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CD147 expression lacks prognostic relevance in esophageal cancer

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CD147 expression lacks prognostic relevance in esophageal cancer. / Küsters, Natalie; Grupp, Katharina; Grass, Julia-Kristin; Bachmann, Kai; Ghadban, Tarik; Uzunoglu, Faik G; Tachezy, Michael; Perez, Daniel; Reeh, Matthias; Izbicki, Jakob R; Melling, Nathaniel.

in: J CANCER RES CLIN, Jahrgang 148, Nr. 4, 04.2022, S. 837-844.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Küsters, N, Grupp, K, Grass, J-K, Bachmann, K, Ghadban, T, Uzunoglu, FG, Tachezy, M, Perez, D, Reeh, M, Izbicki, JR & Melling, N 2022, 'CD147 expression lacks prognostic relevance in esophageal cancer', J CANCER RES CLIN, Jg. 148, Nr. 4, S. 837-844. https://doi.org/10.1007/s00432-022-03917-2

APA

Küsters, N., Grupp, K., Grass, J-K., Bachmann, K., Ghadban, T., Uzunoglu, F. G., Tachezy, M., Perez, D., Reeh, M., Izbicki, J. R., & Melling, N. (2022). CD147 expression lacks prognostic relevance in esophageal cancer. J CANCER RES CLIN, 148(4), 837-844. https://doi.org/10.1007/s00432-022-03917-2

Vancouver

Küsters N, Grupp K, Grass J-K, Bachmann K, Ghadban T, Uzunoglu FG et al. CD147 expression lacks prognostic relevance in esophageal cancer. J CANCER RES CLIN. 2022 Apr;148(4):837-844. https://doi.org/10.1007/s00432-022-03917-2

Bibtex

@article{275c2cf1ffbd45e3aeb6257069ac127d,
title = "CD147 expression lacks prognostic relevance in esophageal cancer",
abstract = "INTRODUCTION: The role of CD147 as an important indicator of tumor prognosis remains controversially discussed in literature. We focused on the prognostic significance of CD147 expression in esophageal cancer patients. While some studies report that CD147 is an unfavorable prognostic factor in esophageal squamous cell carcinoma, others showed no significant correlation. However, only one study draws attention to the significance of CD147 in esophageal adenocarcinoma, which is one of the most rapidly increasing neoplasms in the western world.METHODS: To finally clarify the impact of CD147 as a prognostic factor, especially for esophageal adenocarcinomas, we analyzed CD147 expression in a tissue microarray of 359 esophageal adenocarcinomas and 254 esophageal squamous cell cancer specimens. For the immuno-histochemical analysis, we used a primary antibody specific for CD147. Staining intensity and proportion of positive tumor cells were scored (negative, weak, moderate, strong staining). These findings were compared to normal esophageal tissue and correlated to the histopathological tumor phenotype and survival data.RESULTS: CD147 expression was detectable in weak intensities in benign esophageal tissue (85.78%) and expressed in predominately moderate to strong intensities in esophageal cancer (88.34%). Strong CD147 immunostaining was linked to increased infiltration depth (p = 0.015) and differentiation (p = 0.016) in esophageal squamous cell cancer but revealed no significant correlation with histopathology of adenocarcinoma. Moreover, CD147 intensity was unrelated to overall survival in this collective for both subtypes of esophageal cancer.CONCLUSION: Thus, our data show that CD147 has no prognostic value, neither in esophageal adenocarcinoma nor squamous cell carcinoma.",
keywords = "Adenocarcinoma/pathology, Basigin/genetics, Biomarkers, Tumor/metabolism, Carcinoma, Squamous Cell/pathology, Esophageal Neoplasms/pathology, Esophageal Squamous Cell Carcinoma, Humans, Prognosis",
author = "Natalie K{\"u}sters and Katharina Grupp and Julia-Kristin Grass and Kai Bachmann and Tarik Ghadban and Uzunoglu, {Faik G} and Michael Tachezy and Daniel Perez and Matthias Reeh and Izbicki, {Jakob R} and Nathaniel Melling",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = apr,
doi = "10.1007/s00432-022-03917-2",
language = "English",
volume = "148",
pages = "837--844",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - CD147 expression lacks prognostic relevance in esophageal cancer

AU - Küsters, Natalie

AU - Grupp, Katharina

AU - Grass, Julia-Kristin

AU - Bachmann, Kai

AU - Ghadban, Tarik

AU - Uzunoglu, Faik G

AU - Tachezy, Michael

AU - Perez, Daniel

AU - Reeh, Matthias

AU - Izbicki, Jakob R

AU - Melling, Nathaniel

N1 - © 2022. The Author(s).

