Biokompatibilität von Farbstoffen für die vitreoretinale Chirurgie
Standard
Biokompatibilität von Farbstoffen für die vitreoretinale Chirurgie. / Thaler, S; Schüttauf, F; Haritoglou, C.
in: OPHTHALMOLOGE, Jahrgang 106, Nr. 1, 01.2009, S. 11-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Biokompatibilität von Farbstoffen für die vitreoretinale Chirurgie
AU - Thaler, S
AU - Schüttauf, F
AU - Haritoglou, C
PY - 2009/1
Y1 - 2009/1
N2 - For the last 8 years vital dyes have been used to visualize preretinal semitransparent structures in the eye during vitroretinal surgery. However, indocyanine green (ICG), which was the first commonly used dye, proved to be partly toxic to retinal cells and the retinal pigment epithelium in various in vitro and in vivo studies. Therefore, an intensive search for new and safer dyes was started. At present three dyes, trypan blue, patent blue and brilliant blue are predominantly used for vitreoretinal surgery, in addition to ICG. In this article an overview of preclinical biocompatibility studies for common vital dyes is presented. Additionally, a systematic approach for testing of new candidate dyes for vitreoretinal surgery will be proposed.
AB - For the last 8 years vital dyes have been used to visualize preretinal semitransparent structures in the eye during vitroretinal surgery. However, indocyanine green (ICG), which was the first commonly used dye, proved to be partly toxic to retinal cells and the retinal pigment epithelium in various in vitro and in vivo studies. Therefore, an intensive search for new and safer dyes was started. At present three dyes, trypan blue, patent blue and brilliant blue are predominantly used for vitreoretinal surgery, in addition to ICG. In this article an overview of preclinical biocompatibility studies for common vital dyes is presented. Additionally, a systematic approach for testing of new candidate dyes for vitreoretinal surgery will be proposed.
KW - Biocompatible Materials
KW - Coloring Agents
KW - Humans
KW - Image Enhancement/methods
KW - Ophthalmologic Surgical Procedures/methods
KW - Surgery, Computer-Assisted/methods
KW - Vitreoretinopathy, Proliferative/pathology
U2 - 10.1007/s00347-008-1854-4
DO - 10.1007/s00347-008-1854-4
M3 - SCORING: Review
C2 - 19139900
VL - 106
SP - 11
EP - 15
JO - OPHTHALMOLOGE
JF - OPHTHALMOLOGE
SN - 0941-293X
IS - 1
ER -
