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Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms

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Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms. / Chen, Di; Jia, Tianye; Cheng, Wei; Cao, Miao; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny A; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Robbins, T W; Sahakian, Barbara J; Schumann, Gunter; Feng, Jianfeng; IMAGEN Consortium.

in: J AM ACAD CHILD PSY, Jahrgang 61, Nr. 8, 08.2022, S. 1050-1061.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chen, D, Jia, T, Cheng, W, Cao, M, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Flor, H, Grigis, A, Garavan, H, Gowland, PA, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Robbins, TW, Sahakian, BJ, Schumann, G, Feng, J & IMAGEN Consortium 2022, 'Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms', J AM ACAD CHILD PSY, Jg. 61, Nr. 8, S. 1050-1061. https://doi.org/10.1016/j.jaac.2021.11.030

APA

Chen, D., Jia, T., Cheng, W., Cao, M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P. A., Heinz, A., Ittermann, B., Martinot, J-L., Martinot, M-L. P., Nees, F., ... IMAGEN Consortium (2022). Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms. J AM ACAD CHILD PSY, 61(8), 1050-1061. https://doi.org/10.1016/j.jaac.2021.11.030

Vancouver

Chen D, Jia T, Cheng W, Cao M, Banaschewski T, Barker GJ et al. Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms. J AM ACAD CHILD PSY. 2022 Aug;61(8):1050-1061. https://doi.org/10.1016/j.jaac.2021.11.030

Bibtex

@article{2169bcbcc62b4778a95f9393c35a93b5,
title = "Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms",
abstract = "OBJECTIVE: Children experiencing attention-deficit/hyperactivity disorder (ADHD) symptoms may retain symptoms into adulthood, but little is known about the underlying mechanism.METHOD: To identify biomarkers of persistent ADHD symptom development, we carried out whole-brain analyses of neuroimaging data during the anticipation phase of the Monetary-Incentive-Delay (MID) task in 1,368 adolescents recruited by the IMAGEN Consortium at age 14 years, whose behavioral measurements were followed up longitudinally at age 16. In particular, we focused on comparing individuals with persistent high ADHD symptoms at both ages 14 and 16 years to unaffected control individuals, but also exploring which individuals demonstrating symptom remission (with high ADHD symptoms at age 14 but much reduced at age 16).RESULTS: We identified reduced activations in the medial frontal cortex and the thalamus during reward anticipation as neuro-biomarkers for persistent ADHD symptoms across time. The genetic relevance of the above findings was further supported by the associations of the polygenic risk scores of ADHD with both the persistent and control status and the activations of both brain regions. Furthermore, in an exploratory analysis, the thalamic activation might also help to distinguish persons with persistent ADHD from those remitted in both an exploratory sample (odds ratio = 9.43, p < .001) and an independent generalization sample (odds ratio = 4.64, p = .003).CONCLUSION: Using a well-established and widely applied functional magnetic resonance imaging task, we have identified neural biomarkers that could discriminate ADHD symptoms that persist throughout adolescence from controls and potentially those likely to remit during adolescent development as well.",
author = "Di Chen and Tianye Jia and Wei Cheng and Miao Cao and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Gowland, {Penny A} and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Robbins, {T W} and Sahakian, {Barbara J} and Gunter Schumann and Jianfeng Feng and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",
year = "2022",
month = aug,
doi = "10.1016/j.jaac.2021.11.030",
language = "English",
volume = "61",
pages = "1050--1061",
journal = "J AM ACAD CHILD PSY",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - Brain Signatures During Reward Anticipation Predict Persistent Attention-Deficit/Hyperactivity Disorder Symptoms

AU - Chen, Di

AU - Jia, Tianye

AU - Cheng, Wei

AU - Cao, Miao

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny A

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Robbins, T W

AU - Sahakian, Barbara J

AU - Schumann, Gunter

AU - Feng, Jianfeng

AU - IMAGEN Consortium

N1 - Copyright © 2021. Published by Elsevier Inc.

PY - 2022/8

Y1 - 2022/8

N2 - OBJECTIVE: Children experiencing attention-deficit/hyperactivity disorder (ADHD) symptoms may retain symptoms into adulthood, but little is known about the underlying mechanism.METHOD: To identify biomarkers of persistent ADHD symptom development, we carried out whole-brain analyses of neuroimaging data during the anticipation phase of the Monetary-Incentive-Delay (MID) task in 1,368 adolescents recruited by the IMAGEN Consortium at age 14 years, whose behavioral measurements were followed up longitudinally at age 16. In particular, we focused on comparing individuals with persistent high ADHD symptoms at both ages 14 and 16 years to unaffected control individuals, but also exploring which individuals demonstrating symptom remission (with high ADHD symptoms at age 14 but much reduced at age 16).RESULTS: We identified reduced activations in the medial frontal cortex and the thalamus during reward anticipation as neuro-biomarkers for persistent ADHD symptoms across time. The genetic relevance of the above findings was further supported by the associations of the polygenic risk scores of ADHD with both the persistent and control status and the activations of both brain regions. Furthermore, in an exploratory analysis, the thalamic activation might also help to distinguish persons with persistent ADHD from those remitted in both an exploratory sample (odds ratio = 9.43, p < .001) and an independent generalization sample (odds ratio = 4.64, p = .003).CONCLUSION: Using a well-established and widely applied functional magnetic resonance imaging task, we have identified neural biomarkers that could discriminate ADHD symptoms that persist throughout adolescence from controls and potentially those likely to remit during adolescent development as well.

AB - OBJECTIVE: Children experiencing attention-deficit/hyperactivity disorder (ADHD) symptoms may retain symptoms into adulthood, but little is known about the underlying mechanism.METHOD: To identify biomarkers of persistent ADHD symptom development, we carried out whole-brain analyses of neuroimaging data during the anticipation phase of the Monetary-Incentive-Delay (MID) task in 1,368 adolescents recruited by the IMAGEN Consortium at age 14 years, whose behavioral measurements were followed up longitudinally at age 16. In particular, we focused on comparing individuals with persistent high ADHD symptoms at both ages 14 and 16 years to unaffected control individuals, but also exploring which individuals demonstrating symptom remission (with high ADHD symptoms at age 14 but much reduced at age 16).RESULTS: We identified reduced activations in the medial frontal cortex and the thalamus during reward anticipation as neuro-biomarkers for persistent ADHD symptoms across time. The genetic relevance of the above findings was further supported by the associations of the polygenic risk scores of ADHD with both the persistent and control status and the activations of both brain regions. Furthermore, in an exploratory analysis, the thalamic activation might also help to distinguish persons with persistent ADHD from those remitted in both an exploratory sample (odds ratio = 9.43, p < .001) and an independent generalization sample (odds ratio = 4.64, p = .003).CONCLUSION: Using a well-established and widely applied functional magnetic resonance imaging task, we have identified neural biomarkers that could discriminate ADHD symptoms that persist throughout adolescence from controls and potentially those likely to remit during adolescent development as well.

U2 - 10.1016/j.jaac.2021.11.030

DO - 10.1016/j.jaac.2021.11.030

M3 - SCORING: Journal article

C2 - 34954028

VL - 61

SP - 1050

EP - 1061

JO - J AM ACAD CHILD PSY

JF - J AM ACAD CHILD PSY

SN - 0890-8567

IS - 8

ER -