Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy

Zeena Gadsby; Jack Garland; Melissa Thompson; Benjamin Ondruschka; Ugo Da Broi; Rexson Tse

doi:10.1097/PAF.0000000000000869

Binucleated Myocytes and Heart Weight

Standard

Binucleated Myocytes and Heart Weight : A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy. / Gadsby, Zeena; Garland, Jack; Thompson, Melissa; Ondruschka, Benjamin; Da Broi, Ugo; Tse, Rexson.

in: AM J FOREN MED PATH, Jahrgang 44, Nr. 4, 01.12.2023, S. 273-277.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gadsby, Z, Garland, J, Thompson, M, Ondruschka, B, Da Broi, U & Tse, R 2023, 'Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy', AM J FOREN MED PATH, Jg. 44, Nr. 4, S. 273-277. https://doi.org/10.1097/PAF.0000000000000869

APA

Gadsby, Z., Garland, J., Thompson, M., Ondruschka, B., Da Broi, U., & Tse, R. (2023). Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy. AM J FOREN MED PATH, 44(4), 273-277. https://doi.org/10.1097/PAF.0000000000000869

Vancouver

Gadsby Z, Garland J, Thompson M, Ondruschka B, Da Broi U, Tse R. Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy. AM J FOREN MED PATH. 2023 Dez 1;44(4):273-277. https://doi.org/10.1097/PAF.0000000000000869

Bibtex

@article{57a0f32c128e42e49d9de9038438b7c1,

title = "Binucleated Myocytes and Heart Weight: A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy",

abstract = "Hypertrophy of the heart is assessed by heart weight (and dimensions) and myocyte hypertrophy. Establishing an association between the two may be useful in assessing hypertrophy in cases where there are limitations in assessing the heart weight. This preliminary study explored the association between the number of binucleated myocytes (a feature of myocyte hypertrophy) in a randomly chosen single high-power field of the left ventricular free wall and heart weight in an adult White population. It also compared the number of binucleated myocytes between cases with increased heart weight (>400 g in female and >500 g in male) and cases with normal heart weight. Heart weight and number of binucleated myocytes correlated significantly in male only. Increased heart weight had a significantly higher number of binucleated myocytes, with 8.5 binucleated myocytes being able to segregate cases with increased heart weight (74% sensitivity and 79% specificity). The results of this study showed the number of binucleated myocytes may have a complementary role in assessing hypertrophy of the heart.",

author = "Zeena Gadsby and Jack Garland and Melissa Thompson and Benjamin Ondruschka and {Da Broi}, Ugo and Rexson Tse",

year = "2023",

month = dec,

day = "1",

doi = "10.1097/PAF.0000000000000869",

language = "English",

volume = "44",

pages = "273--277",

journal = "AM J FOREN MED PATH",

issn = "0195-7910",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

RIS

TY - JOUR

T1 - Binucleated Myocytes and Heart Weight

T2 - A Preliminary Study Linking Cardiac Hypertrophy and Myocyte Hypertrophy

AU - Gadsby, Zeena

AU - Garland, Jack

AU - Thompson, Melissa

AU - Ondruschka, Benjamin

AU - Da Broi, Ugo

AU - Tse, Rexson

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Hypertrophy of the heart is assessed by heart weight (and dimensions) and myocyte hypertrophy. Establishing an association between the two may be useful in assessing hypertrophy in cases where there are limitations in assessing the heart weight. This preliminary study explored the association between the number of binucleated myocytes (a feature of myocyte hypertrophy) in a randomly chosen single high-power field of the left ventricular free wall and heart weight in an adult White population. It also compared the number of binucleated myocytes between cases with increased heart weight (>400 g in female and >500 g in male) and cases with normal heart weight. Heart weight and number of binucleated myocytes correlated significantly in male only. Increased heart weight had a significantly higher number of binucleated myocytes, with 8.5 binucleated myocytes being able to segregate cases with increased heart weight (74% sensitivity and 79% specificity). The results of this study showed the number of binucleated myocytes may have a complementary role in assessing hypertrophy of the heart.

AB - Hypertrophy of the heart is assessed by heart weight (and dimensions) and myocyte hypertrophy. Establishing an association between the two may be useful in assessing hypertrophy in cases where there are limitations in assessing the heart weight. This preliminary study explored the association between the number of binucleated myocytes (a feature of myocyte hypertrophy) in a randomly chosen single high-power field of the left ventricular free wall and heart weight in an adult White population. It also compared the number of binucleated myocytes between cases with increased heart weight (>400 g in female and >500 g in male) and cases with normal heart weight. Heart weight and number of binucleated myocytes correlated significantly in male only. Increased heart weight had a significantly higher number of binucleated myocytes, with 8.5 binucleated myocytes being able to segregate cases with increased heart weight (74% sensitivity and 79% specificity). The results of this study showed the number of binucleated myocytes may have a complementary role in assessing hypertrophy of the heart.

U2 - 10.1097/PAF.0000000000000869

DO - 10.1097/PAF.0000000000000869

M3 - SCORING: Journal article

C2 - 37527350

VL - 44

SP - 273

EP - 277

JO - AM J FOREN MED PATH

JF - AM J FOREN MED PATH

SN - 0195-7910

IS - 4

ER -