Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
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Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus. / Smetanina, Olga F; Yurchenko, Anton N; Girich Ivanets, Elena V; Trinh, Phan Thi Hoai; Antonov, Alexander S; Dyshlovoy, Sergey A; von Amsberg, Gunhild; Kim, Natalya Y; Chingizova, Ekaterina A; Pislyagin, Evgeny A; Menchinskaya, Ekaterina S; Yurchenko, Ekaterina A; Van, Tran Thi Thanh; Afiyatullov, Shamil S.
in: MOLECULES, Jahrgang 25, Nr. 1, 23.12.2019.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
AU - Smetanina, Olga F
AU - Yurchenko, Anton N
AU - Girich Ivanets, Elena V
AU - Trinh, Phan Thi Hoai
AU - Antonov, Alexander S
AU - Dyshlovoy, Sergey A
AU - von Amsberg, Gunhild
AU - Kim, Natalya Y
AU - Chingizova, Ekaterina A
AU - Pislyagin, Evgeny A
AU - Menchinskaya, Ekaterina S
AU - Yurchenko, Ekaterina A
AU - Van, Tran Thi Thanh
AU - Afiyatullov, Shamil S
PY - 2019/12/23
Y1 - 2019/12/23
N2 - Seven known echinulin-related indolediketopiperazine alkaloids (1-7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
AB - Seven known echinulin-related indolediketopiperazine alkaloids (1-7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
U2 - 10.3390/molecules25010061
DO - 10.3390/molecules25010061
M3 - SCORING: Journal article
C2 - 31878044
VL - 25
JO - MOLECULES
JF - MOLECULES
SN - 1420-3049
IS - 1
ER -