Capturing adenylyl cyclases as potential drug targets.
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Capturing adenylyl cyclases as potential drug targets. / Pierre, Sandra; Eschenhagen, Thomas; Geisslinger, Gerd; Scholich, Klaus.
in: NAT REV DRUG DISCOV, Jahrgang 8, Nr. 4, 4, 2009, S. 321-335.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Capturing adenylyl cyclases as potential drug targets.
AU - Pierre, Sandra
AU - Eschenhagen, Thomas
AU - Geisslinger, Gerd
AU - Scholich, Klaus
PY - 2009
Y1 - 2009
N2 - Cyclic AMP (cAMP) is an important intracellular signalling mediator. It is generated in mammals by nine membrane-bound and one soluble adenylyl cyclases (ACs), each with distinct regulation and expression patterns. Although many drugs inhibit or stimulate AC activity through the respective upstream G-protein coupled receptors (for example, opioid or beta-adrenergic receptors), ACs themselves have not been major drug targets. Over the past decade studies on the physiological functions of the different mammalian AC isoforms as well as advances in the development of isoform-selective AC inhibitors and activators suggest that ACs could be useful drug targets. Here we discuss the therapeutic potential of isoform-selective compounds in various clinical settings, including neuropathic pain, neurodegenerative disorders, congestive heart failure, asthma and male contraception.
AB - Cyclic AMP (cAMP) is an important intracellular signalling mediator. It is generated in mammals by nine membrane-bound and one soluble adenylyl cyclases (ACs), each with distinct regulation and expression patterns. Although many drugs inhibit or stimulate AC activity through the respective upstream G-protein coupled receptors (for example, opioid or beta-adrenergic receptors), ACs themselves have not been major drug targets. Over the past decade studies on the physiological functions of the different mammalian AC isoforms as well as advances in the development of isoform-selective AC inhibitors and activators suggest that ACs could be useful drug targets. Here we discuss the therapeutic potential of isoform-selective compounds in various clinical settings, including neuropathic pain, neurodegenerative disorders, congestive heart failure, asthma and male contraception.
M3 - SCORING: Zeitschriftenaufsatz
VL - 8
SP - 321
EP - 335
JO - NAT REV DRUG DISCOV
JF - NAT REV DRUG DISCOV
SN - 1474-1776
IS - 4
M1 - 4
ER -
