Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP

Anna B Ziegler; Christoph Thiele; Federico Tenedini; Mélisande Richard; Philipp Leyendecker; Astrid Hoermann; Peter Soba; Gaia Tavosanis

doi:10.1016/j.celrep.2017.11.069

Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP

Standard

Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. / Ziegler, Anna B; Thiele, Christoph; Tenedini, Federico; Richard, Mélisande; Leyendecker, Philipp; Hoermann, Astrid; Soba, Peter; Tavosanis, Gaia.

in: CELL REP, Jahrgang 21, Nr. 12, 19.12.2017, S. 3346-3353.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ziegler, AB, Thiele, C, Tenedini, F, Richard, M, Leyendecker, P, Hoermann, A, Soba, P & Tavosanis, G 2017, 'Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP', CELL REP, Jg. 21, Nr. 12, S. 3346-3353. https://doi.org/10.1016/j.celrep.2017.11.069

APA

Ziegler, A. B., Thiele, C., Tenedini, F., Richard, M., Leyendecker, P., Hoermann, A., Soba, P., & Tavosanis, G. (2017). Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. CELL REP, 21(12), 3346-3353. https://doi.org/10.1016/j.celrep.2017.11.069

Vancouver

Ziegler AB, Thiele C, Tenedini F, Richard M, Leyendecker P, Hoermann A et al. Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. CELL REP. 2017 Dez 19;21(12):3346-3353. https://doi.org/10.1016/j.celrep.2017.11.069

Bibtex

@article{9605fb2d60ce498e8ba5806af97852ea,

title = "Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP",

abstract = "During differentiation, neurons require a high lipid supply for membrane formation as they elaborate complex dendritic morphologies. While glia-derived lipids support neuronal growth during development, the importance of cell-autonomous lipid production for dendrite formation has been unclear. Using Drosophila larva dendritic arborization (da) neurons, we show that dendrite expansion relies on cell-autonomous fatty acid production. The nociceptive class four (CIV) da neurons form particularly large space-filling dendrites. We show that dendrite formation in these CIVda neurons additionally requires functional sterol regulatory element binding protein (SREBP), a crucial regulator of fatty acid production. The dendrite simplification in srebp mutant CIVda neurons is accompanied by hypersensitivity of srebp mutant larvae to noxious stimuli. Taken together, our work reveals that cell-autonomous fatty acid production is required for proper dendritic development and establishes the role of SREBP in complex neurons for dendrite elaboration and function.",

keywords = "Journal Article",

author = "Ziegler, {Anna B} and Christoph Thiele and Federico Tenedini and M{\'e}lisande Richard and Philipp Leyendecker and Astrid Hoermann and Peter Soba and Gaia Tavosanis",

year = "2017",

month = dec,

day = "19",

doi = "10.1016/j.celrep.2017.11.069",

language = "English",

volume = "21",

pages = "3346--3353",

journal = "CELL REP",

issn = "2211-1247",

publisher = "Elsevier",

number = "12",

}

RIS

TY - JOUR

T1 - Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP

AU - Ziegler, Anna B

AU - Thiele, Christoph

AU - Tenedini, Federico

AU - Richard, Mélisande

AU - Leyendecker, Philipp

AU - Hoermann, Astrid

AU - Soba, Peter

AU - Tavosanis, Gaia

PY - 2017/12/19

Y1 - 2017/12/19

N2 - During differentiation, neurons require a high lipid supply for membrane formation as they elaborate complex dendritic morphologies. While glia-derived lipids support neuronal growth during development, the importance of cell-autonomous lipid production for dendrite formation has been unclear. Using Drosophila larva dendritic arborization (da) neurons, we show that dendrite expansion relies on cell-autonomous fatty acid production. The nociceptive class four (CIV) da neurons form particularly large space-filling dendrites. We show that dendrite formation in these CIVda neurons additionally requires functional sterol regulatory element binding protein (SREBP), a crucial regulator of fatty acid production. The dendrite simplification in srebp mutant CIVda neurons is accompanied by hypersensitivity of srebp mutant larvae to noxious stimuli. Taken together, our work reveals that cell-autonomous fatty acid production is required for proper dendritic development and establishes the role of SREBP in complex neurons for dendrite elaboration and function.

AB - During differentiation, neurons require a high lipid supply for membrane formation as they elaborate complex dendritic morphologies. While glia-derived lipids support neuronal growth during development, the importance of cell-autonomous lipid production for dendrite formation has been unclear. Using Drosophila larva dendritic arborization (da) neurons, we show that dendrite expansion relies on cell-autonomous fatty acid production. The nociceptive class four (CIV) da neurons form particularly large space-filling dendrites. We show that dendrite formation in these CIVda neurons additionally requires functional sterol regulatory element binding protein (SREBP), a crucial regulator of fatty acid production. The dendrite simplification in srebp mutant CIVda neurons is accompanied by hypersensitivity of srebp mutant larvae to noxious stimuli. Taken together, our work reveals that cell-autonomous fatty acid production is required for proper dendritic development and establishes the role of SREBP in complex neurons for dendrite elaboration and function.

KW - Journal Article

U2 - 10.1016/j.celrep.2017.11.069

DO - 10.1016/j.celrep.2017.11.069

M3 - SCORING: Journal article

C2 - 29262315

VL - 21

SP - 3346

EP - 3353

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 12

ER -