CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease.
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CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. / Dahl, Anka; Moll, Ingrid; Berger, Jürgen; Wagener, Christoph; Brümmer, Jens; Schulze, Hans-Joachim; Brunner, Georg; Schumacher, Udo.
in: J CLIN ONCOL, Jahrgang 20, Nr. 10, 10, 2002, S. 2530-2536.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease.
AU - Dahl, Anka
AU - Moll, Ingrid
AU - Berger, Jürgen
AU - Wagener, Christoph
AU - Brümmer, Jens
AU - Schulze, Hans-Joachim
AU - Brunner, Georg
AU - Schumacher, Udo
PY - 2002
Y1 - 2002
N2 - PURPOSE: The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis. PATIENTS AND METHODS: CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression. RESULTS: A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P
AB - PURPOSE: The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis. PATIENTS AND METHODS: CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression. RESULTS: A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 2530
EP - 2536
JO - J CLIN ONCOL
JF - J CLIN ONCOL
SN - 0732-183X
IS - 10
M1 - 10
ER -
