PortalPublikationenCD34+ selected stem cell boosts can improve poor graft funct...

CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation

Standard

CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation. / Mainardi, Chiara; Ebinger, Martin; Enkel, Sigrid; Feuchtinger, Tobias; Teltschik, Heiko-Manuel; Eyrich, Matthias; Schumm, Michael; Rabsteyn, Armin; Schlegel, Patrick; Seitz, Christian; Schwarze, Carl-Phillip; Müller, Ingo; Greil, Johann; Bader, Peter; Schlegel, Paul-Gerhardt; Martin, David; Holzer, Ursula; Döring, Michaela; Handgretinger, Rupert; Lang, Peter.

in: BRIT J HAEMATOL, Jahrgang 180, Nr. 1, 01.2018, S. 90-99.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mainardi, C, Ebinger, M, Enkel, S, Feuchtinger, T, Teltschik, H-M, Eyrich, M, Schumm, M, Rabsteyn, A, Schlegel, P, Seitz, C, Schwarze, C-P, Müller, I, Greil, J, Bader, P, Schlegel, P-G, Martin, D, Holzer, U, Döring, M, Handgretinger, R & Lang, P 2018, 'CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation', BRIT J HAEMATOL, Jg. 180, Nr. 1, S. 90-99. https://doi.org/10.1111/bjh.15012

APA

Mainardi, C., Ebinger, M., Enkel, S., Feuchtinger, T., Teltschik, H-M., Eyrich, M., Schumm, M., Rabsteyn, A., Schlegel, P., Seitz, C., Schwarze, C-P., Müller, I., Greil, J., Bader, P., Schlegel, P-G., Martin, D., Holzer, U., Döring, M., Handgretinger, R., & Lang, P. (2018). CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation. BRIT J HAEMATOL, 180(1), 90-99. https://doi.org/10.1111/bjh.15012

Vancouver

Mainardi C, Ebinger M, Enkel S, Feuchtinger T, Teltschik H-M, Eyrich M et al. CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation. BRIT J HAEMATOL. 2018 Jan;180(1):90-99. https://doi.org/10.1111/bjh.15012

Bibtex

@article{0741e55b1bb248489c223ee466c2505a,
title = "CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation",
abstract = "Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34+ selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 109 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and <0·001), were observed, and 78·8% of patients resolved one or two of their cytopenias. 36·5% had a complete haematological response. Median lymphocyte counts for CD3+ , CD3+ CD4+ , CD19+ and CD56+ increased 8·3-, 14·2-, 22.- and 1·6-fold. The rate of de novo acute graft-versus-host disease (GvHD) grade I-III was only 6% and resolved completely. No GvHD grade IV or chronic GvHD occurred. Patients who responded to SCB displayed a trend toward better overall survival (OS) (P = 0·07). Thus, administration of CD34+ selected SCBs from alternative donors is safe and effective. Further studies are warranted to clarify the impact on immune reconstitution and survival.",
keywords = "Journal Article",
author = "Chiara Mainardi and Martin Ebinger and Sigrid Enkel and Tobias Feuchtinger and Heiko-Manuel Teltschik and Matthias Eyrich and Michael Schumm and Armin Rabsteyn and Patrick Schlegel and Christian Seitz and Carl-Phillip Schwarze and Ingo M{\"u}ller and Johann Greil and Peter Bader and Paul-Gerhardt Schlegel and David Martin and Ursula Holzer and Michaela D{\"o}ring and Rupert Handgretinger and Peter Lang",
note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",
year = "2018",
month = jan,
doi = "10.1111/bjh.15012",
language = "English",
volume = "180",
pages = "90--99",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation

AU - Mainardi, Chiara

AU - Ebinger, Martin

AU - Enkel, Sigrid

AU - Feuchtinger, Tobias

AU - Teltschik, Heiko-Manuel

AU - Eyrich, Matthias

AU - Schumm, Michael

AU - Rabsteyn, Armin

AU - Schlegel, Patrick

AU - Seitz, Christian

AU - Schwarze, Carl-Phillip

AU - Müller, Ingo

AU - Greil, Johann

AU - Bader, Peter

AU - Schlegel, Paul-Gerhardt

AU - Martin, David

AU - Holzer, Ursula

AU - Döring, Michaela

AU - Handgretinger, Rupert

AU - Lang, Peter

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2018/1

Y1 - 2018/1

N2 - Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34+ selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 109 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and <0·001), were observed, and 78·8% of patients resolved one or two of their cytopenias. 36·5% had a complete haematological response. Median lymphocyte counts for CD3+ , CD3+ CD4+ , CD19+ and CD56+ increased 8·3-, 14·2-, 22.- and 1·6-fold. The rate of de novo acute graft-versus-host disease (GvHD) grade I-III was only 6% and resolved completely. No GvHD grade IV or chronic GvHD occurred. Patients who responded to SCB displayed a trend toward better overall survival (OS) (P = 0·07). Thus, administration of CD34+ selected SCBs from alternative donors is safe and effective. Further studies are warranted to clarify the impact on immune reconstitution and survival.

AB - Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34+ selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 109 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and <0·001), were observed, and 78·8% of patients resolved one or two of their cytopenias. 36·5% had a complete haematological response. Median lymphocyte counts for CD3+ , CD3+ CD4+ , CD19+ and CD56+ increased 8·3-, 14·2-, 22.- and 1·6-fold. The rate of de novo acute graft-versus-host disease (GvHD) grade I-III was only 6% and resolved completely. No GvHD grade IV or chronic GvHD occurred. Patients who responded to SCB displayed a trend toward better overall survival (OS) (P = 0·07). Thus, administration of CD34+ selected SCBs from alternative donors is safe and effective. Further studies are warranted to clarify the impact on immune reconstitution and survival.

KW - Journal Article

U2 - 10.1111/bjh.15012

DO - 10.1111/bjh.15012

M3 - SCORING: Journal article

C2 - 29205259

VL - 180

SP - 90

EP - 99

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 1

ER -