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Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond

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Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. / Benz, Peter M; Frömel, Timo; Laban, Hebatullah; Zink, Joana; Ulrich, Lea; Groneberg, Dieter; Boon, Reinier A; Poley, Philip; Renne, Thomas; de Wit, Cor; Fleming, Ingrid.

in: CELLS-BASEL, Jahrgang 12, Nr. 13, 1740, 28.06.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Benz, PM, Frömel, T, Laban, H, Zink, J, Ulrich, L, Groneberg, D, Boon, RA, Poley, P, Renne, T, de Wit, C & Fleming, I 2023, 'Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond', CELLS-BASEL, Jg. 12, Nr. 13, 1740. https://doi.org/10.3390/cells12131740

APA

Benz, P. M., Frömel, T., Laban, H., Zink, J., Ulrich, L., Groneberg, D., Boon, R. A., Poley, P., Renne, T., de Wit, C., & Fleming, I. (2023). Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. CELLS-BASEL, 12(13), [1740]. https://doi.org/10.3390/cells12131740

Vancouver

Benz PM, Frömel T, Laban H, Zink J, Ulrich L, Groneberg D et al. Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. CELLS-BASEL. 2023 Jun 28;12(13). 1740. https://doi.org/10.3390/cells12131740

Bibtex

@article{299b43639b1f4f499d6b71881e92fa51,
title = "Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond",
abstract = "Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms.",
author = "Benz, {Peter M} and Timo Fr{\"o}mel and Hebatullah Laban and Joana Zink and Lea Ulrich and Dieter Groneberg and Boon, {Reinier A} and Philip Poley and Thomas Renne and {de Wit}, Cor and Ingrid Fleming",
year = "2023",
month = jun,
day = "28",
doi = "10.3390/cells12131740",
language = "English",
volume = "12",
journal = "CELLS-BASEL",
issn = "2073-4409",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "13",

}

RIS

TY - JOUR

T1 - Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond

AU - Benz, Peter M

AU - Frömel, Timo

AU - Laban, Hebatullah

AU - Zink, Joana

AU - Ulrich, Lea

AU - Groneberg, Dieter

AU - Boon, Reinier A

AU - Poley, Philip

AU - Renne, Thomas

AU - de Wit, Cor

AU - Fleming, Ingrid

PY - 2023/6/28

Y1 - 2023/6/28

N2 - Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms.

AB - Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms.

U2 - 10.3390/cells12131740

DO - 10.3390/cells12131740

M3 - SCORING: Review article

C2 - 37443774

VL - 12

JO - CELLS-BASEL

JF - CELLS-BASEL

SN - 2073-4409

IS - 13

M1 - 1740

ER -