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Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy

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Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy. / Kuo, Hsiao-Hsuan; Banga, Riddhima; Lee, Guinevere Q; Gao, Ce; Cavassini, Matthias; Corpataux, Jean-Marc; Blackmer, Jane E; Zur Wiesch, Schulze; Yu, Xu G; Pantaleo, Giuseppe; Perreau, Matthieu; Lichterfeld, Mathias.

in: J INFECT DIS, Jahrgang 222, Nr. 4, 23.07.2020, S. 655-660.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kuo, H-H, Banga, R, Lee, GQ, Gao, C, Cavassini, M, Corpataux, J-M, Blackmer, JE, Zur Wiesch, S, Yu, XG, Pantaleo, G, Perreau, M & Lichterfeld, M 2020, 'Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy', J INFECT DIS, Jg. 222, Nr. 4, S. 655-660. https://doi.org/10.1093/infdis/jiaa137

APA

Kuo, H-H., Banga, R., Lee, G. Q., Gao, C., Cavassini, M., Corpataux, J-M., Blackmer, J. E., Zur Wiesch, S., Yu, X. G., Pantaleo, G., Perreau, M., & Lichterfeld, M. (2020). Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy. J INFECT DIS, 222(4), 655-660. https://doi.org/10.1093/infdis/jiaa137

Vancouver

Kuo H-H, Banga R, Lee GQ, Gao C, Cavassini M, Corpataux J-M et al. Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy. J INFECT DIS. 2020 Jul 23;222(4):655-660. https://doi.org/10.1093/infdis/jiaa137

Bibtex

@article{0a7a11274a904d5aa76ed16be60ff8cc,
title = "Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy",
abstract = "The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, we noted multiple clonal clusters of identical intact or defective proviral sequences from distinct compartments and CD4 T-cell subpopulations, suggesting frequent interchanges between viral reservoir cells in blood and tissues.",
author = "Hsiao-Hsuan Kuo and Riddhima Banga and Lee, {Guinevere Q} and Ce Gao and Matthias Cavassini and Jean-Marc Corpataux and Blackmer, {Jane E} and {Zur Wiesch}, Schulze and Yu, {Xu G} and Giuseppe Pantaleo and Matthieu Perreau and Mathias Lichterfeld",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = jul,
day = "23",
doi = "10.1093/infdis/jiaa137",
language = "English",
volume = "222",
pages = "655--660",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy

AU - Kuo, Hsiao-Hsuan

AU - Banga, Riddhima

AU - Lee, Guinevere Q

AU - Gao, Ce

AU - Cavassini, Matthias

AU - Corpataux, Jean-Marc

AU - Blackmer, Jane E

AU - Zur Wiesch, Schulze

AU - Yu, Xu G

AU - Pantaleo, Giuseppe

AU - Perreau, Matthieu

AU - Lichterfeld, Mathias

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/7/23

Y1 - 2020/7/23

N2 - The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, we noted multiple clonal clusters of identical intact or defective proviral sequences from distinct compartments and CD4 T-cell subpopulations, suggesting frequent interchanges between viral reservoir cells in blood and tissues.

AB - The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, we noted multiple clonal clusters of identical intact or defective proviral sequences from distinct compartments and CD4 T-cell subpopulations, suggesting frequent interchanges between viral reservoir cells in blood and tissues.

U2 - 10.1093/infdis/jiaa137

DO - 10.1093/infdis/jiaa137

M3 - SCORING: Journal article

C2 - 32236405

VL - 222

SP - 655

EP - 660

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 4

ER -