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Brown adipose tissue activity controls triglyceride clearance.

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Brown adipose tissue activity controls triglyceride clearance. / Bartelt, Alexander; Bruns, Oliver T; Reimer, Rudolph; Hohenberg, Heinz; Ittrich, Harald; Peldschus, Kersten; Kaul, Michael; Tromsdorf, Ulrich I; Weller, Horst; Waurisch, Christian; Eychmüller, Alexander; Gordts, Philip L S M; Rinninger, Franz; Brügelmann, Karoline; Freund, Barbara; Nielsen, Peter; Merkel, Martin; Heeren, Jörg.

in: NAT MED, Jahrgang 17, Nr. 2, 2, 2011, S. 200-205.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bartelt, A, Bruns, OT, Reimer, R, Hohenberg, H, Ittrich, H, Peldschus, K, Kaul, M, Tromsdorf, UI, Weller, H, Waurisch, C, Eychmüller, A, Gordts, PLSM, Rinninger, F, Brügelmann, K, Freund, B, Nielsen, P, Merkel, M & Heeren, J 2011, 'Brown adipose tissue activity controls triglyceride clearance.', NAT MED, Jg. 17, Nr. 2, 2, S. 200-205. <http://www.ncbi.nlm.nih.gov/pubmed/21258337?dopt=Citation>

APA

Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M., Tromsdorf, U. I., Weller, H., Waurisch, C., Eychmüller, A., Gordts, P. L. S. M., Rinninger, F., Brügelmann, K., Freund, B., Nielsen, P., Merkel, M., & Heeren, J. (2011). Brown adipose tissue activity controls triglyceride clearance. NAT MED, 17(2), 200-205. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21258337?dopt=Citation

Vancouver

Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K et al. Brown adipose tissue activity controls triglyceride clearance. NAT MED. 2011;17(2):200-205. 2.

Bibtex

@article{4868fc7a0e464d41b6344e99137d8bd8,
title = "Brown adipose tissue activity controls triglyceride clearance.",
abstract = "Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against cold and has recently been shown to be present in humans. Triglyceride-rich lipoproteins (TRLs) transport lipids in the bloodstream, where the fatty acid moieties are liberated by the action of lipoprotein lipase (LPL). Peripheral organs such as muscle and adipose tissue take up the fatty acids, whereas the remaining cholesterol-rich remnant particles are cleared by the liver. Elevated plasma triglyceride concentrations and prolonged circulation of cholesterol-rich remnants, especially in diabetic dyslipidemia, are risk factors for cardiovascular disease. However, the precise biological role of BAT for TRL clearance remains unclear. Here we show that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice. Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and transmembrane receptor CD36. In pathophysiological settings, cold exposure corrected hyperlipidemia and improved deleterious effects of insulin resistance. In conclusion, BAT activity controls vascular lipoprotein homeostasis by inducing a metabolic program that boosts TRL turnover and channels lipids into BAT. Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.",
author = "Alexander Bartelt and Bruns, {Oliver T} and Rudolph Reimer and Heinz Hohenberg and Harald Ittrich and Kersten Peldschus and Michael Kaul and Tromsdorf, {Ulrich I} and Horst Weller and Christian Waurisch and Alexander Eychm{\"u}ller and Gordts, {Philip L S M} and Franz Rinninger and Karoline Br{\"u}gelmann and Barbara Freund and Peter Nielsen and Martin Merkel and J{\"o}rg Heeren",
year = "2011",
language = "Deutsch",
volume = "17",
pages = "200--205",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Brown adipose tissue activity controls triglyceride clearance.

AU - Bartelt, Alexander

AU - Bruns, Oliver T

AU - Reimer, Rudolph

AU - Hohenberg, Heinz

AU - Ittrich, Harald

AU - Peldschus, Kersten

AU - Kaul, Michael

AU - Tromsdorf, Ulrich I

AU - Weller, Horst

AU - Waurisch, Christian

AU - Eychmüller, Alexander

AU - Gordts, Philip L S M

AU - Rinninger, Franz

AU - Brügelmann, Karoline

AU - Freund, Barbara

AU - Nielsen, Peter

AU - Merkel, Martin

AU - Heeren, Jörg

PY - 2011

Y1 - 2011

N2 - Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against cold and has recently been shown to be present in humans. Triglyceride-rich lipoproteins (TRLs) transport lipids in the bloodstream, where the fatty acid moieties are liberated by the action of lipoprotein lipase (LPL). Peripheral organs such as muscle and adipose tissue take up the fatty acids, whereas the remaining cholesterol-rich remnant particles are cleared by the liver. Elevated plasma triglyceride concentrations and prolonged circulation of cholesterol-rich remnants, especially in diabetic dyslipidemia, are risk factors for cardiovascular disease. However, the precise biological role of BAT for TRL clearance remains unclear. Here we show that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice. Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and transmembrane receptor CD36. In pathophysiological settings, cold exposure corrected hyperlipidemia and improved deleterious effects of insulin resistance. In conclusion, BAT activity controls vascular lipoprotein homeostasis by inducing a metabolic program that boosts TRL turnover and channels lipids into BAT. Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.

AB - Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against cold and has recently been shown to be present in humans. Triglyceride-rich lipoproteins (TRLs) transport lipids in the bloodstream, where the fatty acid moieties are liberated by the action of lipoprotein lipase (LPL). Peripheral organs such as muscle and adipose tissue take up the fatty acids, whereas the remaining cholesterol-rich remnant particles are cleared by the liver. Elevated plasma triglyceride concentrations and prolonged circulation of cholesterol-rich remnants, especially in diabetic dyslipidemia, are risk factors for cardiovascular disease. However, the precise biological role of BAT for TRL clearance remains unclear. Here we show that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice. Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and transmembrane receptor CD36. In pathophysiological settings, cold exposure corrected hyperlipidemia and improved deleterious effects of insulin resistance. In conclusion, BAT activity controls vascular lipoprotein homeostasis by inducing a metabolic program that boosts TRL turnover and channels lipids into BAT. Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.

M3 - SCORING: Zeitschriftenaufsatz

VL - 17

SP - 200

EP - 205

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 2

M1 - 2

ER -