PortalPublikationenBivalvular transcatheter treatment of high-surgical-risk pat...

Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation

Standard

Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation. / Rudolph, Volker; Schirmer, Johannes; Franzen, Olaf; Schlüter, Michael; Seiffert, Moritz; Treede, Hendrik; Reichenspurner, Hermann; Blankenberg, Stefan; Baldus, Stephan.

in: INT J CARDIOL, Jahrgang 167, Nr. 3, 10.08.2013, S. 716-720.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rudolph, V, Schirmer, J, Franzen, O, Schlüter, M, Seiffert, M, Treede, H, Reichenspurner, H, Blankenberg, S & Baldus, S 2013, 'Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation', INT J CARDIOL, Jg. 167, Nr. 3, S. 716-720. https://doi.org/10.1016/j.ijcard.2012.03.060

APA

Rudolph, V., Schirmer, J., Franzen, O., Schlüter, M., Seiffert, M., Treede, H., Reichenspurner, H., Blankenberg, S., & Baldus, S. (2013). Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation. INT J CARDIOL, 167(3), 716-720. https://doi.org/10.1016/j.ijcard.2012.03.060

Vancouver

Rudolph V, Schirmer J, Franzen O, Schlüter M, Seiffert M, Treede H et al. Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation. INT J CARDIOL. 2013 Aug 10;167(3):716-720. https://doi.org/10.1016/j.ijcard.2012.03.060

Bibtex

@article{cfa8bbbc5842465295c31e0d0d208c61,
title = "Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation",
abstract = "BACKGROUND: In inoperable or high-surgical-risk patients, transcatheter aortic valve replacement (TAVR) and repair of the mitral valve using the MitraClip have emerged as novel treatment strategies. We sought to assess the feasibility and effectiveness of bivalvular transcatheter therapy in patients with coexisting aortic stenosis and mitral regurgitation.METHODS: Out of 285 patients treated with TAVR and 226 patients who underwent MitraClip therapy at our institution, 11 patients (78 ± 6years, 9 men [82%]) received both therapies. TAVR preceded MitraClip therapy in 10 patients, with 3 patients undergoing both interventions in a single session.RESULTS: TAVR via transapical (n = 6) or transfemoral (n = 5) access utilized the Sapien/Sapien XT and CoreValve prostheses in 7 and 4 patients, respectively. All TAVR procedures were successful, with significant increases in effective aortic orifice area and decreases in mean transvalvular pressure gradient. MitraClip therapy succeeded in reducing MR severity to <2+ in 10 patients. Periprocedurally, 1 patient sustained a stroke. At a median of 208 days, 2 patients were in NYHA functional class II, with only 1 patient improved from before TAVR, and 6 patients were in class III (improvement in 1). Four patients had died at a median of 60 days after MitraClip therapy.CONCLUSION: Bivalvular transcatheter treatment of patients with coexisting aortic stenosis and MR is technically feasible, even in a single session. Given the low prevalence of midterm functional improvement, factors predictive of clinical benefit from catheter-based double-valve intervention remain to be determined.",
keywords = "Aged, Aged, 80 and over, Aortic Valve Stenosis/diagnosis, Cardiac Catheterization/methods, Feasibility Studies, Female, Heart Valve Prosthesis Implantation/methods, Humans, Male, Mitral Valve Insufficiency/diagnosis, Risk Factors, Severity of Illness Index, Surgical Instruments, Treatment Outcome",
author = "Volker Rudolph and Johannes Schirmer and Olaf Franzen and Michael Schl{\"u}ter and Moritz Seiffert and Hendrik Treede and Hermann Reichenspurner and Stefan Blankenberg and Stephan Baldus",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = aug,
day = "10",
doi = "10.1016/j.ijcard.2012.03.060",
language = "English",
volume = "167",
pages = "716--720",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation

