Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut.
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Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut. / Turner, Kirsty N; Schachner, Melitta; Anderson, Richard B.
in: DEV DYNAM, Jahrgang 238, Nr. 3, 3, 2009, S. 708-715.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut.
AU - Turner, Kirsty N
AU - Schachner, Melitta
AU - Anderson, Richard B
PY - 2009
Y1 - 2009
N2 - The enteric nervous system arises predominantly from vagal level neural crest cells that migrate into and along the developing gut. As the neural crest-derived cells migrate within the gut, a subpopulation begins to differentiate into enteric neurons. Here, we show that the differentiation of neural crest-derived cells into enteric neurons is delayed in L1-deficient mice, compared with littermate controls. However, glial cell differentiation is not affected in L1-deficient mice. These mice also show a delay in the differentiation of a neurotransmitter-specific subtype of enteric neuron within the gastrointestinal tract. Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system.
AB - The enteric nervous system arises predominantly from vagal level neural crest cells that migrate into and along the developing gut. As the neural crest-derived cells migrate within the gut, a subpopulation begins to differentiate into enteric neurons. Here, we show that the differentiation of neural crest-derived cells into enteric neurons is delayed in L1-deficient mice, compared with littermate controls. However, glial cell differentiation is not affected in L1-deficient mice. These mice also show a delay in the differentiation of a neurotransmitter-specific subtype of enteric neuron within the gastrointestinal tract. Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 238
SP - 708
EP - 715
JO - DEV DYNAM
JF - DEV DYNAM
SN - 1058-8388
IS - 3
M1 - 3
ER -
