Binding of mistletoe lectins to cutaneous malignant melanoma: implications for prognosis and therapy.
Standard
Binding of mistletoe lectins to cutaneous malignant melanoma: implications for prognosis and therapy. / Dahl, Anka; Pfüller, U; Schachner, M; Horny, H P; Molls, I; Schumacher, U.
in: ANTICANCER RES, Jahrgang 21, Nr. 4, 4, 2001, S. 2883-2887.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Binding of mistletoe lectins to cutaneous malignant melanoma: implications for prognosis and therapy.
AU - Dahl, Anka
AU - Pfüller, U
AU - Schachner, M
AU - Horny, H P
AU - Molls, I
AU - Schumacher, U
PY - 2001
Y1 - 2001
N2 - BACKGROUND: Glycoconjugates, as detected by lectin histochemistry, have been implicated in metastasis formation in many neoplasias. However, no data concerning the three mistletoe lectins (MLs) and the spread of malignant melanoma have been published. MATERIALS AND METHODS: The binding status of ML-I, -II and -III was histochemically assessed in 100 malignant melanomas and correlated with metastasis in a 10 year follow-up period. Furthermore, the staining intensity of the three MLs, scored from negative (-) to very intense (+ + +), was evaluated. RESULTS: Kaplan-Meier analsis revealed that very intense binding (+ + +) of ML-I was positively-correlated with metastasis (p=0.044). CONCLUSION: Since ML-I is specific for galactose, high density galactose expression in malignant melanoma is a predictor of poor prognosis.
AB - BACKGROUND: Glycoconjugates, as detected by lectin histochemistry, have been implicated in metastasis formation in many neoplasias. However, no data concerning the three mistletoe lectins (MLs) and the spread of malignant melanoma have been published. MATERIALS AND METHODS: The binding status of ML-I, -II and -III was histochemically assessed in 100 malignant melanomas and correlated with metastasis in a 10 year follow-up period. Furthermore, the staining intensity of the three MLs, scored from negative (-) to very intense (+ + +), was evaluated. RESULTS: Kaplan-Meier analsis revealed that very intense binding (+ + +) of ML-I was positively-correlated with metastasis (p=0.044). CONCLUSION: Since ML-I is specific for galactose, high density galactose expression in malignant melanoma is a predictor of poor prognosis.
M3 - SCORING: Zeitschriftenaufsatz
VL - 21
SP - 2883
EP - 2887
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 4
M1 - 4
ER -
