Cell biology and clinical implications of adhesion molecules in colorectal diseases
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Cell biology and clinical implications of adhesion molecules in colorectal diseases : colorectal cancers, infections and inflammatory bowel diseases. / Haier, J; Nicolson, G L.
in: CLIN EXP METASTAS, Jahrgang 18, Nr. 8, 2000, S. 623-38.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cell biology and clinical implications of adhesion molecules in colorectal diseases
T2 - colorectal cancers, infections and inflammatory bowel diseases
AU - Haier, J
AU - Nicolson, G L
PY - 2000
Y1 - 2000
N2 - Adhesion molecules are transmembrane proteins that can anchor cytoskeletal proteins on the cytoplasmic side of the cell membrane, while also connecting extracellular structures on the outer surface of the cell membrane. In addition to physical linkages between the extracellular environment and the cytoskeleton, adhesive complexes participate in important signal transduction systems as modulators or receptors. Their functions in cell signaling are probably at least as important as their cytoskeletal and cell attachment properties. Understanding these regulatory functions appears to be of importance in determining of pathological characteristic of numerous diseases. Expression and functional activity of various adhesion molecules have been found in different diseases affecting the colorectum. In this review we summarize recent advantages about the cell biology these diseases and clinical implications.
AB - Adhesion molecules are transmembrane proteins that can anchor cytoskeletal proteins on the cytoplasmic side of the cell membrane, while also connecting extracellular structures on the outer surface of the cell membrane. In addition to physical linkages between the extracellular environment and the cytoskeleton, adhesive complexes participate in important signal transduction systems as modulators or receptors. Their functions in cell signaling are probably at least as important as their cytoskeletal and cell attachment properties. Understanding these regulatory functions appears to be of importance in determining of pathological characteristic of numerous diseases. Expression and functional activity of various adhesion molecules have been found in different diseases affecting the colorectum. In this review we summarize recent advantages about the cell biology these diseases and clinical implications.
KW - Biology
KW - Cell Adhesion
KW - Cell Adhesion Molecules
KW - Humans
KW - Intestinal Diseases
KW - Signal Transduction
M3 - SCORING: Journal article
C2 - 11827066
VL - 18
SP - 623
EP - 638
JO - CLIN EXP METASTAS
JF - CLIN EXP METASTAS
SN - 0262-0898
IS - 8
ER -