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Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs)

Standard

Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs). / Nentwich, M F; Menzel, K; Reeh, M; Uzunoglu, F G; Ghadban, T; Bachmann, K; Schrader, J; Bockhorn, M; Izbicki, J R; Perez, D.

in: EJSO-EUR J SURG ONC, Jahrgang 43, Nr. 4, 04.2017, S. 758-762.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nentwich, MF, Menzel, K, Reeh, M, Uzunoglu, FG, Ghadban, T, Bachmann, K, Schrader, J, Bockhorn, M, Izbicki, JR & Perez, D 2017, 'Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs)', EJSO-EUR J SURG ONC, Jg. 43, Nr. 4, S. 758-762. https://doi.org/10.1016/j.ejso.2016.12.013

APA

Nentwich, M. F., Menzel, K., Reeh, M., Uzunoglu, F. G., Ghadban, T., Bachmann, K., Schrader, J., Bockhorn, M., Izbicki, J. R., & Perez, D. (2017). Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs). EJSO-EUR J SURG ONC, 43(4), 758-762. https://doi.org/10.1016/j.ejso.2016.12.013

Vancouver

Nentwich MF, Menzel K, Reeh M, Uzunoglu FG, Ghadban T, Bachmann K et al. Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs). EJSO-EUR J SURG ONC. 2017 Apr;43(4):758-762. https://doi.org/10.1016/j.ejso.2016.12.013

Bibtex

@article{656fe094358e4311903a0418318a2a2a,
title = "Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs)",
abstract = "BACKROUND: The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients to surgical resection or watchful waiting is still under debate. Additional markers to better separate low and high-risk lesions would improve patient selection.METHODS: Patients who underwent pancreatic resections for IPMNs between January 2008 and December 2012 with available blood samples were selected and retrospectively assessed. Data on cyst characteristics such as cyst size, duct relation and main-duct dilatation were collected and plasma fibrinogen levels were measured.RESULTS: A total of 73 patients fulfilled the inclusion criteria by pancreatic resection for pathologically confirmed IPMN and available blood sample. Histologically, IPMNs were classified as low-grade and borderline in 52 (71.2%, group 1) and as high-grade and invasive in 21 (28.8%, group 2) of all cases. Fibrinogen levels showed significant differences between the two groups (group 1: mean 3.62 g/L (SD ± 1.14); group 2: mean 4.49 g/L (SD ± 1.57); p = 0.027). A ROC-curve analysis calculated cut-off value of 4.71 g/L separated groups 1 and 2 (p = 0.008). Fibrinogen levels remained as the only significant factor in multivariable analysis, cyst size and duct relation were not significant.CONCLUSION: Blood fibrinogen differed between low and high risk IPMNs and therefore, the use of fibrinogen as an additional discriminator in the pre-operative risk assessment of IPMNs should be further evaluated.",
author = "Nentwich, {M F} and K Menzel and M Reeh and Uzunoglu, {F G} and T Ghadban and K Bachmann and J Schrader and M Bockhorn and Izbicki, {J R} and D Perez",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.",
year = "2017",
month = apr,
doi = "10.1016/j.ejso.2016.12.013",
language = "English",
volume = "43",
pages = "758--762",
journal = "EJSO-EUR J SURG ONC",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs)

AU - Nentwich, M F

AU - Menzel, K

AU - Reeh, M

AU - Uzunoglu, F G

AU - Ghadban, T

AU - Bachmann, K

AU - Schrader, J

AU - Bockhorn, M

AU - Izbicki, J R

AU - Perez, D

N1 - Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

PY - 2017/4

Y1 - 2017/4

N2 - BACKROUND: The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients to surgical resection or watchful waiting is still under debate. Additional markers to better separate low and high-risk lesions would improve patient selection.METHODS: Patients who underwent pancreatic resections for IPMNs between January 2008 and December 2012 with available blood samples were selected and retrospectively assessed. Data on cyst characteristics such as cyst size, duct relation and main-duct dilatation were collected and plasma fibrinogen levels were measured.RESULTS: A total of 73 patients fulfilled the inclusion criteria by pancreatic resection for pathologically confirmed IPMN and available blood sample. Histologically, IPMNs were classified as low-grade and borderline in 52 (71.2%, group 1) and as high-grade and invasive in 21 (28.8%, group 2) of all cases. Fibrinogen levels showed significant differences between the two groups (group 1: mean 3.62 g/L (SD ± 1.14); group 2: mean 4.49 g/L (SD ± 1.57); p = 0.027). A ROC-curve analysis calculated cut-off value of 4.71 g/L separated groups 1 and 2 (p = 0.008). Fibrinogen levels remained as the only significant factor in multivariable analysis, cyst size and duct relation were not significant.CONCLUSION: Blood fibrinogen differed between low and high risk IPMNs and therefore, the use of fibrinogen as an additional discriminator in the pre-operative risk assessment of IPMNs should be further evaluated.

AB - BACKROUND: The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients to surgical resection or watchful waiting is still under debate. Additional markers to better separate low and high-risk lesions would improve patient selection.METHODS: Patients who underwent pancreatic resections for IPMNs between January 2008 and December 2012 with available blood samples were selected and retrospectively assessed. Data on cyst characteristics such as cyst size, duct relation and main-duct dilatation were collected and plasma fibrinogen levels were measured.RESULTS: A total of 73 patients fulfilled the inclusion criteria by pancreatic resection for pathologically confirmed IPMN and available blood sample. Histologically, IPMNs were classified as low-grade and borderline in 52 (71.2%, group 1) and as high-grade and invasive in 21 (28.8%, group 2) of all cases. Fibrinogen levels showed significant differences between the two groups (group 1: mean 3.62 g/L (SD ± 1.14); group 2: mean 4.49 g/L (SD ± 1.57); p = 0.027). A ROC-curve analysis calculated cut-off value of 4.71 g/L separated groups 1 and 2 (p = 0.008). Fibrinogen levels remained as the only significant factor in multivariable analysis, cyst size and duct relation were not significant.CONCLUSION: Blood fibrinogen differed between low and high risk IPMNs and therefore, the use of fibrinogen as an additional discriminator in the pre-operative risk assessment of IPMNs should be further evaluated.

U2 - 10.1016/j.ejso.2016.12.013

DO - 10.1016/j.ejso.2016.12.013

M3 - SCORING: Journal article

C2 - 28131667

VL - 43

SP - 758

EP - 762

JO - EJSO-EUR J SURG ONC

JF - EJSO-EUR J SURG ONC

SN - 0748-7983

IS - 4

ER -