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Calcitonin gene related peptide mediates cardioprotection by remote preconditioning

Standard

Calcitonin gene related peptide mediates cardioprotection by remote preconditioning. / Wolfrum, Sebastian; Nienstedt, Julie; Heidbreder, Marc; Schneider, Kathrin; Dominiak, Peter; Dendorfer, Andreas.

in: REGUL PEPTIDES, Jahrgang 127, Nr. 1-3, 15.04.2005, S. 217-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wolfrum, S, Nienstedt, J, Heidbreder, M, Schneider, K, Dominiak, P & Dendorfer, A 2005, 'Calcitonin gene related peptide mediates cardioprotection by remote preconditioning', REGUL PEPTIDES, Jg. 127, Nr. 1-3, S. 217-24. https://doi.org/10.1016/j.regpep.2004.12.008

APA

Wolfrum, S., Nienstedt, J., Heidbreder, M., Schneider, K., Dominiak, P., & Dendorfer, A. (2005). Calcitonin gene related peptide mediates cardioprotection by remote preconditioning. REGUL PEPTIDES, 127(1-3), 217-24. https://doi.org/10.1016/j.regpep.2004.12.008

Vancouver

Wolfrum S, Nienstedt J, Heidbreder M, Schneider K, Dominiak P, Dendorfer A. Calcitonin gene related peptide mediates cardioprotection by remote preconditioning. REGUL PEPTIDES. 2005 Apr 15;127(1-3):217-24. https://doi.org/10.1016/j.regpep.2004.12.008

Bibtex

@article{626176df9e3841df8ead29bde6b606e4,
title = "Calcitonin gene related peptide mediates cardioprotection by remote preconditioning",
abstract = "Excitation of sensory nerves and activation of myocardial protein kinase C (PKC) epsilon contribute to the transduction of remote preconditioning (RPC) to the heart. Since calcitonin gene related peptide (CGRP) is an important mediator of sensory neurons we tried to delineate whether CGRP a) protects the heart from ischemic injury, b) is involved in cardioprotection after RPC, and c) leads to an activation of myocardial PKCepsilon. RPC was achieved by brief mesenteric artery occlusion followed by reperfusion. Myocardial infarct size (IS) was measured by TTC staining after temporary coronary artery occlusion (CAO) in rats. CGRP plasma levels were determined by radioimmunoassay and PKCepsilon was measured by quantitative immunoblotting. CGRP infusion reduced infarct size by 57%, an action that was abolished after co-treatment with the PKC inhibitor chelerythrine. RPC significantly increased CGRP plasma levels, reduced infarct size, and activated myocardial PKCepsilon. Infarct size reduction was abolished and PKCepsilon activation was significantly attenuated by CGRP(8-37), a specific CGRP receptor antagonist. Ganglion blockade with hexamethonium did not influence CGRP release by RPC but abolished CGRP mediated myocardial PKCepsilon activation. In conclusion, CGRP protects the heart from ischemic injury and is involved in RPC, presumably by activating myocardial PKCepsilon.",
keywords = "Animals, Blood Pressure, Calcitonin Gene-Related Peptide, Cardiotonic Agents, Dose-Response Relationship, Drug, Enzyme Activation, Heart, Ischemic Preconditioning, Myocardial, Male, Myocardial Infarction, Myocardial Ischemia, Neurons, Afferent, Protein Kinase C, Protein Kinase C-epsilon, Random Allocation, Rats, Rats, Wistar, Journal Article",
author = "Sebastian Wolfrum and Julie Nienstedt and Marc Heidbreder and Kathrin Schneider and Peter Dominiak and Andreas Dendorfer",
year = "2005",
month = apr,
day = "15",
doi = "10.1016/j.regpep.2004.12.008",
language = "English",
volume = "127",
pages = "217--24",
journal = "REGUL PEPTIDES",
issn = "0167-0115",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Calcitonin gene related peptide mediates cardioprotection by remote preconditioning

