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CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival

Standard

CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. / Yogev, Nir; Bedke, Tanja; Kobayashi, Yasushi; Brockmann, Leonie; Lukas, Dominika; Regen, Tommy; Croxford, Andrew L; Nikolav, Alexei; Hövelmeyer, Nadine; von Stebut, Esther; Prinz, Marco; Ubeda, Carles; Maloy, Kevin J; Gagliani, Nicola; Flavell, Richard A; Waisman, Ari; Huber, Samuel.

in: CELL REP, Jahrgang 38, Nr. 13, 110565, 29.03.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Yogev, N, Bedke, T, Kobayashi, Y, Brockmann, L, Lukas, D, Regen, T, Croxford, AL, Nikolav, A, Hövelmeyer, N, von Stebut, E, Prinz, M, Ubeda, C, Maloy, KJ, Gagliani, N, Flavell, RA, Waisman, A & Huber, S 2022, 'CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival', CELL REP, Jg. 38, Nr. 13, 110565. https://doi.org/10.1016/j.celrep.2022.110565

APA

Yogev, N., Bedke, T., Kobayashi, Y., Brockmann, L., Lukas, D., Regen, T., Croxford, A. L., Nikolav, A., Hövelmeyer, N., von Stebut, E., Prinz, M., Ubeda, C., Maloy, K. J., Gagliani, N., Flavell, R. A., Waisman, A., & Huber, S. (2022). CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. CELL REP, 38(13), [110565]. https://doi.org/10.1016/j.celrep.2022.110565

Vancouver

Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T et al. CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. CELL REP. 2022 Mär 29;38(13). 110565. https://doi.org/10.1016/j.celrep.2022.110565

Bibtex

@article{985085ecbf5b4113b198b56f754aba41,
title = "CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival",
abstract = "Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, significantly contributing to the maintenance and reestablishment of immune homeostasis. Accordingly, it has been shown in the intestine that IL-10 produced by Tregs can act on effector T cells, thereby limiting inflammation. Herein, we investigate whether this role also applies to IL-10 produced by T cells during central nervous system (CNS) inflammation. During neuroinflammation, both CNS-resident and -infiltrating cells produce IL-10; yet, as IL-10 has a pleotropic function, the exact contribution of the different cellular sources is not fully understood. We find that T-cell-derived IL-10, but not other relevant IL-10 sources, can promote inflammation in experimental autoimmune encephalomyelitis. Furthermore, in the CNS, T-cell-derived IL-10 acts on effector T cells, promoting their survival and thereby enhancing inflammation and CNS autoimmunity. Our data indicate a pro-inflammatory role of T-cell-derived IL-10 in the CNS.",
keywords = "Animals, CD4-Positive T-Lymphocytes, Cell Survival, Central Nervous System, Inflammation, Interleukin-10/physiology, Mice, T-Lymphocytes",
author = "Nir Yogev and Tanja Bedke and Yasushi Kobayashi and Leonie Brockmann and Dominika Lukas and Tommy Regen and Croxford, {Andrew L} and Alexei Nikolav and Nadine H{\"o}velmeyer and {von Stebut}, Esther and Marco Prinz and Carles Ubeda and Maloy, {Kevin J} and Nicola Gagliani and Flavell, {Richard A} and Ari Waisman and Samuel Huber",
note = "Copyright {\textcopyright} 2022 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2022",
month = mar,
day = "29",
doi = "10.1016/j.celrep.2022.110565",
language = "English",
volume = "38",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "13",

}

RIS

TY - JOUR

T1 - CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival

AU - Yogev, Nir

AU - Bedke, Tanja

AU - Kobayashi, Yasushi

AU - Brockmann, Leonie

AU - Lukas, Dominika

AU - Regen, Tommy

AU - Croxford, Andrew L

AU - Nikolav, Alexei

AU - Hövelmeyer, Nadine

AU - von Stebut, Esther

AU - Prinz, Marco

AU - Ubeda, Carles

AU - Maloy, Kevin J

AU - Gagliani, Nicola

AU - Flavell, Richard A

AU - Waisman, Ari

AU - Huber, Samuel

N1 - Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2022/3/29

Y1 - 2022/3/29

N2 - Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, significantly contributing to the maintenance and reestablishment of immune homeostasis. Accordingly, it has been shown in the intestine that IL-10 produced by Tregs can act on effector T cells, thereby limiting inflammation. Herein, we investigate whether this role also applies to IL-10 produced by T cells during central nervous system (CNS) inflammation. During neuroinflammation, both CNS-resident and -infiltrating cells produce IL-10; yet, as IL-10 has a pleotropic function, the exact contribution of the different cellular sources is not fully understood. We find that T-cell-derived IL-10, but not other relevant IL-10 sources, can promote inflammation in experimental autoimmune encephalomyelitis. Furthermore, in the CNS, T-cell-derived IL-10 acts on effector T cells, promoting their survival and thereby enhancing inflammation and CNS autoimmunity. Our data indicate a pro-inflammatory role of T-cell-derived IL-10 in the CNS.

AB - Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, significantly contributing to the maintenance and reestablishment of immune homeostasis. Accordingly, it has been shown in the intestine that IL-10 produced by Tregs can act on effector T cells, thereby limiting inflammation. Herein, we investigate whether this role also applies to IL-10 produced by T cells during central nervous system (CNS) inflammation. During neuroinflammation, both CNS-resident and -infiltrating cells produce IL-10; yet, as IL-10 has a pleotropic function, the exact contribution of the different cellular sources is not fully understood. We find that T-cell-derived IL-10, but not other relevant IL-10 sources, can promote inflammation in experimental autoimmune encephalomyelitis. Furthermore, in the CNS, T-cell-derived IL-10 acts on effector T cells, promoting their survival and thereby enhancing inflammation and CNS autoimmunity. Our data indicate a pro-inflammatory role of T-cell-derived IL-10 in the CNS.

KW - Animals

KW - CD4-Positive T-Lymphocytes

KW - Cell Survival

KW - Central Nervous System

KW - Inflammation

KW - Interleukin-10/physiology

KW - Mice

KW - T-Lymphocytes

U2 - 10.1016/j.celrep.2022.110565

DO - 10.1016/j.celrep.2022.110565

M3 - SCORING: Journal article

C2 - 35354043

VL - 38

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 13

M1 - 110565

ER -