CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
Standard
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity. / Doehn, Jan-Moritz; Tabeling, Christoph; Biesen, Robert; Saccomanno, Jacopo; Madlung, Elena; Pappe, Eva; Gabriel, Frieder; Kurth, Florian; Meisel, Christian; Corman, Victor M; Hanitsch, Leif G; Treskatsch, Sascha; Heim, Kathrin; Stegemann, Miriam S; Ruwwe-Glösenkamp, Christoph; Müller-Redetzky, Holger C; Uhrig, Alexander; Somasundaram, Rajan; Spies, Claudia; von Bernuth, Horst; Hofmann, Jörg; Drosten, Christian; Suttorp, Norbert; Witzenrath, Martin; Sander, Leif E; Hübner, Ralf-Harto.
in: INFECTION, Jahrgang 49, Nr. 4, 08.2021, S. 757-762.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
AU - Doehn, Jan-Moritz
AU - Tabeling, Christoph
AU - Biesen, Robert
AU - Saccomanno, Jacopo
AU - Madlung, Elena
AU - Pappe, Eva
AU - Gabriel, Frieder
AU - Kurth, Florian
AU - Meisel, Christian
AU - Corman, Victor M
AU - Hanitsch, Leif G
AU - Treskatsch, Sascha
AU - Heim, Kathrin
AU - Stegemann, Miriam S
AU - Ruwwe-Glösenkamp, Christoph
AU - Müller-Redetzky, Holger C
AU - Uhrig, Alexander
AU - Somasundaram, Rajan
AU - Spies, Claudia
AU - von Bernuth, Horst
AU - Hofmann, Jörg
AU - Drosten, Christian
AU - Suttorp, Norbert
AU - Witzenrath, Martin
AU - Sander, Leif E
AU - Hübner, Ralf-Harto
N1 - © 2021. The Author(s).
PY - 2021/8
Y1 - 2021/8
N2 - Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
AB - Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
KW - Aged
KW - COVID-19/immunology
KW - Female
KW - Hospitalization
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Monocytes/immunology
KW - Retrospective Studies
KW - SARS-CoV-2/physiology
KW - Severity of Illness Index
KW - Sialic Acid Binding Ig-like Lectin 1/biosynthesis
KW - Up-Regulation
U2 - 10.1007/s15010-021-01606-9
DO - 10.1007/s15010-021-01606-9
M3 - SCORING: Journal article
C2 - 33825125
VL - 49
SP - 757
EP - 762
JO - INFECTION
JF - INFECTION
SN - 0300-8126
IS - 4
ER -