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Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis

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Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis. / Theleritis, Christos; Fisher, Helen L; Schäfer, Ingo; Winters, Laura E; Stahl, Daniel; Morgan, Craig; Dazzan, Paola; Breedvelt, Josefien; Sambath, Irene; Vitoratou, Silia; Russo, Manuela; Reichenberg, Abraham; Aurora Falcone, M; Mondelli, Valeria; O'Connor, Jennifer; David, Anthony; McGuire, Philip; Pariante, Carmine; Di Forti, Marta; Murray, Robin M; Bonaccorso, Stefania.

in: SCHIZOPHR RES, Jahrgang 159, Nr. 1, 01.10.2014, S. 56-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Theleritis, C, Fisher, HL, Schäfer, I, Winters, LE, Stahl, D, Morgan, C, Dazzan, P, Breedvelt, J, Sambath, I, Vitoratou, S, Russo, M, Reichenberg, A, Aurora Falcone, M, Mondelli, V, O'Connor, J, David, A, McGuire, P, Pariante, C, Di Forti, M, Murray, RM & Bonaccorso, S 2014, 'Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis', SCHIZOPHR RES, Jg. 159, Nr. 1, S. 56-61. https://doi.org/10.1016/j.schres.2014.07.013

APA

Theleritis, C., Fisher, H. L., Schäfer, I., Winters, L. E., Stahl, D., Morgan, C., Dazzan, P., Breedvelt, J., Sambath, I., Vitoratou, S., Russo, M., Reichenberg, A., Aurora Falcone, M., Mondelli, V., O'Connor, J., David, A., McGuire, P., Pariante, C., Di Forti, M., ... Bonaccorso, S. (2014). Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis. SCHIZOPHR RES, 159(1), 56-61. https://doi.org/10.1016/j.schres.2014.07.013

Vancouver

Theleritis C, Fisher HL, Schäfer I, Winters LE, Stahl D, Morgan C et al. Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis. SCHIZOPHR RES. 2014 Okt 1;159(1):56-61. https://doi.org/10.1016/j.schres.2014.07.013

Bibtex

@article{cd616d163e8e44c3b40965a43898c16e,
title = "Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis",
abstract = "BACKGROUND: The Brain-derived Neurotrophic Factor (BDNF) modulates cognitive processes and is associated with increased risk of schizophrenia. Childhood trauma (CT) is frequent in patients with psychosis and severely affects course and outcome.AIMS: We investigated the hypothesis that BDNF is associated with both CT and cognitive deficits in a sample of first-episode psychosis (FEP) cases and unaffected controls.METHOD: Participants with FEP and healthy controls were recruited between August 2008 and July 2011 from South London, UK. Childhood traumatic events were detected using the Childhood Experience of Care and Abuse Questionnaire (CECA-Q). Neuropsychological data were also collected. BDNF plasma levels were measured from fasting blood samples.RESULTS: Data were available on 87 FEP patients and 152 controls. Our results showed a significant effect of separation (F=5.5; df=1,115; p=.02), physical (F=4.7; df=1, 118; p=.03) and sexual abuse (F=5.4; df=1,117; p=.02) on BDNF levels with lower levels among those who experienced the traumatic event compared to those who did not. Physical abuse predicted lower plasma levels of BDNF (β=-.30; p=.03) whereas sexual and/or physical abuse showed a trend (β=-.26; p=.06) in FEP patients but not in unaffected controls. No association between BDNF plasma levels and cognitive functions was found among patients with FEP and controls.CONCLUSION: Our findings suggest the possible involvement of BDNF in the onset of first-episode psychosis in individuals exposed to early trauma and propose BDNF as a potential clinical biomarker to detect the detrimental effects of CT on human brain plasticity.",
author = "Christos Theleritis and Fisher, {Helen L} and Ingo Sch{\"a}fer and Winters, {Laura E} and Daniel Stahl and Craig Morgan and Paola Dazzan and Josefien Breedvelt and Irene Sambath and Silia Vitoratou and Manuela Russo and Abraham Reichenberg and {Aurora Falcone}, M and Valeria Mondelli and Jennifer O'Connor and Anthony David and Philip McGuire and Carmine Pariante and {Di Forti}, Marta and Murray, {Robin M} and Stefania Bonaccorso",
note = "Crown Copyright {\textcopyright} 2014. Published by Elsevier B.V. All rights reserved.",
year = "2014",
month = oct,
day = "1",
doi = "10.1016/j.schres.2014.07.013",
language = "English",
volume = "159",
pages = "56--61",
journal = "SCHIZOPHR RES",
issn = "0920-9964",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Brain derived Neurotropic Factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis

AU - Theleritis, Christos

AU - Fisher, Helen L

AU - Schäfer, Ingo

AU - Winters, Laura E

AU - Stahl, Daniel

AU - Morgan, Craig

AU - Dazzan, Paola

AU - Breedvelt, Josefien

AU - Sambath, Irene

AU - Vitoratou, Silia

AU - Russo, Manuela

AU - Reichenberg, Abraham

AU - Aurora Falcone, M

AU - Mondelli, Valeria

AU - O'Connor, Jennifer

AU - David, Anthony

AU - McGuire, Philip

AU - Pariante, Carmine

AU - Di Forti, Marta

AU - Murray, Robin M

AU - Bonaccorso, Stefania

N1 - Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BACKGROUND: The Brain-derived Neurotrophic Factor (BDNF) modulates cognitive processes and is associated with increased risk of schizophrenia. Childhood trauma (CT) is frequent in patients with psychosis and severely affects course and outcome.AIMS: We investigated the hypothesis that BDNF is associated with both CT and cognitive deficits in a sample of first-episode psychosis (FEP) cases and unaffected controls.METHOD: Participants with FEP and healthy controls were recruited between August 2008 and July 2011 from South London, UK. Childhood traumatic events were detected using the Childhood Experience of Care and Abuse Questionnaire (CECA-Q). Neuropsychological data were also collected. BDNF plasma levels were measured from fasting blood samples.RESULTS: Data were available on 87 FEP patients and 152 controls. Our results showed a significant effect of separation (F=5.5; df=1,115; p=.02), physical (F=4.7; df=1, 118; p=.03) and sexual abuse (F=5.4; df=1,117; p=.02) on BDNF levels with lower levels among those who experienced the traumatic event compared to those who did not. Physical abuse predicted lower plasma levels of BDNF (β=-.30; p=.03) whereas sexual and/or physical abuse showed a trend (β=-.26; p=.06) in FEP patients but not in unaffected controls. No association between BDNF plasma levels and cognitive functions was found among patients with FEP and controls.CONCLUSION: Our findings suggest the possible involvement of BDNF in the onset of first-episode psychosis in individuals exposed to early trauma and propose BDNF as a potential clinical biomarker to detect the detrimental effects of CT on human brain plasticity.

AB - BACKGROUND: The Brain-derived Neurotrophic Factor (BDNF) modulates cognitive processes and is associated with increased risk of schizophrenia. Childhood trauma (CT) is frequent in patients with psychosis and severely affects course and outcome.AIMS: We investigated the hypothesis that BDNF is associated with both CT and cognitive deficits in a sample of first-episode psychosis (FEP) cases and unaffected controls.METHOD: Participants with FEP and healthy controls were recruited between August 2008 and July 2011 from South London, UK. Childhood traumatic events were detected using the Childhood Experience of Care and Abuse Questionnaire (CECA-Q). Neuropsychological data were also collected. BDNF plasma levels were measured from fasting blood samples.RESULTS: Data were available on 87 FEP patients and 152 controls. Our results showed a significant effect of separation (F=5.5; df=1,115; p=.02), physical (F=4.7; df=1, 118; p=.03) and sexual abuse (F=5.4; df=1,117; p=.02) on BDNF levels with lower levels among those who experienced the traumatic event compared to those who did not. Physical abuse predicted lower plasma levels of BDNF (β=-.30; p=.03) whereas sexual and/or physical abuse showed a trend (β=-.26; p=.06) in FEP patients but not in unaffected controls. No association between BDNF plasma levels and cognitive functions was found among patients with FEP and controls.CONCLUSION: Our findings suggest the possible involvement of BDNF in the onset of first-episode psychosis in individuals exposed to early trauma and propose BDNF as a potential clinical biomarker to detect the detrimental effects of CT on human brain plasticity.

U2 - 10.1016/j.schres.2014.07.013

DO - 10.1016/j.schres.2014.07.013

M3 - SCORING: Journal article

C2 - 25171858

VL - 159

SP - 56

EP - 61

JO - SCHIZOPHR RES

JF - SCHIZOPHR RES

SN - 0920-9964

IS - 1

ER -