AU - Wolfrum, Sebastian

AU - Nienstedt, Julie

AU - Heidbreder, Marc

AU - Schneider, Kathrin

AU - Dominiak, Peter

AU - Dendorfer, Andreas

PY - 2005/4/15

Y1 - 2005/4/15

N2 - Excitation of sensory nerves and activation of myocardial protein kinase C (PKC) epsilon contribute to the transduction of remote preconditioning (RPC) to the heart. Since calcitonin gene related peptide (CGRP) is an important mediator of sensory neurons we tried to delineate whether CGRP a) protects the heart from ischemic injury, b) is involved in cardioprotection after RPC, and c) leads to an activation of myocardial PKCepsilon. RPC was achieved by brief mesenteric artery occlusion followed by reperfusion. Myocardial infarct size (IS) was measured by TTC staining after temporary coronary artery occlusion (CAO) in rats. CGRP plasma levels were determined by radioimmunoassay and PKCepsilon was measured by quantitative immunoblotting. CGRP infusion reduced infarct size by 57%, an action that was abolished after co-treatment with the PKC inhibitor chelerythrine. RPC significantly increased CGRP plasma levels, reduced infarct size, and activated myocardial PKCepsilon. Infarct size reduction was abolished and PKCepsilon activation was significantly attenuated by CGRP(8-37), a specific CGRP receptor antagonist. Ganglion blockade with hexamethonium did not influence CGRP release by RPC but abolished CGRP mediated myocardial PKCepsilon activation. In conclusion, CGRP protects the heart from ischemic injury and is involved in RPC, presumably by activating myocardial PKCepsilon.

AB - Excitation of sensory nerves and activation of myocardial protein kinase C (PKC) epsilon contribute to the transduction of remote preconditioning (RPC) to the heart. Since calcitonin gene related peptide (CGRP) is an important mediator of sensory neurons we tried to delineate whether CGRP a) protects the heart from ischemic injury, b) is involved in cardioprotection after RPC, and c) leads to an activation of myocardial PKCepsilon. RPC was achieved by brief mesenteric artery occlusion followed by reperfusion. Myocardial infarct size (IS) was measured by TTC staining after temporary coronary artery occlusion (CAO) in rats. CGRP plasma levels were determined by radioimmunoassay and PKCepsilon was measured by quantitative immunoblotting. CGRP infusion reduced infarct size by 57%, an action that was abolished after co-treatment with the PKC inhibitor chelerythrine. RPC significantly increased CGRP plasma levels, reduced infarct size, and activated myocardial PKCepsilon. Infarct size reduction was abolished and PKCepsilon activation was significantly attenuated by CGRP(8-37), a specific CGRP receptor antagonist. Ganglion blockade with hexamethonium did not influence CGRP release by RPC but abolished CGRP mediated myocardial PKCepsilon activation. In conclusion, CGRP protects the heart from ischemic injury and is involved in RPC, presumably by activating myocardial PKCepsilon.

KW - Animals

KW - Blood Pressure

KW - Calcitonin Gene-Related Peptide

KW - Cardiotonic Agents

KW - Dose-Response Relationship, Drug

KW - Enzyme Activation

KW - Heart

KW - Ischemic Preconditioning, Myocardial

KW - Male

KW - Myocardial Infarction

KW - Myocardial Ischemia

KW - Neurons, Afferent

KW - Protein Kinase C

KW - Protein Kinase C-epsilon

KW - Random Allocation

KW - Rats

KW - Rats, Wistar

KW - Journal Article

U2 - 10.1016/j.regpep.2004.12.008

DO - 10.1016/j.regpep.2004.12.008

M3 - SCORING: Journal article

C2 - 15680490

VL - 127

SP - 217

EP - 224

JO - REGUL PEPTIDES

JF - REGUL PEPTIDES

SN - 0167-0115

IS - 1-3

ER -