PY - 2022/4

Y1 - 2022/4

N2 - INTRODUCTION: The role of CD147 as an important indicator of tumor prognosis remains controversially discussed in literature. We focused on the prognostic significance of CD147 expression in esophageal cancer patients. While some studies report that CD147 is an unfavorable prognostic factor in esophageal squamous cell carcinoma, others showed no significant correlation. However, only one study draws attention to the significance of CD147 in esophageal adenocarcinoma, which is one of the most rapidly increasing neoplasms in the western world.METHODS: To finally clarify the impact of CD147 as a prognostic factor, especially for esophageal adenocarcinomas, we analyzed CD147 expression in a tissue microarray of 359 esophageal adenocarcinomas and 254 esophageal squamous cell cancer specimens. For the immuno-histochemical analysis, we used a primary antibody specific for CD147. Staining intensity and proportion of positive tumor cells were scored (negative, weak, moderate, strong staining). These findings were compared to normal esophageal tissue and correlated to the histopathological tumor phenotype and survival data.RESULTS: CD147 expression was detectable in weak intensities in benign esophageal tissue (85.78%) and expressed in predominately moderate to strong intensities in esophageal cancer (88.34%). Strong CD147 immunostaining was linked to increased infiltration depth (p = 0.015) and differentiation (p = 0.016) in esophageal squamous cell cancer but revealed no significant correlation with histopathology of adenocarcinoma. Moreover, CD147 intensity was unrelated to overall survival in this collective for both subtypes of esophageal cancer.CONCLUSION: Thus, our data show that CD147 has no prognostic value, neither in esophageal adenocarcinoma nor squamous cell carcinoma.

AB - INTRODUCTION: The role of CD147 as an important indicator of tumor prognosis remains controversially discussed in literature. We focused on the prognostic significance of CD147 expression in esophageal cancer patients. While some studies report that CD147 is an unfavorable prognostic factor in esophageal squamous cell carcinoma, others showed no significant correlation. However, only one study draws attention to the significance of CD147 in esophageal adenocarcinoma, which is one of the most rapidly increasing neoplasms in the western world.METHODS: To finally clarify the impact of CD147 as a prognostic factor, especially for esophageal adenocarcinomas, we analyzed CD147 expression in a tissue microarray of 359 esophageal adenocarcinomas and 254 esophageal squamous cell cancer specimens. For the immuno-histochemical analysis, we used a primary antibody specific for CD147. Staining intensity and proportion of positive tumor cells were scored (negative, weak, moderate, strong staining). These findings were compared to normal esophageal tissue and correlated to the histopathological tumor phenotype and survival data.RESULTS: CD147 expression was detectable in weak intensities in benign esophageal tissue (85.78%) and expressed in predominately moderate to strong intensities in esophageal cancer (88.34%). Strong CD147 immunostaining was linked to increased infiltration depth (p = 0.015) and differentiation (p = 0.016) in esophageal squamous cell cancer but revealed no significant correlation with histopathology of adenocarcinoma. Moreover, CD147 intensity was unrelated to overall survival in this collective for both subtypes of esophageal cancer.CONCLUSION: Thus, our data show that CD147 has no prognostic value, neither in esophageal adenocarcinoma nor squamous cell carcinoma.

KW - Adenocarcinoma/pathology

KW - Basigin/genetics

KW - Biomarkers, Tumor/metabolism

KW - Carcinoma, Squamous Cell/pathology

KW - Esophageal Neoplasms/pathology

KW - Esophageal Squamous Cell Carcinoma

KW - Humans

KW - Prognosis

U2 - 10.1007/s00432-022-03917-2

DO - 10.1007/s00432-022-03917-2

M3 - SCORING: Journal article

C2 - 34997863

VL - 148

SP - 837

EP - 844

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 4

ER -