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Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

Standard

Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. / Schmidt, Nils-Ole; Przylecki, Wojciech; Yang, Wendy; Ziu, Mateo; Teng, Yang; Kim, Seung U; Black, Peter McL; Aboody, Karen S; Carroll, Rona S.

in: NEOPLASIA, Jahrgang 7, Nr. 6, 6, 2005, S. 623-629.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schmidt, N-O, Przylecki, W, Yang, W, Ziu, M, Teng, Y, Kim, SU, Black, PM, Aboody, KS & Carroll, RS 2005, 'Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.', NEOPLASIA, Jg. 7, Nr. 6, 6, S. 623-629. https://doi.org/10.1593/neo.04781

APA

Schmidt, N-O., Przylecki, W., Yang, W., Ziu, M., Teng, Y., Kim, S. U., Black, P. M., Aboody, K. S., & Carroll, R. S. (2005). Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. NEOPLASIA, 7(6), 623-629. [6]. https://doi.org/10.1593/neo.04781

Vancouver

Schmidt N-O, Przylecki W, Yang W, Ziu M, Teng Y, Kim SU et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. NEOPLASIA. 2005;7(6):623-629. 6. https://doi.org/10.1593/neo.04781

Bibtex

@article{3989920823094fc7b78a10d3b4e6bef6,
title = "Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.",
abstract = "The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.",
author = "Nils-Ole Schmidt and Wojciech Przylecki and Wendy Yang and Mateo Ziu and Yang Teng and Kim, {Seung U} and Black, {Peter McL} and Aboody, {Karen S} and Carroll, {Rona S}",
year = "2005",
doi = "10.1593/neo.04781",
language = "Deutsch",
volume = "7",
pages = "623--629",
journal = "NEOPLASIA",
issn = "1476-5586",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

AU - Schmidt, Nils-Ole

AU - Przylecki, Wojciech

AU - Yang, Wendy

AU - Ziu, Mateo

AU - Teng, Yang

AU - Kim, Seung U

AU - Black, Peter McL

AU - Aboody, Karen S

AU - Carroll, Rona S

PY - 2005

Y1 - 2005

N2 - The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.

AB - The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.

U2 - 10.1593/neo.04781

DO - 10.1593/neo.04781

M3 - SCORING: Zeitschriftenaufsatz

VL - 7

SP - 623

EP - 629

JO - NEOPLASIA

JF - NEOPLASIA

SN - 1476-5586

IS - 6

M1 - 6

ER -