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CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.

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CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. / Ergün, S; Kilik, N; Ziegeler, G; Hansen, A; Nollau, P; Götze, J; Wurmbach, J H; Horst, Andrea; Weil, J; Fernando, M; Wagener, C.

in: MOL CELL, Jahrgang 5, Nr. 2, 2, 2000, S. 311-320.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ergün, S, Kilik, N, Ziegeler, G, Hansen, A, Nollau, P, Götze, J, Wurmbach, JH, Horst, A, Weil, J, Fernando, M & Wagener, C 2000, 'CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.', MOL CELL, Jg. 5, Nr. 2, 2, S. 311-320. <http://www.ncbi.nlm.nih.gov/pubmed/10882072?dopt=Citation>

APA

Ergün, S., Kilik, N., Ziegeler, G., Hansen, A., Nollau, P., Götze, J., Wurmbach, J. H., Horst, A., Weil, J., Fernando, M., & Wagener, C. (2000). CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. MOL CELL, 5(2), 311-320. [2]. http://www.ncbi.nlm.nih.gov/pubmed/10882072?dopt=Citation

Vancouver

Ergün S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J et al. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. MOL CELL. 2000;5(2):311-320. 2.

Bibtex

@article{7d217cbbb4314726b1c416a64e5083dd,
title = "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.",
abstract = "CEA-related cell adhesion molecule 1 (CEACAM1) exhibits angiogenic properties in in vitro and in vivo angiogenesis assays. CEACAM1 purified from granulocytes and endothelial cell media as well as recombinant CEACAM1 expressed in HEK293 cells stimulate proliferation, chemotaxis, and capillary-like tube formation of human microvascular endothelial cells. They increase vascularization of chick chorioallantoic membrane and potentiate the effects of vascular endothelial growth factor (VEGF)165. VEGF165 increases CEACAM1 expression both on the mRNA and the protein level. VEGF165-induced endothelial tube formation is blocked by a monoclonal CEACAM1 antibody. These data suggest that CEACAM1 is a major effector of VEGF in the early microvessel formation. Since CEACAM1 is expressed in tumor microvessels but not in large blood vessels, CEACAM1 may be a target for the inhibition of tumor angiogenesis.",
author = "S Erg{\"u}n and N Kilik and G Ziegeler and A Hansen and P Nollau and J G{\"o}tze and Wurmbach, {J H} and Andrea Horst and J Weil and M Fernando and C Wagener",
year = "2000",
language = "Deutsch",
volume = "5",
pages = "311--320",
journal = "MOL CELL",
issn = "1097-2765",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.

AU - Ergün, S

AU - Kilik, N

AU - Ziegeler, G

AU - Hansen, A

AU - Nollau, P

AU - Götze, J

AU - Wurmbach, J H

AU - Horst, Andrea

AU - Weil, J

AU - Fernando, M

AU - Wagener, C

PY - 2000

Y1 - 2000

N2 - CEA-related cell adhesion molecule 1 (CEACAM1) exhibits angiogenic properties in in vitro and in vivo angiogenesis assays. CEACAM1 purified from granulocytes and endothelial cell media as well as recombinant CEACAM1 expressed in HEK293 cells stimulate proliferation, chemotaxis, and capillary-like tube formation of human microvascular endothelial cells. They increase vascularization of chick chorioallantoic membrane and potentiate the effects of vascular endothelial growth factor (VEGF)165. VEGF165 increases CEACAM1 expression both on the mRNA and the protein level. VEGF165-induced endothelial tube formation is blocked by a monoclonal CEACAM1 antibody. These data suggest that CEACAM1 is a major effector of VEGF in the early microvessel formation. Since CEACAM1 is expressed in tumor microvessels but not in large blood vessels, CEACAM1 may be a target for the inhibition of tumor angiogenesis.

AB - CEA-related cell adhesion molecule 1 (CEACAM1) exhibits angiogenic properties in in vitro and in vivo angiogenesis assays. CEACAM1 purified from granulocytes and endothelial cell media as well as recombinant CEACAM1 expressed in HEK293 cells stimulate proliferation, chemotaxis, and capillary-like tube formation of human microvascular endothelial cells. They increase vascularization of chick chorioallantoic membrane and potentiate the effects of vascular endothelial growth factor (VEGF)165. VEGF165 increases CEACAM1 expression both on the mRNA and the protein level. VEGF165-induced endothelial tube formation is blocked by a monoclonal CEACAM1 antibody. These data suggest that CEACAM1 is a major effector of VEGF in the early microvessel formation. Since CEACAM1 is expressed in tumor microvessels but not in large blood vessels, CEACAM1 may be a target for the inhibition of tumor angiogenesis.

M3 - SCORING: Zeitschriftenaufsatz

VL - 5

SP - 311

EP - 320

JO - MOL CELL

JF - MOL CELL

SN - 1097-2765

IS - 2

M1 - 2

ER -