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Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

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Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. / Berbée, Jimmy F P; Boon, Mariëtte R; Khedoe, P Padmini S J; Bartelt, Alexander; Schlein, Christian; Worthmann, Anna; Kooijman, Sander; Hoeke, Geerte; Mol, Isabel M; John, Clara; Jung, Caroline; Vazirpanah, Nadia; Brouwers, Linda P J; Gordts, Philip L S M; Esko, Jeffrey D; Hiemstra, Pieter S; Havekes, Louis M; Scheja, Ludger; Heeren, Joerg; Rensen, Patrick C N.

in: NAT COMMUN, Jahrgang 6, 2015, S. 6356.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Berbée, JFP, Boon, MR, Khedoe, PPSJ, Bartelt, A, Schlein, C, Worthmann, A, Kooijman, S, Hoeke, G, Mol, IM, John, C, Jung, C, Vazirpanah, N, Brouwers, LPJ, Gordts, PLSM, Esko, JD, Hiemstra, PS, Havekes, LM, Scheja, L, Heeren, J & Rensen, PCN 2015, 'Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development', NAT COMMUN, Jg. 6, S. 6356. https://doi.org/10.1038/ncomms7356

APA

Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J., & Rensen, P. C. N. (2015). Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. NAT COMMUN, 6, 6356. https://doi.org/10.1038/ncomms7356

Vancouver

Berbée JFP, Boon MR, Khedoe PPSJ, Bartelt A, Schlein C, Worthmann A et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. NAT COMMUN. 2015;6:6356. https://doi.org/10.1038/ncomms7356

Bibtex

@article{764fd5b6d53b40f390de4bd77a51d475,
title = "Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development",
abstract = "Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by β3-adrenergic receptor stimulation protects from atherosclerosis in hyperlipidemic APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism that unlike hyperlipidemic Apoe(-/-) and Ldlr(-/-) mice expresses functional apoE and LDLR. BAT activation increases energy expenditure and decreases plasma triglyceride and cholesterol levels. Mechanistically, we demonstrate that BAT activation enhances the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT, subsequently accelerating the hepatic clearance of the cholesterol-enriched remnants. These effects depend on a functional hepatic apoE-LDLR clearance pathway as BAT activation in Apoe(-/-) and Ldlr(-/-) mice does not attenuate hypercholesterolaemia and atherosclerosis. We conclude that activation of BAT is a powerful therapeutic avenue to ameliorate hyperlipidaemia and protect from atherosclerosis.",
author = "Berb{\'e}e, {Jimmy F P} and Boon, {Mari{\"e}tte R} and Khedoe, {P Padmini S J} and Alexander Bartelt and Christian Schlein and Anna Worthmann and Sander Kooijman and Geerte Hoeke and Mol, {Isabel M} and Clara John and Caroline Jung and Nadia Vazirpanah and Brouwers, {Linda P J} and Gordts, {Philip L S M} and Esko, {Jeffrey D} and Hiemstra, {Pieter S} and Havekes, {Louis M} and Ludger Scheja and Joerg Heeren and Rensen, {Patrick C N}",
year = "2015",
doi = "10.1038/ncomms7356",
language = "English",
volume = "6",
pages = "6356",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

AU - Berbée, Jimmy F P

AU - Boon, Mariëtte R

AU - Khedoe, P Padmini S J

AU - Bartelt, Alexander

AU - Schlein, Christian

AU - Worthmann, Anna

AU - Kooijman, Sander

AU - Hoeke, Geerte

AU - Mol, Isabel M

AU - John, Clara

AU - Jung, Caroline

AU - Vazirpanah, Nadia

AU - Brouwers, Linda P J

AU - Gordts, Philip L S M

AU - Esko, Jeffrey D

AU - Hiemstra, Pieter S

AU - Havekes, Louis M

AU - Scheja, Ludger

AU - Heeren, Joerg

AU - Rensen, Patrick C N

PY - 2015

Y1 - 2015

N2 - Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by β3-adrenergic receptor stimulation protects from atherosclerosis in hyperlipidemic APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism that unlike hyperlipidemic Apoe(-/-) and Ldlr(-/-) mice expresses functional apoE and LDLR. BAT activation increases energy expenditure and decreases plasma triglyceride and cholesterol levels. Mechanistically, we demonstrate that BAT activation enhances the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT, subsequently accelerating the hepatic clearance of the cholesterol-enriched remnants. These effects depend on a functional hepatic apoE-LDLR clearance pathway as BAT activation in Apoe(-/-) and Ldlr(-/-) mice does not attenuate hypercholesterolaemia and atherosclerosis. We conclude that activation of BAT is a powerful therapeutic avenue to ameliorate hyperlipidaemia and protect from atherosclerosis.

AB - Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by β3-adrenergic receptor stimulation protects from atherosclerosis in hyperlipidemic APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism that unlike hyperlipidemic Apoe(-/-) and Ldlr(-/-) mice expresses functional apoE and LDLR. BAT activation increases energy expenditure and decreases plasma triglyceride and cholesterol levels. Mechanistically, we demonstrate that BAT activation enhances the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT, subsequently accelerating the hepatic clearance of the cholesterol-enriched remnants. These effects depend on a functional hepatic apoE-LDLR clearance pathway as BAT activation in Apoe(-/-) and Ldlr(-/-) mice does not attenuate hypercholesterolaemia and atherosclerosis. We conclude that activation of BAT is a powerful therapeutic avenue to ameliorate hyperlipidaemia and protect from atherosclerosis.

U2 - 10.1038/ncomms7356

DO - 10.1038/ncomms7356

M3 - SCORING: Journal article

C2 - 25754609

VL - 6

SP - 6356

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -