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CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease

Standard

CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease. / Koenig, Wolfgang; Khuseyinova, Natalie; März, Winfried; Fröhlich, Margit; Hoffmeister, Albrecht; Brenner, Hermann; Rothenbacher, Dietrich.

in: J AM COLL CARDIOL, Jahrgang 40, Nr. 1, 03.07.2002, S. 34-42.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Koenig, W, Khuseyinova, N, März, W, Fröhlich, M, Hoffmeister, A, Brenner, H & Rothenbacher, D 2002, 'CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease', J AM COLL CARDIOL, Jg. 40, Nr. 1, S. 34-42. https://doi.org/10.1016/s0735-1097(02)01937-x

APA

Koenig, W., Khuseyinova, N., März, W., Fröhlich, M., Hoffmeister, A., Brenner, H., & Rothenbacher, D. (2002). CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease. J AM COLL CARDIOL, 40(1), 34-42. https://doi.org/10.1016/s0735-1097(02)01937-x

Vancouver

Koenig W, Khuseyinova N, März W, Fröhlich M, Hoffmeister A, Brenner H et al. CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease. J AM COLL CARDIOL. 2002 Jul 3;40(1):34-42. https://doi.org/10.1016/s0735-1097(02)01937-x

Bibtex

@article{af3095e4b66e4840a04d165138d38dae,
title = "CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease",
abstract = "OBJECTIVES: We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation.BACKGROUND: It has been suggested that genetic variation of the CD14 receptor with increased CD14 gene expression might play a role in atherogenesis. A mechanistic link would consist in its contribution to the inflammatory response seen in this disease.METHODS: We measured levels of sCD14 (microg/ml; ELISA) in 312 patients with angiographically proven CAD and stable angina pectoris, and in 477 age- and gender-matched healthy blood donors. CD14 genotype was determined by polymerase chain reaction. In addition, seropositivity to Chlamydia pneumoniae and Helicobacter pylori, a complete lipid profile and various sensitive systemic markers of inflammation were measured.RESULTS: CD14 C(-260)-->T genotype was not independently associated with increased risk of CAD after multivariable adjustments (odds ratio [OR] 1.34; 95% confidence interval [CI] 0.84 to 2.16). However, sCD14 plasma levels were higher in subjects with TT genotype compared with those with CT or CC genotype (p = 0.005). Plasma levels were not different between cases and controls (4.2 +/- 1.3 microg/ml vs. 4.3 +/- 1.3 microg/ml, p = NS). In multivariable logistic regression, the OR for the presence of CAD was 1.11 (95% CI, 0.65 to 1.91) if the top quintile of the sCD14 distribution was compared with the bottom quintile. There was no consistent association between seropositivity to either C. pneumoniae or H. pylori, or both, and sCD14 levels and between sCD14 levels or CD14 genotype and the various markers of inflammation.CONCLUSIONS: These results do not confirm an independent relationship between CD14 genotypes or plasma levels of sCD14 and risk of stable CAD in this population.",
keywords = "Angina Pectoris/blood, Case-Control Studies, Chlamydophila Infections/blood, Chlamydophila pneumoniae/immunology, Coronary Artery Disease/blood, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Helicobacter Infections/blood, Helicobacter pylori/immunology, Humans, Lipopolysaccharide Receptors/genetics, Logistic Models, Male, Middle Aged, Polymorphism, Genetic, Risk Factors",
author = "Wolfgang Koenig and Natalie Khuseyinova and Winfried M{\"a}rz and Margit Fr{\"o}hlich and Albrecht Hoffmeister and Hermann Brenner and Dietrich Rothenbacher",
year = "2002",
month = jul,
day = "3",
doi = "10.1016/s0735-1097(02)01937-x",
language = "English",
volume = "40",
pages = "34--42",
journal = "J AM COLL CARDIOL",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "1",

