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Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

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Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs. / Abawi, Dawud; Faragli, Alessandro; Schwarzl, Michael; Manninger, Martin; Zweiker, David; Kresoja, Karl-Patrik; Verderber, Jochen; Zirngast, Birgit; Maechler, Heinrich; Steendijk, Paul; Pieske, Burkert; Post, Heiner; Alogna, Alessio.

in: BMC CARDIOVASC DISOR, Jahrgang 19, Nr. 1, 15.10.2019, S. 217.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Abawi, D, Faragli, A, Schwarzl, M, Manninger, M, Zweiker, D, Kresoja, K-P, Verderber, J, Zirngast, B, Maechler, H, Steendijk, P, Pieske, B, Post, H & Alogna, A 2019, 'Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs', BMC CARDIOVASC DISOR, Jg. 19, Nr. 1, S. 217. https://doi.org/10.1186/s12872-019-1212-2

APA

Abawi, D., Faragli, A., Schwarzl, M., Manninger, M., Zweiker, D., Kresoja, K-P., Verderber, J., Zirngast, B., Maechler, H., Steendijk, P., Pieske, B., Post, H., & Alogna, A. (2019). Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs. BMC CARDIOVASC DISOR, 19(1), 217. https://doi.org/10.1186/s12872-019-1212-2

Vancouver

Abawi D, Faragli A, Schwarzl M, Manninger M, Zweiker D, Kresoja K-P et al. Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs. BMC CARDIOVASC DISOR. 2019 Okt 15;19(1):217. https://doi.org/10.1186/s12872-019-1212-2

Bibtex

@article{abcd372103644558a1f75a7a2807ff51,
title = "Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs",
abstract = "BACKGROUND: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 under various inotropic states.METHODS: We retrospectively analysed data obtained from experimental studies of the hemodynamic impact of mild hypothermia and hyperthermia on acute heart failure. Fifty-nine anaesthetized and mechanically ventilated closed-chest Landrace pigs (68 ± 1 kg) were instrumented with Swan-Ganz and LV pressure-volume catheters. Data were obtained at body temperatures of 33.0 °C, 38.0 °C and 40.5 °C; before and after: resuscitation, myocardial infarction, endotoxemia, sevoflurane-induced myocardial depression and beta-adrenergic stimulation. We plotted LVSW min- 1 against CPO by linear regression analysis, as well as against the following classical indices of LV function and work: LV ejection fraction (LV EF), rate-pressure product (RPP), triple product (TP), LV maximum pressure (LVPmax) and maximal rate of rise of LVP (LV dP/dtmax).RESULTS: CPO showed the best correlation with LV SW min- 1 (r2 = 0.89; p < 0.05) while LV EF did not correlate at all (r2 = 0.01; p = 0.259). Further parameters correlated moderately with LV SW min- 1 (LVPmax r2 = 0.47, RPP r2 = 0.67; and TP r2 = 0.54). LV dP/dtmax correlated worst with LV SW min- 1 (r2 = 0.28).CONCLUSION: CPO reflects external cardiac work over a wide range of inotropic states. These data further support the use of CPO to monitor inotropic interventions in the ICU.",
keywords = "Adrenergic beta-Agonists/pharmacology, Animals, Disease Models, Animal, Dobutamine/pharmacology, Endotoxemia/physiopathology, Heart Failure/diagnosis, Hyperthermia, Induced, Hypothermia, Induced, Myocardial Infarction/diagnosis, Resuscitation, Sevoflurane/pharmacology, Stroke Volume/drug effects, Sus scrofa, Time Factors, Ventricular Fibrillation/diagnosis, Ventricular Function, Left/drug effects, Ventricular Pressure/drug effects",
author = "Dawud Abawi and Alessandro Faragli and Michael Schwarzl and Martin Manninger and David Zweiker and Karl-Patrik Kresoja and Jochen Verderber and Birgit Zirngast and Heinrich Maechler and Paul Steendijk and Burkert Pieske and Heiner Post and Alessio Alogna",
year = "2019",
month = oct,
day = "15",
doi = "10.1186/s12872-019-1212-2",
language = "English",
volume = "19",
pages = "217",
journal = "BMC CARDIOVASC DISOR",
issn = "1471-2261",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

