Biologically and chemically optimized composites of carbonated apatite and polyglycolide as bone substitution materials.

  • W Linhart
  • F Peters
  • W Lehmann
  • K Schwarz
  • Arndt Schilling
  • M Amling
  • J M Rueger
  • M Epple

Abstract

We report on the development and characterization of a new composite material consisting of amorphous carbonated apatite, Ca(5)(PO(4), CO(3))(3)(OH), and microstructured poly(hydroxyacetic acid), polyglycolide (PGA). This material is able to keep the pH of a surrounding solution within the physiological range (7.2-7.6). This was achieved by chemical fine-tuning of the counterplay between the acidic degradation of the polyester and the basic dissolution of calcium phosphate. Microporous samples with pore sizes of

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer2
ISSN0021-9304
StatusVeröffentlicht - 2001
pubmed 11093175