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Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

Standard

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels. / Jammal Salameh, Luna; Bitzenhofer, Sebastian H; Hanganu-Opatz, Ileana L; Dutschmann, Mathias; Egger, Veronica.

in: SCIENCE, Jahrgang 383, Nr. 6682, 02.02.2024, S. eadk8511.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jammal Salameh, L, Bitzenhofer, SH, Hanganu-Opatz, IL, Dutschmann, M & Egger, V 2024, 'Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels', SCIENCE, Jg. 383, Nr. 6682, S. eadk8511. https://doi.org/10.1126/science.adk8511

APA

Jammal Salameh, L., Bitzenhofer, S. H., Hanganu-Opatz, I. L., Dutschmann, M., & Egger, V. (2024). Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels. SCIENCE, 383(6682), eadk8511. https://doi.org/10.1126/science.adk8511

Vancouver

Jammal Salameh L, Bitzenhofer SH, Hanganu-Opatz IL, Dutschmann M, Egger V. Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels. SCIENCE. 2024 Feb 2;383(6682):eadk8511. https://doi.org/10.1126/science.adk8511

Bibtex

@article{5e44c364c2eb42b78901ea16d0675257,
title = "Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels",
abstract = "The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within ~20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.",
keywords = "Rats, Animals, Blood Pressure, Neurons/physiology, Synaptic Transmission, Olfactory Bulb/physiology, Ion Channels",
author = "{Jammal Salameh}, Luna and Bitzenhofer, {Sebastian H} and Hanganu-Opatz, {Ileana L} and Mathias Dutschmann and Veronica Egger",
year = "2024",
month = feb,
day = "2",
doi = "10.1126/science.adk8511",
language = "English",
volume = "383",
pages = "eadk8511",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6682",

}

RIS

TY - JOUR

T1 - Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

AU - Jammal Salameh, Luna

AU - Bitzenhofer, Sebastian H

AU - Hanganu-Opatz, Ileana L

AU - Dutschmann, Mathias

AU - Egger, Veronica

PY - 2024/2/2

Y1 - 2024/2/2

N2 - The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within ~20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.

AB - The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within ~20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.

KW - Rats

KW - Animals

KW - Blood Pressure

KW - Neurons/physiology

KW - Synaptic Transmission

KW - Olfactory Bulb/physiology

KW - Ion Channels

U2 - 10.1126/science.adk8511

DO - 10.1126/science.adk8511

M3 - SCORING: Journal article

C2 - 38301001

VL - 383

SP - eadk8511

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6682

ER -