AU - Abawi, Dawud

AU - Faragli, Alessandro

AU - Schwarzl, Michael

AU - Manninger, Martin

AU - Zweiker, David

AU - Kresoja, Karl-Patrik

AU - Verderber, Jochen

AU - Zirngast, Birgit

AU - Maechler, Heinrich

AU - Steendijk, Paul

AU - Pieske, Burkert

AU - Post, Heiner

AU - Alogna, Alessio

PY - 2019/10/15

Y1 - 2019/10/15

N2 - BACKGROUND: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 under various inotropic states.METHODS: We retrospectively analysed data obtained from experimental studies of the hemodynamic impact of mild hypothermia and hyperthermia on acute heart failure. Fifty-nine anaesthetized and mechanically ventilated closed-chest Landrace pigs (68 ± 1 kg) were instrumented with Swan-Ganz and LV pressure-volume catheters. Data were obtained at body temperatures of 33.0 °C, 38.0 °C and 40.5 °C; before and after: resuscitation, myocardial infarction, endotoxemia, sevoflurane-induced myocardial depression and beta-adrenergic stimulation. We plotted LVSW min- 1 against CPO by linear regression analysis, as well as against the following classical indices of LV function and work: LV ejection fraction (LV EF), rate-pressure product (RPP), triple product (TP), LV maximum pressure (LVPmax) and maximal rate of rise of LVP (LV dP/dtmax).RESULTS: CPO showed the best correlation with LV SW min- 1 (r2 = 0.89; p < 0.05) while LV EF did not correlate at all (r2 = 0.01; p = 0.259). Further parameters correlated moderately with LV SW min- 1 (LVPmax r2 = 0.47, RPP r2 = 0.67; and TP r2 = 0.54). LV dP/dtmax correlated worst with LV SW min- 1 (r2 = 0.28).CONCLUSION: CPO reflects external cardiac work over a wide range of inotropic states. These data further support the use of CPO to monitor inotropic interventions in the ICU.

AB - BACKGROUND: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 under various inotropic states.METHODS: We retrospectively analysed data obtained from experimental studies of the hemodynamic impact of mild hypothermia and hyperthermia on acute heart failure. Fifty-nine anaesthetized and mechanically ventilated closed-chest Landrace pigs (68 ± 1 kg) were instrumented with Swan-Ganz and LV pressure-volume catheters. Data were obtained at body temperatures of 33.0 °C, 38.0 °C and 40.5 °C; before and after: resuscitation, myocardial infarction, endotoxemia, sevoflurane-induced myocardial depression and beta-adrenergic stimulation. We plotted LVSW min- 1 against CPO by linear regression analysis, as well as against the following classical indices of LV function and work: LV ejection fraction (LV EF), rate-pressure product (RPP), triple product (TP), LV maximum pressure (LVPmax) and maximal rate of rise of LVP (LV dP/dtmax).RESULTS: CPO showed the best correlation with LV SW min- 1 (r2 = 0.89; p < 0.05) while LV EF did not correlate at all (r2 = 0.01; p = 0.259). Further parameters correlated moderately with LV SW min- 1 (LVPmax r2 = 0.47, RPP r2 = 0.67; and TP r2 = 0.54). LV dP/dtmax correlated worst with LV SW min- 1 (r2 = 0.28).CONCLUSION: CPO reflects external cardiac work over a wide range of inotropic states. These data further support the use of CPO to monitor inotropic interventions in the ICU.

KW - Adrenergic beta-Agonists/pharmacology

KW - Animals

KW - Disease Models, Animal

KW - Dobutamine/pharmacology

KW - Endotoxemia/physiopathology

KW - Heart Failure/diagnosis

KW - Hyperthermia, Induced

KW - Hypothermia, Induced

KW - Myocardial Infarction/diagnosis

KW - Resuscitation

KW - Sevoflurane/pharmacology

KW - Stroke Volume/drug effects

KW - Sus scrofa

KW - Time Factors

KW - Ventricular Fibrillation/diagnosis

KW - Ventricular Function, Left/drug effects

KW - Ventricular Pressure/drug effects

U2 - 10.1186/s12872-019-1212-2

DO - 10.1186/s12872-019-1212-2

M3 - SCORING: Journal article

C2 - 31615415

VL - 19

SP - 217

JO - BMC CARDIOVASC DISOR

JF - BMC CARDIOVASC DISOR

SN - 1471-2261

IS - 1

ER -