Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
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Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology. / Gómez-Barrena, Enrique; Rosset, Philippe; Müller, Ingo; Giordano, Rosaria; Bunu, Carmen; Layrolle, Pierre; Konttinen, Yrjö T; Luyten, Frank P.
in: J CELL MOL MED, Jahrgang 15, Nr. 6, 6, 2011, S. 1266-1286.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
AU - Gómez-Barrena, Enrique
AU - Rosset, Philippe
AU - Müller, Ingo
AU - Giordano, Rosaria
AU - Bunu, Carmen
AU - Layrolle, Pierre
AU - Konttinen, Yrjö T
AU - Luyten, Frank P
PY - 2011
Y1 - 2011
N2 - Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue. Cell based therapies are promising new therapeutic approaches in regenerative medicine. By using mesenchymal stem cells, good results have been reported for bone engineering in a number of clinical studies, most of them investigator initiated trials with limited scope with respect to controls and outcome. With the implementation of a new regulatory framework for advanced therapeutic medicinal products, the stage is set to improve both the characterization of the cells and combination products, and pave the way for improved controlled and well-designed clinical trials. The incorporation of more personalized medicine approaches, including the use of biomarkers to identify the proper patients and the responders to treatment, will be contributing to progress in the field. Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering.
AB - Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue. Cell based therapies are promising new therapeutic approaches in regenerative medicine. By using mesenchymal stem cells, good results have been reported for bone engineering in a number of clinical studies, most of them investigator initiated trials with limited scope with respect to controls and outcome. With the implementation of a new regulatory framework for advanced therapeutic medicinal products, the stage is set to improve both the characterization of the cells and combination products, and pave the way for improved controlled and well-designed clinical trials. The incorporation of more personalized medicine approaches, including the use of biomarkers to identify the proper patients and the responders to treatment, will be contributing to progress in the field. Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering.
KW - Adult
KW - Humans
KW - Research Design
KW - Clinical Trials as Topic
KW - Child, Preschool
KW - Biomedical Research
KW - Bone Regeneration
KW - Bone and Bones/abnormalities/pathology
KW - Mesenchymal Stem Cell Transplantation/ethics/methods
KW - Mesenchymal Stem Cells
KW - Orthopedics/ethics/methods
KW - Regenerative Medicine/ethics/methods
KW - Tissue Engineering/ethics/methods
KW - Traumatology/ethics/methods
KW - Adult
KW - Humans
KW - Research Design
KW - Clinical Trials as Topic
KW - Child, Preschool
KW - Biomedical Research
KW - Bone Regeneration
KW - Bone and Bones/abnormalities/pathology
KW - Mesenchymal Stem Cell Transplantation/ethics/methods
KW - Mesenchymal Stem Cells
KW - Orthopedics/ethics/methods
KW - Regenerative Medicine/ethics/methods
KW - Tissue Engineering/ethics/methods
KW - Traumatology/ethics/methods
U2 - 10.1111/j.1582-4934.2011.01265.x
DO - 10.1111/j.1582-4934.2011.01265.x
M3 - SCORING: Journal article
VL - 15
SP - 1266
EP - 1286
JO - J CELL MOL MED
JF - J CELL MOL MED
SN - 1582-1838
IS - 6
M1 - 6
ER -
