PortalPublikationenCan alcohol control policies reduce cirrhosis mortality? An ...

Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania

Standard

Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania. / Tran, Alexander; Jiang, Huan; Lange, Shannon; Manthey, Jakob; Štelemėkas, Mindaugas; Badaras, Robertas; Petkevičienė, Janina; Radišauskas, Ričardas; Room, Robin; Rehm, Jürgen.

in: LIVER INT, Jahrgang 42, Nr. 4, 04.2022, S. 765-774.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tran, A, Jiang, H, Lange, S, Manthey, J, Štelemėkas, M, Badaras, R, Petkevičienė, J, Radišauskas, R, Room, R & Rehm, J 2022, 'Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania', LIVER INT, Jg. 42, Nr. 4, S. 765-774. https://doi.org/10.1111/liv.15151

APA

Tran, A., Jiang, H., Lange, S., Manthey, J., Štelemėkas, M., Badaras, R., Petkevičienė, J., Radišauskas, R., Room, R., & Rehm, J. (2022). Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania. LIVER INT, 42(4), 765-774. https://doi.org/10.1111/liv.15151

Vancouver

Tran A, Jiang H, Lange S, Manthey J, Štelemėkas M, Badaras R et al. Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania. LIVER INT. 2022 Apr;42(4):765-774. https://doi.org/10.1111/liv.15151

Bibtex

@article{f6abb8c665cb4bbe9224de85d16a5e9a,
title = "Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania",
abstract = "BACKGROUND AND AIMS: The relationship between alcohol consumption and cirrhosis is well established. Policies that can influence population-level use of alcohol should, in turn, impact cirrhosis. We examined the effect of population-level alcohol control policies on cirrhosis mortality rates in Lithuania - a high-income European Union country with high levels of alcohol consumption.METHODS: Age-standardized, monthly liver mortality data (deaths per 100,000 adults, aged 15+) from Lithuania were analysed from 2001 to 2018 (n = 216 months) while controlling for economic confounders (gross domestic product and inflation). An interrupted time-series analysis was conducted to estimate the effect of three alcohol control policies implemented in 2008, 2017 and 2018 and the number of cirrhosis deaths averted.RESULTS: There was a significant effect of the 2008 (P < .0001) and 2017 (P = .0003) alcohol control policies but a null effect of the 2018 policy (P = .40). Following the 2008 policy, the cirrhosis mortality rate dropped from 4.93 to 3.41 (95% CI: 3.02-3.80) deaths per 100,000 adults, which equated to 493 deaths averted. Further, we found that following the 2017 policy, the mortality rate dropped from 2.85 to 2.01 (95% CI: 1.50-2.52) deaths per 100,000 adults, corresponding to 245 deaths averted.CONCLUSIONS: Our findings support the hypothesis that alcohol control policies can have a significant, immediate effect on cirrhosis mortality. These policy measures are cost-effective and aid in reducing the burden of liver disease.",
keywords = "Adolescent, Adult, Alcohol Drinking/epidemiology, Ethanol, Humans, Lithuania/epidemiology, Liver Cirrhosis, Public Policy",
author = "Alexander Tran and Huan Jiang and Shannon Lange and Jakob Manthey and Mindaugas {\v S}telemėkas and Robertas Badaras and Janina Petkevi{\v c}ienė and Ri{\v c}ardas Radi{\v s}auskas and Robin Room and J{\"u}rgen Rehm",
note = "{\textcopyright} 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2022",
month = apr,
doi = "10.1111/liv.15151",
language = "English",
volume = "42",
pages = "765--774",
journal = "LIVER INT",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania

AU - Tran, Alexander

AU - Jiang, Huan

AU - Lange, Shannon

AU - Manthey, Jakob

AU - Štelemėkas, Mindaugas

AU - Badaras, Robertas

AU - Petkevičienė, Janina

AU - Radišauskas, Ričardas

AU - Room, Robin

AU - Rehm, Jürgen

N1 - © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND AND AIMS: The relationship between alcohol consumption and cirrhosis is well established. Policies that can influence population-level use of alcohol should, in turn, impact cirrhosis. We examined the effect of population-level alcohol control policies on cirrhosis mortality rates in Lithuania - a high-income European Union country with high levels of alcohol consumption.METHODS: Age-standardized, monthly liver mortality data (deaths per 100,000 adults, aged 15+) from Lithuania were analysed from 2001 to 2018 (n = 216 months) while controlling for economic confounders (gross domestic product and inflation). An interrupted time-series analysis was conducted to estimate the effect of three alcohol control policies implemented in 2008, 2017 and 2018 and the number of cirrhosis deaths averted.RESULTS: There was a significant effect of the 2008 (P < .0001) and 2017 (P = .0003) alcohol control policies but a null effect of the 2018 policy (P = .40). Following the 2008 policy, the cirrhosis mortality rate dropped from 4.93 to 3.41 (95% CI: 3.02-3.80) deaths per 100,000 adults, which equated to 493 deaths averted. Further, we found that following the 2017 policy, the mortality rate dropped from 2.85 to 2.01 (95% CI: 1.50-2.52) deaths per 100,000 adults, corresponding to 245 deaths averted.CONCLUSIONS: Our findings support the hypothesis that alcohol control policies can have a significant, immediate effect on cirrhosis mortality. These policy measures are cost-effective and aid in reducing the burden of liver disease.

AB - BACKGROUND AND AIMS: The relationship between alcohol consumption and cirrhosis is well established. Policies that can influence population-level use of alcohol should, in turn, impact cirrhosis. We examined the effect of population-level alcohol control policies on cirrhosis mortality rates in Lithuania - a high-income European Union country with high levels of alcohol consumption.METHODS: Age-standardized, monthly liver mortality data (deaths per 100,000 adults, aged 15+) from Lithuania were analysed from 2001 to 2018 (n = 216 months) while controlling for economic confounders (gross domestic product and inflation). An interrupted time-series analysis was conducted to estimate the effect of three alcohol control policies implemented in 2008, 2017 and 2018 and the number of cirrhosis deaths averted.RESULTS: There was a significant effect of the 2008 (P < .0001) and 2017 (P = .0003) alcohol control policies but a null effect of the 2018 policy (P = .40). Following the 2008 policy, the cirrhosis mortality rate dropped from 4.93 to 3.41 (95% CI: 3.02-3.80) deaths per 100,000 adults, which equated to 493 deaths averted. Further, we found that following the 2017 policy, the mortality rate dropped from 2.85 to 2.01 (95% CI: 1.50-2.52) deaths per 100,000 adults, corresponding to 245 deaths averted.CONCLUSIONS: Our findings support the hypothesis that alcohol control policies can have a significant, immediate effect on cirrhosis mortality. These policy measures are cost-effective and aid in reducing the burden of liver disease.

KW - Adolescent

KW - Adult

KW - Alcohol Drinking/epidemiology

KW - Ethanol

KW - Humans

KW - Lithuania/epidemiology

KW - Liver Cirrhosis

KW - Public Policy

U2 - 10.1111/liv.15151

DO - 10.1111/liv.15151

M3 - SCORING: Journal article

C2 - 35023617

VL - 42

SP - 765

EP - 774

JO - LIVER INT

JF - LIVER INT

SN - 1478-3223

IS - 4

ER -