Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies.

TY - JOUR

T1 - Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies.

AU - Wingenfeld, Katja

AU - Spitzer, Carsten

AU - Rullkötter, Nina

AU - Löwe, Bernd

PY - 2010

Y1 - 2010

N2 - Borderline personality disorder (BPD) is a complex and serious mental disorder that is commonly seen psychiatric practice. Although stress, especially early life stress, seems to be associated with the development of the disorder, there has been far less research on the function of the hypothalamic-pituitary-adrenal (HPA) axis in BPD, compared to other psychiatric disorders, such as major depressive disorder and post-traumatic stress disorder. Stress has been suggested to exert damaging effects on the brain, particularly the hippocampus; therefore, neuroimaging studies yield important insight into the neurobiology of BPD. This article reviews research on the HPA axis and neuroimaging studies in BPD and aims to integrate these findings.

AB - Borderline personality disorder (BPD) is a complex and serious mental disorder that is commonly seen psychiatric practice. Although stress, especially early life stress, seems to be associated with the development of the disorder, there has been far less research on the function of the hypothalamic-pituitary-adrenal (HPA) axis in BPD, compared to other psychiatric disorders, such as major depressive disorder and post-traumatic stress disorder. Stress has been suggested to exert damaging effects on the brain, particularly the hippocampus; therefore, neuroimaging studies yield important insight into the neurobiology of BPD. This article reviews research on the HPA axis and neuroimaging studies in BPD and aims to integrate these findings.

M3 - SCORING: Zeitschriftenaufsatz

VL - 35

SP - 154

EP - 170

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

IS - 1

M1 - 1

ER -