Cell biology and clinical implications of adhesion molecules in colorectal diseases

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Cell biology and clinical implications of adhesion molecules in colorectal diseases : colorectal cancers, infections and inflammatory bowel diseases. / Haier, J; Nicolson, G L.

in: CLIN EXP METASTAS, Jahrgang 18, Nr. 8, 2000, S. 623-38.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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Bibtex

@article{cfd8b48f91f84e4e9ab1a30d59412206,
title = "Cell biology and clinical implications of adhesion molecules in colorectal diseases: colorectal cancers, infections and inflammatory bowel diseases",
abstract = "Adhesion molecules are transmembrane proteins that can anchor cytoskeletal proteins on the cytoplasmic side of the cell membrane, while also connecting extracellular structures on the outer surface of the cell membrane. In addition to physical linkages between the extracellular environment and the cytoskeleton, adhesive complexes participate in important signal transduction systems as modulators or receptors. Their functions in cell signaling are probably at least as important as their cytoskeletal and cell attachment properties. Understanding these regulatory functions appears to be of importance in determining of pathological characteristic of numerous diseases. Expression and functional activity of various adhesion molecules have been found in different diseases affecting the colorectum. In this review we summarize recent advantages about the cell biology these diseases and clinical implications.",
keywords = "Biology, Cell Adhesion, Cell Adhesion Molecules, Humans, Intestinal Diseases, Signal Transduction",
author = "J Haier and Nicolson, {G L}",
year = "2000",
language = "English",
volume = "18",
pages = "623--38",
journal = "CLIN EXP METASTAS",
issn = "0262-0898",
publisher = "Springer Netherlands",
number = "8",

}

RIS

TY - JOUR

T1 - Cell biology and clinical implications of adhesion molecules in colorectal diseases

T2 - colorectal cancers, infections and inflammatory bowel diseases

AU - Haier, J

AU - Nicolson, G L

PY - 2000

Y1 - 2000

N2 - Adhesion molecules are transmembrane proteins that can anchor cytoskeletal proteins on the cytoplasmic side of the cell membrane, while also connecting extracellular structures on the outer surface of the cell membrane. In addition to physical linkages between the extracellular environment and the cytoskeleton, adhesive complexes participate in important signal transduction systems as modulators or receptors. Their functions in cell signaling are probably at least as important as their cytoskeletal and cell attachment properties. Understanding these regulatory functions appears to be of importance in determining of pathological characteristic of numerous diseases. Expression and functional activity of various adhesion molecules have been found in different diseases affecting the colorectum. In this review we summarize recent advantages about the cell biology these diseases and clinical implications.

AB - Adhesion molecules are transmembrane proteins that can anchor cytoskeletal proteins on the cytoplasmic side of the cell membrane, while also connecting extracellular structures on the outer surface of the cell membrane. In addition to physical linkages between the extracellular environment and the cytoskeleton, adhesive complexes participate in important signal transduction systems as modulators or receptors. Their functions in cell signaling are probably at least as important as their cytoskeletal and cell attachment properties. Understanding these regulatory functions appears to be of importance in determining of pathological characteristic of numerous diseases. Expression and functional activity of various adhesion molecules have been found in different diseases affecting the colorectum. In this review we summarize recent advantages about the cell biology these diseases and clinical implications.

KW - Biology

KW - Cell Adhesion

KW - Cell Adhesion Molecules

KW - Humans

KW - Intestinal Diseases

KW - Signal Transduction

M3 - SCORING: Journal article

C2 - 11827066

VL - 18

SP - 623

EP - 638

JO - CLIN EXP METASTAS

JF - CLIN EXP METASTAS

SN - 0262-0898

IS - 8

ER -