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Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation.

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Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation. / Li, Ya-Li; Wu, Guang-Zhi; Zeng, Li; Dawe, Gavin S; Sun, Li; Loers, Gabriele; Tilling, Thomas; Cui, Shu-Sen; Schachner, Melitta; Xiao, Zhi-Cheng.

in: FEBS LETT, Jahrgang 583, Nr. 4, 4, 2009, S. 703-710.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, Y-L, Wu, G-Z, Zeng, L, Dawe, GS, Sun, L, Loers, G, Tilling, T, Cui, S-S, Schachner, M & Xiao, Z-C 2009, 'Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation.', FEBS LETT, Jg. 583, Nr. 4, 4, S. 703-710. <http://www.ncbi.nlm.nih.gov/pubmed/19166842?dopt=Citation>

APA

Li, Y-L., Wu, G-Z., Zeng, L., Dawe, G. S., Sun, L., Loers, G., Tilling, T., Cui, S-S., Schachner, M., & Xiao, Z-C. (2009). Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation. FEBS LETT, 583(4), 703-710. [4]. http://www.ncbi.nlm.nih.gov/pubmed/19166842?dopt=Citation

Vancouver

Li Y-L, Wu G-Z, Zeng L, Dawe GS, Sun L, Loers G et al. Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation. FEBS LETT. 2009;583(4):703-710. 4.

Bibtex

@article{3d1c6e8f1cf049afbbec5a5a7573c4b4,
title = "Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation.",
abstract = "Cell surface glycosylation patterns are markers of cell type and status. However, the mechanisms regulating surface glycosylation patterns remain unknown. Using a panel of carbohydrate markers, we have shown that cell surface sialylation and fucosylation are upregulated in L1-transfected embryonic stem cells (L1-ESCs). Consistently, the mRNA levels of sialyltransferase ST6Gal1 and ST3Gal4, and fucosyltransferase FUT9 were significantly increased in L1-transfected ESCs. Activation of L1 signaling promoted cell survival and inhibited cell proliferation. ShRNAs knocking down FUT9, ST6Gal1 and ST3Gal4 blocked these effects. A phospholipase Cgamma (PLCgamma) inhibitor and shRNA reduced ST6Gal1, ST3Gal4 and FUT9 mRNA levels in the L1-ESCs. Thus, embryonic stem cell surface sialylation and fucosylation are regulated via PLCgamma by L1, with which they cooperate to modulate cell survival and proliferation.",
author = "Ya-Li Li and Guang-Zhi Wu and Li Zeng and Dawe, {Gavin S} and Li Sun and Gabriele Loers and Thomas Tilling and Shu-Sen Cui and Melitta Schachner and Zhi-Cheng Xiao",
year = "2009",
language = "Deutsch",
volume = "583",
pages = "703--710",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation.

AU - Li, Ya-Li

AU - Wu, Guang-Zhi

AU - Zeng, Li

AU - Dawe, Gavin S

AU - Sun, Li

AU - Loers, Gabriele

AU - Tilling, Thomas

AU - Cui, Shu-Sen

AU - Schachner, Melitta

AU - Xiao, Zhi-Cheng

PY - 2009

Y1 - 2009

N2 - Cell surface glycosylation patterns are markers of cell type and status. However, the mechanisms regulating surface glycosylation patterns remain unknown. Using a panel of carbohydrate markers, we have shown that cell surface sialylation and fucosylation are upregulated in L1-transfected embryonic stem cells (L1-ESCs). Consistently, the mRNA levels of sialyltransferase ST6Gal1 and ST3Gal4, and fucosyltransferase FUT9 were significantly increased in L1-transfected ESCs. Activation of L1 signaling promoted cell survival and inhibited cell proliferation. ShRNAs knocking down FUT9, ST6Gal1 and ST3Gal4 blocked these effects. A phospholipase Cgamma (PLCgamma) inhibitor and shRNA reduced ST6Gal1, ST3Gal4 and FUT9 mRNA levels in the L1-ESCs. Thus, embryonic stem cell surface sialylation and fucosylation are regulated via PLCgamma by L1, with which they cooperate to modulate cell survival and proliferation.

AB - Cell surface glycosylation patterns are markers of cell type and status. However, the mechanisms regulating surface glycosylation patterns remain unknown. Using a panel of carbohydrate markers, we have shown that cell surface sialylation and fucosylation are upregulated in L1-transfected embryonic stem cells (L1-ESCs). Consistently, the mRNA levels of sialyltransferase ST6Gal1 and ST3Gal4, and fucosyltransferase FUT9 were significantly increased in L1-transfected ESCs. Activation of L1 signaling promoted cell survival and inhibited cell proliferation. ShRNAs knocking down FUT9, ST6Gal1 and ST3Gal4 blocked these effects. A phospholipase Cgamma (PLCgamma) inhibitor and shRNA reduced ST6Gal1, ST3Gal4 and FUT9 mRNA levels in the L1-ESCs. Thus, embryonic stem cell surface sialylation and fucosylation are regulated via PLCgamma by L1, with which they cooperate to modulate cell survival and proliferation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 583

SP - 703

EP - 710

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 4

M1 - 4

ER -