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Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation

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Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation. / Sinn, Martin; Petersen, Johannes; Lenz, Alexander; von Stumm, Maria; Sequeira Groß, Tatiana Maria; Huber, Lukas; Reichenspurner, Hermann; Adam, Gerhard; Lund, Gunnar; Bannas, Peter; Girdauskas, Evaldas.

in: FRONT CARDIOVASC MED, Jahrgang 10, 06.2023, S. 1155787.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sinn, M, Petersen, J, Lenz, A, von Stumm, M, Sequeira Groß, TM, Huber, L, Reichenspurner, H, Adam, G, Lund, G, Bannas, P & Girdauskas, E 2023, 'Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation', FRONT CARDIOVASC MED, Jg. 10, S. 1155787. https://doi.org/10.3389/fcvm.2023.1155787

APA

Sinn, M., Petersen, J., Lenz, A., von Stumm, M., Sequeira Groß, T. M., Huber, L., Reichenspurner, H., Adam, G., Lund, G., Bannas, P., & Girdauskas, E. (2023). Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation. FRONT CARDIOVASC MED, 10, 1155787. https://doi.org/10.3389/fcvm.2023.1155787

Vancouver

Sinn M, Petersen J, Lenz A, von Stumm M, Sequeira Groß TM, Huber L et al. Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation. FRONT CARDIOVASC MED. 2023 Jun;10:1155787. https://doi.org/10.3389/fcvm.2023.1155787

Bibtex

@article{0b1943f8db954b2f8e861a8db72beeaf,
title = "Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation",
abstract = "BACKGROUND: To assess whether cardiac T1 mapping for detecting myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.METHODS: 1.5 Tesla cardiac magnetic resonance imaging was performed in 40 consecutive aortic regurgitation patients before aortic valve surgery. Native and post-contrast T1 mapping was performed using a modified Look-Locker inversion-recovery sequence. Serial echocardiography was performed at baseline and 8 ± 5 days after aortic valve surgery to quantify LV dysfunction. Receiver operating characteristic analysis was performed to determine the diagnostic accuracy of native T1 mapping and extracellular volume for predicting postoperative LV ejection fraction decrease >-10% after aortic valve surgery.RESULTS: Native T1 was significantly increased in patients with a postoperatively decreased LVEF (n = 15) vs. patients with a preserved postoperative LV ejection fraction (n = 25) (i.e., 1,071 ± 67 ms vs. 1,019 ± 33 ms, p = .001). Extracellular volume was not significantly different between patients with preserved vs. decreased postoperative LV ejection fraction. With a cutoff-of value of 1,053 ms, native T1 yielded an area under the curve (AUC) of .820 (95% CI: .683-.958) for differentiating between patients with preserved vs. reduced LV ejection fraction with 70% sensitivity and 84% specificity.CONCLUSION: Increased preoperative native T1 is associated with a significantly higher risk of systolic LV dysfunction early after aortic valve surgery in aortic regurgitation patients. Native T1 could be a promising tool to optimize the timing of aortic valve surgery in patients with aortic regurgitation to prevent early postoperative LV dysfunction.",
author = "Martin Sinn and Johannes Petersen and Alexander Lenz and {von Stumm}, Maria and {Sequeira Gro{\ss}}, {Tatiana Maria} and Lukas Huber and Hermann Reichenspurner and Gerhard Adam and Gunnar Lund and Peter Bannas and Evaldas Girdauskas",
note = "{\textcopyright} 2023 Sinn, Petersen, Lenz, von Stumm, Sequeira Gro{\ss}, Huber, Reichenspurner, Adam, Lund, Bannas and Girdauskas.",
year = "2023",
month = jun,
doi = "10.3389/fcvm.2023.1155787",
language = "English",
volume = "10",
pages = "1155787",
journal = "FRONT CARDIOVASC MED",
issn = "2297-055X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation

AU - Sinn, Martin

AU - Petersen, Johannes

AU - Lenz, Alexander

AU - von Stumm, Maria

AU - Sequeira Groß, Tatiana Maria

AU - Huber, Lukas

AU - Reichenspurner, Hermann

AU - Adam, Gerhard

AU - Lund, Gunnar

AU - Bannas, Peter

AU - Girdauskas, Evaldas

N1 - © 2023 Sinn, Petersen, Lenz, von Stumm, Sequeira Groß, Huber, Reichenspurner, Adam, Lund, Bannas and Girdauskas.