}

RIS

TY - JOUR

T1 - CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease

AU - Koenig, Wolfgang

AU - Khuseyinova, Natalie

AU - März, Winfried

AU - Fröhlich, Margit

AU - Hoffmeister, Albrecht

AU - Brenner, Hermann

AU - Rothenbacher, Dietrich

PY - 2002/7/3

Y1 - 2002/7/3

N2 - OBJECTIVES: We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation.BACKGROUND: It has been suggested that genetic variation of the CD14 receptor with increased CD14 gene expression might play a role in atherogenesis. A mechanistic link would consist in its contribution to the inflammatory response seen in this disease.METHODS: We measured levels of sCD14 (microg/ml; ELISA) in 312 patients with angiographically proven CAD and stable angina pectoris, and in 477 age- and gender-matched healthy blood donors. CD14 genotype was determined by polymerase chain reaction. In addition, seropositivity to Chlamydia pneumoniae and Helicobacter pylori, a complete lipid profile and various sensitive systemic markers of inflammation were measured.RESULTS: CD14 C(-260)-->T genotype was not independently associated with increased risk of CAD after multivariable adjustments (odds ratio [OR] 1.34; 95% confidence interval [CI] 0.84 to 2.16). However, sCD14 plasma levels were higher in subjects with TT genotype compared with those with CT or CC genotype (p = 0.005). Plasma levels were not different between cases and controls (4.2 +/- 1.3 microg/ml vs. 4.3 +/- 1.3 microg/ml, p = NS). In multivariable logistic regression, the OR for the presence of CAD was 1.11 (95% CI, 0.65 to 1.91) if the top quintile of the sCD14 distribution was compared with the bottom quintile. There was no consistent association between seropositivity to either C. pneumoniae or H. pylori, or both, and sCD14 levels and between sCD14 levels or CD14 genotype and the various markers of inflammation.CONCLUSIONS: These results do not confirm an independent relationship between CD14 genotypes or plasma levels of sCD14 and risk of stable CAD in this population.

AB - OBJECTIVES: We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation.BACKGROUND: It has been suggested that genetic variation of the CD14 receptor with increased CD14 gene expression might play a role in atherogenesis. A mechanistic link would consist in its contribution to the inflammatory response seen in this disease.METHODS: We measured levels of sCD14 (microg/ml; ELISA) in 312 patients with angiographically proven CAD and stable angina pectoris, and in 477 age- and gender-matched healthy blood donors. CD14 genotype was determined by polymerase chain reaction. In addition, seropositivity to Chlamydia pneumoniae and Helicobacter pylori, a complete lipid profile and various sensitive systemic markers of inflammation were measured.RESULTS: CD14 C(-260)-->T genotype was not independently associated with increased risk of CAD after multivariable adjustments (odds ratio [OR] 1.34; 95% confidence interval [CI] 0.84 to 2.16). However, sCD14 plasma levels were higher in subjects with TT genotype compared with those with CT or CC genotype (p = 0.005). Plasma levels were not different between cases and controls (4.2 +/- 1.3 microg/ml vs. 4.3 +/- 1.3 microg/ml, p = NS). In multivariable logistic regression, the OR for the presence of CAD was 1.11 (95% CI, 0.65 to 1.91) if the top quintile of the sCD14 distribution was compared with the bottom quintile. There was no consistent association between seropositivity to either C. pneumoniae or H. pylori, or both, and sCD14 levels and between sCD14 levels or CD14 genotype and the various markers of inflammation.CONCLUSIONS: These results do not confirm an independent relationship between CD14 genotypes or plasma levels of sCD14 and risk of stable CAD in this population.

KW - Angina Pectoris/blood

KW - Case-Control Studies

KW - Chlamydophila Infections/blood

KW - Chlamydophila pneumoniae/immunology

KW - Coronary Artery Disease/blood

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Genotype

KW - Helicobacter Infections/blood

KW - Helicobacter pylori/immunology

KW - Humans

KW - Lipopolysaccharide Receptors/genetics

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Risk Factors

U2 - 10.1016/s0735-1097(02)01937-x

DO - 10.1016/s0735-1097(02)01937-x

M3 - SCORING: Journal article

C2 - 12103253

VL - 40

SP - 34

EP - 42

JO - J AM COLL CARDIOL

JF - J AM COLL CARDIOL

SN - 0735-1097

IS - 1

ER -