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Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT

Standard

Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT. / Acker, Güliz; Lange, Catharina; Schatka, Imke; Pfeifer, Andreas; Czabanka, Marcus A; Vajkoczy, Peter; Buchert, Ralph.

in: J NUCL MED, Jahrgang 59, Nr. 2, 02.2018, S. 294-298.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Acker, G, Lange, C, Schatka, I, Pfeifer, A, Czabanka, MA, Vajkoczy, P & Buchert, R 2018, 'Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT', J NUCL MED, Jg. 59, Nr. 2, S. 294-298. https://doi.org/10.2967/jnumed.117.195818

APA

Acker, G., Lange, C., Schatka, I., Pfeifer, A., Czabanka, M. A., Vajkoczy, P., & Buchert, R. (2018). Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT. J NUCL MED, 59(2), 294-298. https://doi.org/10.2967/jnumed.117.195818

Vancouver

Acker G, Lange C, Schatka I, Pfeifer A, Czabanka MA, Vajkoczy P et al. Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT. J NUCL MED. 2018 Feb;59(2):294-298. https://doi.org/10.2967/jnumed.117.195818

Bibtex

@article{3764b71c18064f2ba53509ec61fb3602,
title = "Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT",
abstract = "Cerebrovascular reserve capacity (CVRC) is an important parameter for treatment decisions in chronic cerebrovascular diseases. It can be assessed by measuring the acetazolamide-induced change in regional cerebral blood flow using SPECT with 99mTc-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) or PET with 15O-water. Methods: Our database was searched for patients with moyamoya vasculopathy or atherosclerotic cerebrovascular disease who had undergone 15O-water PET after normal 99mTc-HMPAO SPECT results with respect to CVRC. 15O-water PET was analyzed visually and quantitatively. Quantitative analysis was based on parametric CVRC maps generated by voxelwise image subtraction. Results: The search identified 18 patients (43 ± 15 y, 12 moyamoya vasculopathy). PET revealed impaired CVRC in 8 patients (44%). Quantitative analysis confirmed the positive visual findings in 15O-water PET and the negative findings in 99mTc-HMPAO SPECT. Conclusion:15O-water PET enables detection of impaired CVRC in a considerable fraction of symptomatic patients with stenoocclusion and negative 99mTc-HMPAO SPECT.",
keywords = "Journal Article",
author = "G{\"u}liz Acker and Catharina Lange and Imke Schatka and Andreas Pfeifer and Czabanka, {Marcus A} and Peter Vajkoczy and Ralph Buchert",
note = "Copyright {\textcopyright} 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
year = "2018",
month = feb,
doi = "10.2967/jnumed.117.195818",
language = "English",
volume = "59",
pages = "294--298",
journal = "J NUCL MED",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Brain perfusion imaging under acetazolamide challenge for detection of impaired cerebrovascular reserve capacity: positive findings with O-15-water PET in patients with negative Tc-99m-HMPAO SPECT

AU - Acker, Güliz

AU - Lange, Catharina

AU - Schatka, Imke

AU - Pfeifer, Andreas

AU - Czabanka, Marcus A

AU - Vajkoczy, Peter

AU - Buchert, Ralph

N1 - Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PY - 2018/2

Y1 - 2018/2

N2 - Cerebrovascular reserve capacity (CVRC) is an important parameter for treatment decisions in chronic cerebrovascular diseases. It can be assessed by measuring the acetazolamide-induced change in regional cerebral blood flow using SPECT with 99mTc-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) or PET with 15O-water. Methods: Our database was searched for patients with moyamoya vasculopathy or atherosclerotic cerebrovascular disease who had undergone 15O-water PET after normal 99mTc-HMPAO SPECT results with respect to CVRC. 15O-water PET was analyzed visually and quantitatively. Quantitative analysis was based on parametric CVRC maps generated by voxelwise image subtraction. Results: The search identified 18 patients (43 ± 15 y, 12 moyamoya vasculopathy). PET revealed impaired CVRC in 8 patients (44%). Quantitative analysis confirmed the positive visual findings in 15O-water PET and the negative findings in 99mTc-HMPAO SPECT. Conclusion:15O-water PET enables detection of impaired CVRC in a considerable fraction of symptomatic patients with stenoocclusion and negative 99mTc-HMPAO SPECT.

AB - Cerebrovascular reserve capacity (CVRC) is an important parameter for treatment decisions in chronic cerebrovascular diseases. It can be assessed by measuring the acetazolamide-induced change in regional cerebral blood flow using SPECT with 99mTc-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) or PET with 15O-water. Methods: Our database was searched for patients with moyamoya vasculopathy or atherosclerotic cerebrovascular disease who had undergone 15O-water PET after normal 99mTc-HMPAO SPECT results with respect to CVRC. 15O-water PET was analyzed visually and quantitatively. Quantitative analysis was based on parametric CVRC maps generated by voxelwise image subtraction. Results: The search identified 18 patients (43 ± 15 y, 12 moyamoya vasculopathy). PET revealed impaired CVRC in 8 patients (44%). Quantitative analysis confirmed the positive visual findings in 15O-water PET and the negative findings in 99mTc-HMPAO SPECT. Conclusion:15O-water PET enables detection of impaired CVRC in a considerable fraction of symptomatic patients with stenoocclusion and negative 99mTc-HMPAO SPECT.

KW - Journal Article

UR - http://europepmc.org/abstract/med/28729429

U2 - 10.2967/jnumed.117.195818

DO - 10.2967/jnumed.117.195818

M3 - SCORING: Journal article

C2 - 28729429

VL - 59

SP - 294

EP - 298

JO - J NUCL MED

JF - J NUCL MED

SN - 0161-5505

IS - 2

ER -