PY - 2023/6

Y1 - 2023/6

N2 - BACKGROUND: To assess whether cardiac T1 mapping for detecting myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.METHODS: 1.5 Tesla cardiac magnetic resonance imaging was performed in 40 consecutive aortic regurgitation patients before aortic valve surgery. Native and post-contrast T1 mapping was performed using a modified Look-Locker inversion-recovery sequence. Serial echocardiography was performed at baseline and 8 ± 5 days after aortic valve surgery to quantify LV dysfunction. Receiver operating characteristic analysis was performed to determine the diagnostic accuracy of native T1 mapping and extracellular volume for predicting postoperative LV ejection fraction decrease >-10% after aortic valve surgery.RESULTS: Native T1 was significantly increased in patients with a postoperatively decreased LVEF (n = 15) vs. patients with a preserved postoperative LV ejection fraction (n = 25) (i.e., 1,071 ± 67 ms vs. 1,019 ± 33 ms, p = .001). Extracellular volume was not significantly different between patients with preserved vs. decreased postoperative LV ejection fraction. With a cutoff-of value of 1,053 ms, native T1 yielded an area under the curve (AUC) of .820 (95% CI: .683-.958) for differentiating between patients with preserved vs. reduced LV ejection fraction with 70% sensitivity and 84% specificity.CONCLUSION: Increased preoperative native T1 is associated with a significantly higher risk of systolic LV dysfunction early after aortic valve surgery in aortic regurgitation patients. Native T1 could be a promising tool to optimize the timing of aortic valve surgery in patients with aortic regurgitation to prevent early postoperative LV dysfunction.

AB - BACKGROUND: To assess whether cardiac T1 mapping for detecting myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.METHODS: 1.5 Tesla cardiac magnetic resonance imaging was performed in 40 consecutive aortic regurgitation patients before aortic valve surgery. Native and post-contrast T1 mapping was performed using a modified Look-Locker inversion-recovery sequence. Serial echocardiography was performed at baseline and 8 ± 5 days after aortic valve surgery to quantify LV dysfunction. Receiver operating characteristic analysis was performed to determine the diagnostic accuracy of native T1 mapping and extracellular volume for predicting postoperative LV ejection fraction decrease >-10% after aortic valve surgery.RESULTS: Native T1 was significantly increased in patients with a postoperatively decreased LVEF (n = 15) vs. patients with a preserved postoperative LV ejection fraction (n = 25) (i.e., 1,071 ± 67 ms vs. 1,019 ± 33 ms, p = .001). Extracellular volume was not significantly different between patients with preserved vs. decreased postoperative LV ejection fraction. With a cutoff-of value of 1,053 ms, native T1 yielded an area under the curve (AUC) of .820 (95% CI: .683-.958) for differentiating between patients with preserved vs. reduced LV ejection fraction with 70% sensitivity and 84% specificity.CONCLUSION: Increased preoperative native T1 is associated with a significantly higher risk of systolic LV dysfunction early after aortic valve surgery in aortic regurgitation patients. Native T1 could be a promising tool to optimize the timing of aortic valve surgery in patients with aortic regurgitation to prevent early postoperative LV dysfunction.

U2 - 10.3389/fcvm.2023.1155787

DO - 10.3389/fcvm.2023.1155787

M3 - SCORING: Journal article

C2 - 37424901

VL - 10

SP - 1155787

JO - FRONT CARDIOVASC MED

JF - FRONT CARDIOVASC MED

SN - 2297-055X

ER -