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Candidalysin is a fungal peptide toxin critical for mucosal infection

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Candidalysin is a fungal peptide toxin critical for mucosal infection. / Moyes, David L; Wilson, Duncan; Richardson, Jonathan P; Mogavero, Selene; Tang, Shirley X; Wernecke, Julia; Höfs, Sarah; Gratacap, Remi L; Robbins, Jon; Runglall, Manohursingh; Murciano, Celia; Blagojevic, Mariana; Thavaraj, Selvam; Förster, Toni M; Hebecker, Betty; Kasper, Lydia; Vizcay, Gema; Iancu, Simona I; Kichik, Nessim; Häder, Antje; Kurzai, Oliver; Luo, Ting; Krüger, Thomas; Kniemeyer, Olaf; Cota, Ernesto; Bader, Oliver; Wheeler, Robert T; Gutsmann, Thomas; Hube, Bernhard; Naglik, Julian R.

in: NATURE, Jahrgang 532, Nr. 7597, 07.04.2016, S. 64-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Moyes, DL, Wilson, D, Richardson, JP, Mogavero, S, Tang, SX, Wernecke, J, Höfs, S, Gratacap, RL, Robbins, J, Runglall, M, Murciano, C, Blagojevic, M, Thavaraj, S, Förster, TM, Hebecker, B, Kasper, L, Vizcay, G, Iancu, SI, Kichik, N, Häder, A, Kurzai, O, Luo, T, Krüger, T, Kniemeyer, O, Cota, E, Bader, O, Wheeler, RT, Gutsmann, T, Hube, B & Naglik, JR 2016, 'Candidalysin is a fungal peptide toxin critical for mucosal infection', NATURE, Jg. 532, Nr. 7597, S. 64-8. https://doi.org/10.1038/nature17625

APA

Moyes, D. L., Wilson, D., Richardson, J. P., Mogavero, S., Tang, S. X., Wernecke, J., Höfs, S., Gratacap, R. L., Robbins, J., Runglall, M., Murciano, C., Blagojevic, M., Thavaraj, S., Förster, T. M., Hebecker, B., Kasper, L., Vizcay, G., Iancu, S. I., Kichik, N., ... Naglik, J. R. (2016). Candidalysin is a fungal peptide toxin critical for mucosal infection. NATURE, 532(7597), 64-8. https://doi.org/10.1038/nature17625

Vancouver

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J et al. Candidalysin is a fungal peptide toxin critical for mucosal infection. NATURE. 2016 Apr 7;532(7597):64-8. https://doi.org/10.1038/nature17625

Bibtex

@article{c22372647c0e4501bdc7d6d92868610d,
title = "Candidalysin is a fungal peptide toxin critical for mucosal infection",
abstract = "Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. Such toxins have not been identified previously in human pathogenic fungi. Here we identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans. This secreted toxin directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity. Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide, which triggers an inward current concomitant with calcium influx. C. albicans strains lacking this toxin do not activate or damage epithelial cells and are avirulent in animal models of mucosal infection. We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical molecular determinant of epithelial damage and host recognition of the clinically important fungus, C. albicans. ",
keywords = "Calcium, Candida albicans, Candidiasis, Cell Membrane Permeability, Cytotoxins, Epithelial Cells, Fungal Proteins, Host-Pathogen Interactions, Humans, Mucous Membrane, Mycotoxins, Signal Transduction, Virulence, Virulence Factors, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Moyes, {David L} and Duncan Wilson and Richardson, {Jonathan P} and Selene Mogavero and Tang, {Shirley X} and Julia Wernecke and Sarah H{\"o}fs and Gratacap, {Remi L} and Jon Robbins and Manohursingh Runglall and Celia Murciano and Mariana Blagojevic and Selvam Thavaraj and F{\"o}rster, {Toni M} and Betty Hebecker and Lydia Kasper and Gema Vizcay and Iancu, {Simona I} and Nessim Kichik and Antje H{\"a}der and Oliver Kurzai and Ting Luo and Thomas Kr{\"u}ger and Olaf Kniemeyer and Ernesto Cota and Oliver Bader and Wheeler, {Robert T} and Thomas Gutsmann and Bernhard Hube and Naglik, {Julian R}",
year = "2016",
month = apr,
day = "7",
doi = "10.1038/nature17625",
language = "English",
volume = "532",
pages = "64--8",
journal = "NATURE",
issn = "0028-0836",
publisher = "NATURE PUBLISHING GROUP",
number = "7597",

}

RIS

TY - JOUR

T1 - Candidalysin is a fungal peptide toxin critical for mucosal infection

AU - Moyes, David L

AU - Wilson, Duncan

AU - Richardson, Jonathan P

AU - Mogavero, Selene

AU - Tang, Shirley X

AU - Wernecke, Julia

AU - Höfs, Sarah

AU - Gratacap, Remi L

AU - Robbins, Jon

AU - Runglall, Manohursingh

AU - Murciano, Celia

AU - Blagojevic, Mariana

AU - Thavaraj, Selvam

AU - Förster, Toni M

AU - Hebecker, Betty

AU - Kasper, Lydia

AU - Vizcay, Gema

AU - Iancu, Simona I

AU - Kichik, Nessim

AU - Häder, Antje

AU - Kurzai, Oliver

AU - Luo, Ting

AU - Krüger, Thomas

AU - Kniemeyer, Olaf

AU - Cota, Ernesto

AU - Bader, Oliver

AU - Wheeler, Robert T

AU - Gutsmann, Thomas

AU - Hube, Bernhard

AU - Naglik, Julian R

PY - 2016/4/7

Y1 - 2016/4/7

N2 - Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. Such toxins have not been identified previously in human pathogenic fungi. Here we identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans. This secreted toxin directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity. Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide, which triggers an inward current concomitant with calcium influx. C. albicans strains lacking this toxin do not activate or damage epithelial cells and are avirulent in animal models of mucosal infection. We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical molecular determinant of epithelial damage and host recognition of the clinically important fungus, C. albicans.

AB - Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. Such toxins have not been identified previously in human pathogenic fungi. Here we identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans. This secreted toxin directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity. Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide, which triggers an inward current concomitant with calcium influx. C. albicans strains lacking this toxin do not activate or damage epithelial cells and are avirulent in animal models of mucosal infection. We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical molecular determinant of epithelial damage and host recognition of the clinically important fungus, C. albicans.

KW - Calcium

KW - Candida albicans

KW - Candidiasis

KW - Cell Membrane Permeability

KW - Cytotoxins

KW - Epithelial Cells

KW - Fungal Proteins

KW - Host-Pathogen Interactions

KW - Humans

KW - Mucous Membrane

KW - Mycotoxins

KW - Signal Transduction

KW - Virulence

KW - Virulence Factors

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/nature17625

DO - 10.1038/nature17625

M3 - SCORING: Journal article

C2 - 27027296

VL - 532

SP - 64

EP - 68

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 7597

ER -