doi = "10.1016/j.celrep.2020.107549",
language = "English",
volume = "31",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

AU - Thiele, Swantje

AU - Stanelle-Bertram, Stephanie

AU - Beck, Sebastian

AU - Kouassi, Nancy Mounogou

AU - Zickler, Martin

AU - Müller, Martin

AU - Tuku, Berfin

AU - Resa-Infante, Patricia

AU - van Riel, Debby

AU - Alawi, Malik

AU - Günther, Thomas

AU - Rother, Franziska

AU - Hügel, Stefanie

AU - Reimering, Susanne

AU - McHardy, Alice

AU - Grundhoff, Adam

AU - Brune, Wolfram

AU - Osterhaus, Albert

AU - Bader, Michael

AU - Hartmann, Enno

AU - Gabriel, Gülsah

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor in the mammalian respiratory tract. Importin-α3 promoter activity is regulated by TNF-α-induced NF-κB in a concentration-dependent manner. High-level TNF-α-inducing highly pathogenic avian influenza A viruses (HPAIVs) isolated from fatal human cases harboring human-type polymerase signatures (PB2 627K, 701N) significantly downregulate importin-α3 mRNA expression in primary lung cells. Importin-α3 depletion is restored upon back-mutating the HPAIV polymerase into an avian-type signature (PB2 627E, 701D) that can no longer induce high TNF-α levels. Importin-α3-deficient mice show reduced NF-κB-activated antiviral gene expression and increased influenza lethality. Thus, importin-α3 plays a key role in antiviral immunity against influenza. Lifting the bottleneck in importin-α3 availability in the lung might provide a new strategy to combat respiratory virus infections.

AB - Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor in the mammalian respiratory tract. Importin-α3 promoter activity is regulated by TNF-α-induced NF-κB in a concentration-dependent manner. High-level TNF-α-inducing highly pathogenic avian influenza A viruses (HPAIVs) isolated from fatal human cases harboring human-type polymerase signatures (PB2 627K, 701N) significantly downregulate importin-α3 mRNA expression in primary lung cells. Importin-α3 depletion is restored upon back-mutating the HPAIV polymerase into an avian-type signature (PB2 627E, 701D) that can no longer induce high TNF-α levels. Importin-α3-deficient mice show reduced NF-κB-activated antiviral gene expression and increased influenza lethality. Thus, importin-α3 plays a key role in antiviral immunity against influenza. Lifting the bottleneck in importin-α3 availability in the lung might provide a new strategy to combat respiratory virus infections.

U2 - 10.1016/j.celrep.2020.107549

DO - 10.1016/j.celrep.2020.107549

M3 - SCORING: Journal article

C2 - 32320654

VL - 31

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 3

M1 - 107549

ER -