PortalPublikationenCarbonic anhydrase IX correlates with survival and is a pote...

Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma

Standard

Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma. / Ameis, Helen M; Drenckhan, Astrid; Freytag, Morton; Izbicki, Jakob R; Supuran, Claudiu T; Reinshagen, Konrad; Holland-Cunz, Stefan; Gros, Stephanie J.

in: J ENZYM INHIB MED CH, Jahrgang 31, Nr. 3, 2016, S. 404-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ameis, HM, Drenckhan, A, Freytag, M, Izbicki, JR, Supuran, CT, Reinshagen, K, Holland-Cunz, S & Gros, SJ 2016, 'Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma', J ENZYM INHIB MED CH, Jg. 31, Nr. 3, S. 404-9. https://doi.org/10.3109/14756366.2015.1029471

APA

Ameis, H. M., Drenckhan, A., Freytag, M., Izbicki, J. R., Supuran, C. T., Reinshagen, K., Holland-Cunz, S., & Gros, S. J. (2016). Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma. J ENZYM INHIB MED CH, 31(3), 404-9. https://doi.org/10.3109/14756366.2015.1029471

Vancouver

Ameis HM, Drenckhan A, Freytag M, Izbicki JR, Supuran CT, Reinshagen K et al. Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma. J ENZYM INHIB MED CH. 2016;31(3):404-9. https://doi.org/10.3109/14756366.2015.1029471

Bibtex

@article{61bf9d8afc0149d3b2c8c49f472aca27,
title = "Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma",
abstract = "Carbonic anhydrase IX (CAIX) is involved in pathological processes including tumorgenicity, metastases and poor survival in solid tumors. Twenty-two neuroblastoma samples of patients who were surgically treated at the University Medical Center Hamburg-Eppendorf were evaluated immunohistochemically for expression of CAIX. Results were correlated with clinical parameters and outcome. Neuroblastoma Kelly and SH-EP-Tet-21/N cells were examined for CAIX expression and inhibited with specific inhibitors, FC5-207A and FC8-325A. 32% of neuroblastoma tumors expressed CAIX. This was significantly associated with poorer survival. Kelly and SH-EP-Tet-21/N cells showed a major increase of CAIX RNA under hypoxic conditions. Proliferation of Kelly cells was significantly decreased by CAIX inhibitors, FC5-207A and FC8-325A, while proliferation of SH-EP-Tet-21/N cells was only significantly affected by FC8-325A. CAIX is a potent biomarker that predicts survival in neuroblastoma patients. CAIX-targeted therapy in neuroblastoma cell lines is highly effective and strengthens the potential of CAIX as a clinical therapeutic target in a selected patient collective.",
keywords = "Antigens, Neoplasm, Antineoplastic Agents, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Cell Proliferation, Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Infant, Infant, Newborn, Molecular Structure, Neuroblastoma, Structure-Activity Relationship, Survival Analysis, Tumor Cells, Cultured, Journal Article",
author = "Ameis, {Helen M} and Astrid Drenckhan and Morton Freytag and Izbicki, {Jakob R} and Supuran, {Claudiu T} and Konrad Reinshagen and Stefan Holland-Cunz and Gros, {Stephanie J}",
year = "2016",
doi = "10.3109/14756366.2015.1029471",
language = "English",
volume = "31",
pages = "404--9",
journal = "J ENZYM INHIB MED CH",
issn = "1475-6366",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma

AU - Ameis, Helen M

AU - Drenckhan, Astrid

AU - Freytag, Morton

AU - Izbicki, Jakob R

AU - Supuran, Claudiu T

AU - Reinshagen, Konrad

AU - Holland-Cunz, Stefan

AU - Gros, Stephanie J

PY - 2016

Y1 - 2016

N2 - Carbonic anhydrase IX (CAIX) is involved in pathological processes including tumorgenicity, metastases and poor survival in solid tumors. Twenty-two neuroblastoma samples of patients who were surgically treated at the University Medical Center Hamburg-Eppendorf were evaluated immunohistochemically for expression of CAIX. Results were correlated with clinical parameters and outcome. Neuroblastoma Kelly and SH-EP-Tet-21/N cells were examined for CAIX expression and inhibited with specific inhibitors, FC5-207A and FC8-325A. 32% of neuroblastoma tumors expressed CAIX. This was significantly associated with poorer survival. Kelly and SH-EP-Tet-21/N cells showed a major increase of CAIX RNA under hypoxic conditions. Proliferation of Kelly cells was significantly decreased by CAIX inhibitors, FC5-207A and FC8-325A, while proliferation of SH-EP-Tet-21/N cells was only significantly affected by FC8-325A. CAIX is a potent biomarker that predicts survival in neuroblastoma patients. CAIX-targeted therapy in neuroblastoma cell lines is highly effective and strengthens the potential of CAIX as a clinical therapeutic target in a selected patient collective.

AB - Carbonic anhydrase IX (CAIX) is involved in pathological processes including tumorgenicity, metastases and poor survival in solid tumors. Twenty-two neuroblastoma samples of patients who were surgically treated at the University Medical Center Hamburg-Eppendorf were evaluated immunohistochemically for expression of CAIX. Results were correlated with clinical parameters and outcome. Neuroblastoma Kelly and SH-EP-Tet-21/N cells were examined for CAIX expression and inhibited with specific inhibitors, FC5-207A and FC8-325A. 32% of neuroblastoma tumors expressed CAIX. This was significantly associated with poorer survival. Kelly and SH-EP-Tet-21/N cells showed a major increase of CAIX RNA under hypoxic conditions. Proliferation of Kelly cells was significantly decreased by CAIX inhibitors, FC5-207A and FC8-325A, while proliferation of SH-EP-Tet-21/N cells was only significantly affected by FC8-325A. CAIX is a potent biomarker that predicts survival in neuroblastoma patients. CAIX-targeted therapy in neuroblastoma cell lines is highly effective and strengthens the potential of CAIX as a clinical therapeutic target in a selected patient collective.

KW - Antigens, Neoplasm

KW - Antineoplastic Agents

KW - Carbonic Anhydrase Inhibitors

KW - Carbonic Anhydrases

KW - Cell Proliferation

KW - Child

KW - Child, Preschool

KW - Dose-Response Relationship, Drug

KW - Drug Screening Assays, Antitumor

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Molecular Structure

KW - Neuroblastoma

KW - Structure-Activity Relationship

KW - Survival Analysis

KW - Tumor Cells, Cultured

KW - Journal Article

U2 - 10.3109/14756366.2015.1029471

DO - 10.3109/14756366.2015.1029471

M3 - SCORING: Journal article

C2 - 25884234

VL - 31

SP - 404

EP - 409

JO - J ENZYM INHIB MED CH

JF - J ENZYM INHIB MED CH

SN - 1475-6366

IS - 3

ER -