AU - Rudolph, Volker

AU - Schirmer, Johannes

AU - Franzen, Olaf

AU - Schlüter, Michael

AU - Seiffert, Moritz

AU - Treede, Hendrik

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Baldus, Stephan

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/8/10

Y1 - 2013/8/10

N2 - BACKGROUND: In inoperable or high-surgical-risk patients, transcatheter aortic valve replacement (TAVR) and repair of the mitral valve using the MitraClip have emerged as novel treatment strategies. We sought to assess the feasibility and effectiveness of bivalvular transcatheter therapy in patients with coexisting aortic stenosis and mitral regurgitation.METHODS: Out of 285 patients treated with TAVR and 226 patients who underwent MitraClip therapy at our institution, 11 patients (78 ± 6years, 9 men [82%]) received both therapies. TAVR preceded MitraClip therapy in 10 patients, with 3 patients undergoing both interventions in a single session.RESULTS: TAVR via transapical (n = 6) or transfemoral (n = 5) access utilized the Sapien/Sapien XT and CoreValve prostheses in 7 and 4 patients, respectively. All TAVR procedures were successful, with significant increases in effective aortic orifice area and decreases in mean transvalvular pressure gradient. MitraClip therapy succeeded in reducing MR severity to <2+ in 10 patients. Periprocedurally, 1 patient sustained a stroke. At a median of 208 days, 2 patients were in NYHA functional class II, with only 1 patient improved from before TAVR, and 6 patients were in class III (improvement in 1). Four patients had died at a median of 60 days after MitraClip therapy.CONCLUSION: Bivalvular transcatheter treatment of patients with coexisting aortic stenosis and MR is technically feasible, even in a single session. Given the low prevalence of midterm functional improvement, factors predictive of clinical benefit from catheter-based double-valve intervention remain to be determined.

AB - BACKGROUND: In inoperable or high-surgical-risk patients, transcatheter aortic valve replacement (TAVR) and repair of the mitral valve using the MitraClip have emerged as novel treatment strategies. We sought to assess the feasibility and effectiveness of bivalvular transcatheter therapy in patients with coexisting aortic stenosis and mitral regurgitation.METHODS: Out of 285 patients treated with TAVR and 226 patients who underwent MitraClip therapy at our institution, 11 patients (78 ± 6years, 9 men [82%]) received both therapies. TAVR preceded MitraClip therapy in 10 patients, with 3 patients undergoing both interventions in a single session.RESULTS: TAVR via transapical (n = 6) or transfemoral (n = 5) access utilized the Sapien/Sapien XT and CoreValve prostheses in 7 and 4 patients, respectively. All TAVR procedures were successful, with significant increases in effective aortic orifice area and decreases in mean transvalvular pressure gradient. MitraClip therapy succeeded in reducing MR severity to <2+ in 10 patients. Periprocedurally, 1 patient sustained a stroke. At a median of 208 days, 2 patients were in NYHA functional class II, with only 1 patient improved from before TAVR, and 6 patients were in class III (improvement in 1). Four patients had died at a median of 60 days after MitraClip therapy.CONCLUSION: Bivalvular transcatheter treatment of patients with coexisting aortic stenosis and MR is technically feasible, even in a single session. Given the low prevalence of midterm functional improvement, factors predictive of clinical benefit from catheter-based double-valve intervention remain to be determined.

KW - Aged

KW - Aged, 80 and over

KW - Aortic Valve Stenosis/diagnosis

KW - Cardiac Catheterization/methods

KW - Feasibility Studies

KW - Female

KW - Heart Valve Prosthesis Implantation/methods

KW - Humans

KW - Male

KW - Mitral Valve Insufficiency/diagnosis

KW - Risk Factors

KW - Severity of Illness Index

KW - Surgical Instruments

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2012.03.060

DO - 10.1016/j.ijcard.2012.03.060

M3 - SCORING: Journal article

C2 - 22459381

VL - 167

SP - 716

EP - 720

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 3

ER -