Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus
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Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus : Close electrophysiological encounters of the third kind. / Anstötz, Max; Quattrocolo, Giulia; Maccaferri, Gianmaria.
in: BRAIN RES, Jahrgang 1697, 15.10.2018, S. 124-133.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus
T2 - Close electrophysiological encounters of the third kind
AU - Anstötz, Max
AU - Quattrocolo, Giulia
AU - Maccaferri, Gianmaria
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2018/10/15
Y1 - 2018/10/15
N2 - In contrast to the large number of studies investigating the electrophysiological properties and synaptic connectivity of hippocampal pyramidal neurons, granule cells, and GABAergic interneurons, much less is known about Cajal-Retzius cells. In this review article, we discuss the possible reasons underlying this difference, and review experimental work performed on this cell type in the hippocampus, comparing it with results obtained in the neocortex. Our main emphasis is on data obtained with in vitro electrophysiology. In particular, we address the bidirectional connectivity between Cajal-Retzius cells and GABAergic interneurons, examine their synaptic properties and propose specific functions of Cajal-Retzius cell/GABAergic interneuron microcircuits. Lastly, we discuss the potential involvement of these microcircuits in critical physiological hippocampal functions such as postnatal neurogenesis or pathological scenarios such as temporal lobe epilepsy.
AB - In contrast to the large number of studies investigating the electrophysiological properties and synaptic connectivity of hippocampal pyramidal neurons, granule cells, and GABAergic interneurons, much less is known about Cajal-Retzius cells. In this review article, we discuss the possible reasons underlying this difference, and review experimental work performed on this cell type in the hippocampus, comparing it with results obtained in the neocortex. Our main emphasis is on data obtained with in vitro electrophysiology. In particular, we address the bidirectional connectivity between Cajal-Retzius cells and GABAergic interneurons, examine their synaptic properties and propose specific functions of Cajal-Retzius cell/GABAergic interneuron microcircuits. Lastly, we discuss the potential involvement of these microcircuits in critical physiological hippocampal functions such as postnatal neurogenesis or pathological scenarios such as temporal lobe epilepsy.
KW - Journal Article
KW - Review
U2 - 10.1016/j.brainres.2018.07.028
DO - 10.1016/j.brainres.2018.07.028
M3 - SCORING: Review article
C2 - 30071194
VL - 1697
SP - 124
EP - 133
JO - BRAIN RES
JF - BRAIN RES
SN - 0006-8993
ER -