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CD38: a NAADP degrading enzyme.

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CD38: a NAADP degrading enzyme. / Schmid, Frederike; Bruhn, Sören; Weber, Karin; Mittrücker, Hans Willi; Guse, Andreas H.

in: FEBS LETT, Jahrgang 585, Nr. 22, 22, 2011, S. 3544-3548.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schmid, F, Bruhn, S, Weber, K, Mittrücker, HW & Guse, AH 2011, 'CD38: a NAADP degrading enzyme.', FEBS LETT, Jg. 585, Nr. 22, 22, S. 3544-3548. <http://www.ncbi.nlm.nih.gov/pubmed/22020217?dopt=Citation>

APA

Schmid, F., Bruhn, S., Weber, K., Mittrücker, H. W., & Guse, A. H. (2011). CD38: a NAADP degrading enzyme. FEBS LETT, 585(22), 3544-3548. [22]. http://www.ncbi.nlm.nih.gov/pubmed/22020217?dopt=Citation

Vancouver

Schmid F, Bruhn S, Weber K, Mittrücker HW, Guse AH. CD38: a NAADP degrading enzyme. FEBS LETT. 2011;585(22):3544-3548. 22.

Bibtex

@article{5ffc6385417a4e938ba8cf0f6bb68240,
title = "CD38: a NAADP degrading enzyme.",
abstract = "The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.",
keywords = "Animals, Humans, Mice, Mice, Knockout, Gene Silencing, Calcium/metabolism, Jurkat Cells, Adenosine Diphosphate Ribose/*metabolism, Antigens, CD38/*genetics/metabolism, Membrane Glycoproteins/*genetics/metabolism, NADP/*analogs & derivatives/metabolism, Spleen/metabolism, Thymus Gland/metabolism, Animals, Humans, Mice, Mice, Knockout, Gene Silencing, Calcium/metabolism, Jurkat Cells, Adenosine Diphosphate Ribose/*metabolism, Antigens, CD38/*genetics/metabolism, Membrane Glycoproteins/*genetics/metabolism, NADP/*analogs & derivatives/metabolism, Spleen/metabolism, Thymus Gland/metabolism",
author = "Frederike Schmid and S{\"o}ren Bruhn and Karin Weber and Mittr{\"u}cker, {Hans Willi} and Guse, {Andreas H.}",
year = "2011",
language = "English",
volume = "585",
pages = "3544--3548",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "22",

}

RIS

TY - JOUR

T1 - CD38: a NAADP degrading enzyme.

AU - Schmid, Frederike

AU - Bruhn, Sören

AU - Weber, Karin

AU - Mittrücker, Hans Willi

AU - Guse, Andreas H.

PY - 2011

Y1 - 2011

N2 - The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.

AB - The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.

KW - Animals

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Gene Silencing

KW - Calcium/metabolism

KW - Jurkat Cells

KW - Adenosine Diphosphate Ribose/metabolism

KW - Antigens, CD38/genetics/metabolism

KW - Membrane Glycoproteins/genetics/metabolism

KW - NADP/analogs & derivatives/metabolism

KW - Spleen/metabolism

KW - Thymus Gland/metabolism

KW - Animals

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Gene Silencing

KW - Calcium/metabolism

KW - Jurkat Cells

KW - Adenosine Diphosphate Ribose/metabolism

KW - Antigens, CD38/genetics/metabolism

KW - Membrane Glycoproteins/genetics/metabolism

KW - NADP/analogs & derivatives/metabolism

KW - Spleen/metabolism

KW - Thymus Gland/metabolism

M3 - SCORING: Journal article

VL - 585

SP - 3544

EP - 3548

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 22

M1 - 22

ER -