CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.
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CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia. / Choe, Chi-Un; Lardong, Kerstin; Gelderblom, Mathias; Ludewig, Peter; Leypoldt, Frank; Koch Nolte, Friedrich; Gerloff, Christian; Magnus, Tim.
in: PLOS ONE, Jahrgang 6, Nr. 5, 5, 2011, S. 19046.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.
AU - Choe, Chi-Un
AU - Lardong, Kerstin
AU - Gelderblom, Mathias
AU - Ludewig, Peter
AU - Leypoldt, Frank
AU - Koch Nolte, Friedrich
AU - Gerloff, Christian
AU - Magnus, Tim
PY - 2011
Y1 - 2011
N2 - Converging evidence suggests that inflammatory processes significantly influence brain injury and clinical impairment in ischemic stroke. Although early studies suggested a key role of lymphocytes, recent data has emphasized the orchestrating function of innate immunity, i.e., macrophages and microglia. The bifunctional receptor and ectoenzyme CD38 synthesizes calcium-mobilizing second messengers (e.g., cyclic ADP-ribose), which have been shown to be necessary for activation and migration of myeloid immune cells. Therefore, we investigated the dynamics of CD38 in stroke and the impact of CD38-deficiency on cytokine production, inflammation and cerebral damage in a mouse model of cerebral ischemia-reperfusion.
AB - Converging evidence suggests that inflammatory processes significantly influence brain injury and clinical impairment in ischemic stroke. Although early studies suggested a key role of lymphocytes, recent data has emphasized the orchestrating function of innate immunity, i.e., macrophages and microglia. The bifunctional receptor and ectoenzyme CD38 synthesizes calcium-mobilizing second messengers (e.g., cyclic ADP-ribose), which have been shown to be necessary for activation and migration of myeloid immune cells. Therefore, we investigated the dynamics of CD38 in stroke and the impact of CD38-deficiency on cytokine production, inflammation and cerebral damage in a mouse model of cerebral ischemia-reperfusion.
KW - Animals
KW - Humans
KW - Male
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Enzyme-Linked Immunosorbent Assay
KW - Mice, Transgenic
KW - Blotting, Western
KW - Immunoenzyme Techniques
KW - Bone Marrow Transplantation
KW - Antigens, CD38/physiology
KW - Brain Injuries/immunology/metabolism/prevention & control
KW - Brain Ischemia/etiology/pathology
KW - Cytokines/metabolism
KW - Infarction, Middle Cerebral Artery/etiology
KW - Inflammation/immunology/metabolism/prevention & control
KW - Lymphocytes/immunology/metabolism
KW - Macrophages/immunology/metabolism
KW - Membrane Glycoproteins/physiology
KW - Animals
KW - Humans
KW - Male
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Enzyme-Linked Immunosorbent Assay
KW - Mice, Transgenic
KW - Blotting, Western
KW - Immunoenzyme Techniques
KW - Bone Marrow Transplantation
KW - Antigens, CD38/physiology
KW - Brain Injuries/immunology/metabolism/prevention & control
KW - Brain Ischemia/etiology/pathology
KW - Cytokines/metabolism
KW - Infarction, Middle Cerebral Artery/etiology
KW - Inflammation/immunology/metabolism/prevention & control
KW - Lymphocytes/immunology/metabolism
KW - Macrophages/immunology/metabolism
KW - Membrane Glycoproteins/physiology
U2 - 10.1371/journal.pone.0019046
DO - 10.1371/journal.pone.0019046
M3 - SCORING: Journal article
VL - 6
SP - 19046
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 5
M1 - 5
ER -
