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Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen

Standard

Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. / Renné, T; Müller-Esterl, W.

in: FEBS LETT, Jahrgang 500, Nr. 1-2, 29.06.2001, S. 36-40.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Renné, T & Müller-Esterl, W 2001, 'Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen', FEBS LETT, Jg. 500, Nr. 1-2, S. 36-40.

APA

Renné, T., & Müller-Esterl, W. (2001). Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS LETT, 500(1-2), 36-40.

Vancouver

Renné T, Müller-Esterl W. Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS LETT. 2001 Jun 29;500(1-2):36-40.

Bibtex

@article{1917769c25f3454b9a02da661c9ca817,
title = "Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen",
abstract = "The kinin system has been recognized as a locally operating hormone system of cardiovascular cells, however, the molecular mechanisms regulating circumscribed kinin release on cell surfaces are not fully understood. In particular, the principal cell docking sites for the kinin precursor, high molecular weight kininogen (HK), are not fully explored. Here we demonstrate by enzymatic digestion, recombinant overexpression, and affinity cross-linking studies that cell surface chondroitin sulfate (CS) chains of proteoglycans (PGs) serve as major HK binding sites on platelet, fibroblast, liver, and endothelial kidney cells. In this way, CS-type PGs may contribute to a local accumulation of kinin precursors on cell surfaces and modulate circumscribed release of short-lived kinin hormones at or next to their site of action.",
keywords = "Animals, Blood Platelets, COS Cells, Cells, Cultured, Chondroitin Sulfate Proteoglycans, Chondroitin Sulfates, Fibroblasts, Humans, Kininogen, High-Molecular-Weight",
author = "T Renn{\'e} and W M{\"u}ller-Esterl",
year = "2001",
month = jun,
day = "29",
language = "English",
volume = "500",
pages = "36--40",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen

AU - Renné, T

AU - Müller-Esterl, W

PY - 2001/6/29

Y1 - 2001/6/29

N2 - The kinin system has been recognized as a locally operating hormone system of cardiovascular cells, however, the molecular mechanisms regulating circumscribed kinin release on cell surfaces are not fully understood. In particular, the principal cell docking sites for the kinin precursor, high molecular weight kininogen (HK), are not fully explored. Here we demonstrate by enzymatic digestion, recombinant overexpression, and affinity cross-linking studies that cell surface chondroitin sulfate (CS) chains of proteoglycans (PGs) serve as major HK binding sites on platelet, fibroblast, liver, and endothelial kidney cells. In this way, CS-type PGs may contribute to a local accumulation of kinin precursors on cell surfaces and modulate circumscribed release of short-lived kinin hormones at or next to their site of action.

AB - The kinin system has been recognized as a locally operating hormone system of cardiovascular cells, however, the molecular mechanisms regulating circumscribed kinin release on cell surfaces are not fully understood. In particular, the principal cell docking sites for the kinin precursor, high molecular weight kininogen (HK), are not fully explored. Here we demonstrate by enzymatic digestion, recombinant overexpression, and affinity cross-linking studies that cell surface chondroitin sulfate (CS) chains of proteoglycans (PGs) serve as major HK binding sites on platelet, fibroblast, liver, and endothelial kidney cells. In this way, CS-type PGs may contribute to a local accumulation of kinin precursors on cell surfaces and modulate circumscribed release of short-lived kinin hormones at or next to their site of action.

KW - Animals

KW - Blood Platelets

KW - COS Cells

KW - Cells, Cultured

KW - Chondroitin Sulfate Proteoglycans

KW - Chondroitin Sulfates

KW - Fibroblasts

KW - Humans

KW - Kininogen, High-Molecular-Weight

M3 - SCORING: Journal article

C2 - 11434922

VL - 500

SP - 36

EP - 40

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 1-2

ER -