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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. / Schneider, Enja; Winzer, Riekje; Rissiek, Anne; Ricklefs, Isabell; Meyer-Schwesinger, Catherine; Ricklefs, Franz L; Bauche, Andreas; Behrends, Jochen; Reimer, Rudolph; Brenna, Santra; Wasielewski, Hauke; Lauten, Melchior; Rissiek, Björn; Puig, Berta; Cortesi, Filippo; Magnus, Tim; Fliegert, Ralf; Müller, Christa E; Gagliani, Nicola; Tolosa, Eva.

in: NAT COMMUN, Jahrgang 12, Nr. 1, 08.10.2021, S. 5911.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schneider, E, Winzer, R, Rissiek, A, Ricklefs, I, Meyer-Schwesinger, C, Ricklefs, FL, Bauche, A, Behrends, J, Reimer, R, Brenna, S, Wasielewski, H, Lauten, M, Rissiek, B, Puig, B, Cortesi, F, Magnus, T, Fliegert, R, Müller, CE, Gagliani, N & Tolosa, E 2021, 'CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression', NAT COMMUN, Jg. 12, Nr. 1, S. 5911. https://doi.org/10.1038/s41467-021-26134-w

APA

Schneider, E., Winzer, R., Rissiek, A., Ricklefs, I., Meyer-Schwesinger, C., Ricklefs, F. L., Bauche, A., Behrends, J., Reimer, R., Brenna, S., Wasielewski, H., Lauten, M., Rissiek, B., Puig, B., Cortesi, F., Magnus, T., Fliegert, R., Müller, C. E., Gagliani, N., & Tolosa, E. (2021). CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. NAT COMMUN, 12(1), 5911. https://doi.org/10.1038/s41467-021-26134-w

Vancouver

Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs FL et al. CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. NAT COMMUN. 2021 Okt 8;12(1):5911. https://doi.org/10.1038/s41467-021-26134-w

Bibtex

@article{f48dd89052b9460cad77fb6a675c3b9b,
title = "CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression",
abstract = "Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. The stepwise hydrolysis of extracellular ATP by ectonucleotidases CD39 and CD73 generates adenosine, a potent immune suppressor. Here we report that human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles upon activation. These extracellular vesicles have AMPase activity, and the resulting adenosine mediates immune suppression independently of regulatory T cells. In addition, we show that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner. Our results suggest that the generation of adenosine upon T cell activation is an intrinsic mechanism of human effector T cells that complements regulatory T cell-mediated suppression in the inflamed tissue. Finally, our data underscore the role of immune cell-derived extracellular vesicles in the control of immune responses.",
author = "Enja Schneider and Riekje Winzer and Anne Rissiek and Isabell Ricklefs and Catherine Meyer-Schwesinger and Ricklefs, {Franz L} and Andreas Bauche and Jochen Behrends and Rudolph Reimer and Santra Brenna and Hauke Wasielewski and Melchior Lauten and Bj{\"o}rn Rissiek and Berta Puig and Filippo Cortesi and Tim Magnus and Ralf Fliegert and M{\"u}ller, {Christa E} and Nicola Gagliani and Eva Tolosa",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = oct,
day = "8",
doi = "10.1038/s41467-021-26134-w",
language = "English",
volume = "12",
pages = "5911",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

AU - Schneider, Enja

AU - Winzer, Riekje

AU - Rissiek, Anne

AU - Ricklefs, Isabell

AU - Meyer-Schwesinger, Catherine

AU - Ricklefs, Franz L

AU - Bauche, Andreas

AU - Behrends, Jochen

AU - Reimer, Rudolph

AU - Brenna, Santra

AU - Wasielewski, Hauke

AU - Lauten, Melchior

AU - Rissiek, Björn

AU - Puig, Berta

AU - Cortesi, Filippo

AU - Magnus, Tim

AU - Fliegert, Ralf

AU - Müller, Christa E

AU - Gagliani, Nicola

AU - Tolosa, Eva

N1 - © 2021. The Author(s).

PY - 2021/10/8

Y1 - 2021/10/8

N2 - Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. The stepwise hydrolysis of extracellular ATP by ectonucleotidases CD39 and CD73 generates adenosine, a potent immune suppressor. Here we report that human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles upon activation. These extracellular vesicles have AMPase activity, and the resulting adenosine mediates immune suppression independently of regulatory T cells. In addition, we show that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner. Our results suggest that the generation of adenosine upon T cell activation is an intrinsic mechanism of human effector T cells that complements regulatory T cell-mediated suppression in the inflamed tissue. Finally, our data underscore the role of immune cell-derived extracellular vesicles in the control of immune responses.

AB - Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. The stepwise hydrolysis of extracellular ATP by ectonucleotidases CD39 and CD73 generates adenosine, a potent immune suppressor. Here we report that human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles upon activation. These extracellular vesicles have AMPase activity, and the resulting adenosine mediates immune suppression independently of regulatory T cells. In addition, we show that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner. Our results suggest that the generation of adenosine upon T cell activation is an intrinsic mechanism of human effector T cells that complements regulatory T cell-mediated suppression in the inflamed tissue. Finally, our data underscore the role of immune cell-derived extracellular vesicles in the control of immune responses.

U2 - 10.1038/s41467-021-26134-w

DO - 10.1038/s41467-021-26134-w

M3 - SCORING: Journal article

C2 - 34625545

VL - 12

SP - 5911

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -