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Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1.

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Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1. / Schwoerer, Alexander; Zenouzi, Roman; Ehmke, Heimo; Friederich, Patrick.

in: ANESTH ANALG, Jahrgang 113, Nr. 6, 6, 2011, S. 1365-1373.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schwoerer, A, Zenouzi, R, Ehmke, H & Friederich, P 2011, 'Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1.', ANESTH ANALG, Jg. 113, Nr. 6, 6, S. 1365-1373. <http://www.ncbi.nlm.nih.gov/pubmed/22003215?dopt=Citation>

APA

Schwoerer, A., Zenouzi, R., Ehmke, H., & Friederich, P. (2011). Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1. ANESTH ANALG, 113(6), 1365-1373. [6]. http://www.ncbi.nlm.nih.gov/pubmed/22003215?dopt=Citation

Vancouver

Schwoerer A, Zenouzi R, Ehmke H, Friederich P. Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1. ANESTH ANALG. 2011;113(6):1365-1373. 6.

Bibtex

@article{4b78a8d8e7614f56bd52f3813b534efb,
title = "Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1.",
abstract = "The effects of the local anesthetic bupivacaine on cardiac action potentials (APs) are mainly attributed to inhibition of cardiac Na(+) channels. The relevance of its ability to also induce high-affinity blockade of human ether-{\`a}-gogo-related gene (hERG) channels is unclear. We investigated whether this interaction may functionally become more significant in cellular and computational models of long (L)QT syndromes.",
keywords = "Animals, Male, Guinea Pigs, Action Potentials/drug effects/*physiology, Bupivacaine/*pharmacology, *Computer Simulation, Ether-A-Go-Go Potassium Channels/antagonists & inhibitors/physiology, Myocytes, Cardiac/drug effects/*physiology, Romano-Ward Syndrome/metabolism/*pathology/*physiopathology, Animals, Male, Guinea Pigs, Action Potentials/drug effects/*physiology, Bupivacaine/*pharmacology, *Computer Simulation, Ether-A-Go-Go Potassium Channels/antagonists & inhibitors/physiology, Myocytes, Cardiac/drug effects/*physiology, Romano-Ward Syndrome/metabolism/*pathology/*physiopathology",
author = "Alexander Schwoerer and Roman Zenouzi and Heimo Ehmke and Patrick Friederich",
year = "2011",
language = "English",
volume = "113",
pages = "1365--1373",
journal = "ANESTH ANALG",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1.

AU - Schwoerer, Alexander

AU - Zenouzi, Roman

AU - Ehmke, Heimo

AU - Friederich, Patrick

PY - 2011

Y1 - 2011

N2 - The effects of the local anesthetic bupivacaine on cardiac action potentials (APs) are mainly attributed to inhibition of cardiac Na(+) channels. The relevance of its ability to also induce high-affinity blockade of human ether-à-gogo-related gene (hERG) channels is unclear. We investigated whether this interaction may functionally become more significant in cellular and computational models of long (L)QT syndromes.

AB - The effects of the local anesthetic bupivacaine on cardiac action potentials (APs) are mainly attributed to inhibition of cardiac Na(+) channels. The relevance of its ability to also induce high-affinity blockade of human ether-à-gogo-related gene (hERG) channels is unclear. We investigated whether this interaction may functionally become more significant in cellular and computational models of long (L)QT syndromes.

KW - Animals

KW - Male

KW - Guinea Pigs

KW - Action Potentials/drug effects/physiology

KW - Bupivacaine/pharmacology

KW - Computer Simulation

KW - Ether-A-Go-Go Potassium Channels/antagonists & inhibitors/physiology

KW - Myocytes, Cardiac/drug effects/physiology

KW - Romano-Ward Syndrome/metabolism/pathology/physiopathology

KW - Animals

KW - Male

KW - Guinea Pigs

KW - Action Potentials/drug effects/physiology

KW - Bupivacaine/pharmacology

KW - Computer Simulation

KW - Ether-A-Go-Go Potassium Channels/antagonists & inhibitors/physiology

KW - Myocytes, Cardiac/drug effects/physiology

KW - Romano-Ward Syndrome/metabolism/pathology/physiopathology

M3 - SCORING: Journal article

VL - 113

SP - 1365

EP - 1373

JO - ANESTH ANALG

JF - ANESTH ANALG

SN - 0003-2999

IS - 6

M1 - 6

ER -