Cardiac mechanics in heart transplant recipients with and without transplant vasculopathy
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Cardiac mechanics in heart transplant recipients with and without transplant vasculopathy. / Zengin, Elvin; Westermann, Dirk; Radunski, Ulf; Ojeda, Francisco; Muellerleile, Kai; Reichenspurner, Hermann; Blankenberg, Stefan; Sinning, Christoph.
in: INT J CARDIOVAS IMAG, Jahrgang 31, Nr. 4, 04.2015, S. 795-803.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cardiac mechanics in heart transplant recipients with and without transplant vasculopathy
AU - Zengin, Elvin
AU - Westermann, Dirk
AU - Radunski, Ulf
AU - Ojeda, Francisco
AU - Muellerleile, Kai
AU - Reichenspurner, Hermann
AU - Blankenberg, Stefan
AU - Sinning, Christoph
PY - 2015/4
Y1 - 2015/4
N2 - Evaluation of cardiac mechanics in heart transplant recipients (HTR) is of paramount importance. Assessment of strain through echocardiography is suited to describe cardiac function and might allow characterizing patients with and without transplant vasculopathy (TVP) a risk factor of impaired organ function and rejection. For this study 41 HTR immediately after and 1-3 years after transplantation were examined in a retrospective approach with 2-dimensional speckle tracking echocardiography to assess longitudinal, radial and circumferential strain and strain rate. The cohort consists of 33 men and 8 women with a median age of 54 years (1st, 3rd; 45.7, 65.3) with seven cases diagnosed with TVP during follow-up, as diagnosed by coronary angiography. The overall cohort showed an improvement of global longitudinal strain from baseline to 1 and 3 years with -14.2% (-16.9, -12.3%) to -16.1% (-17.5, -14.3%) and -16.7% (-18, -13.7%), p = 0.036. For patients developing TVP, global longitudinal strain was not different from baseline up to the maximum of 3 years -16.6% (-16.7-13.8%) to -16.4% (-17.3, -14.7%) and -17.6% (-18.7, -16.9%) with p = 0.21. Radial strain and torsion showed a trend to decrease after transplantation with time. Circumferential strain remained stable in HTR but decreased in subjects with TVP. Longitudinal Strain and strain rate showed no relevant changes in HTR with and without TVP. Radial strain and torsion declined in HTR as well as TVP patients with time. Speckle tracking imaging is useful to assess organ function in HTR, however coronary angiography is still needed to rule out TVP.
AB - Evaluation of cardiac mechanics in heart transplant recipients (HTR) is of paramount importance. Assessment of strain through echocardiography is suited to describe cardiac function and might allow characterizing patients with and without transplant vasculopathy (TVP) a risk factor of impaired organ function and rejection. For this study 41 HTR immediately after and 1-3 years after transplantation were examined in a retrospective approach with 2-dimensional speckle tracking echocardiography to assess longitudinal, radial and circumferential strain and strain rate. The cohort consists of 33 men and 8 women with a median age of 54 years (1st, 3rd; 45.7, 65.3) with seven cases diagnosed with TVP during follow-up, as diagnosed by coronary angiography. The overall cohort showed an improvement of global longitudinal strain from baseline to 1 and 3 years with -14.2% (-16.9, -12.3%) to -16.1% (-17.5, -14.3%) and -16.7% (-18, -13.7%), p = 0.036. For patients developing TVP, global longitudinal strain was not different from baseline up to the maximum of 3 years -16.6% (-16.7-13.8%) to -16.4% (-17.3, -14.7%) and -17.6% (-18.7, -16.9%) with p = 0.21. Radial strain and torsion showed a trend to decrease after transplantation with time. Circumferential strain remained stable in HTR but decreased in subjects with TVP. Longitudinal Strain and strain rate showed no relevant changes in HTR with and without TVP. Radial strain and torsion declined in HTR as well as TVP patients with time. Speckle tracking imaging is useful to assess organ function in HTR, however coronary angiography is still needed to rule out TVP.
KW - Aged
KW - Biomechanical Phenomena
KW - Coronary Artery Disease/diagnosis
KW - Female
KW - Heart Transplantation/adverse effects
KW - Humans
KW - Immunosuppressive Agents/adverse effects
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Myocardial Contraction/drug effects
KW - Predictive Value of Tests
KW - Retrospective Studies
KW - Stress, Mechanical
KW - Stroke Volume
KW - Time Factors
KW - Torsion, Mechanical
KW - Treatment Outcome
KW - Ventricular Function/drug effects
U2 - 10.1007/s10554-015-0625-y
DO - 10.1007/s10554-015-0625-y
M3 - SCORING: Journal article
C2 - 25697723
VL - 31
SP - 795
EP - 803
JO - INT J CARDIOVAS IMAG
JF - INT J CARDIOVAS IMAG
SN - 1569-5794
IS - 4
ER -
